Banco de dados de experimentos para fins de simulação em desenvolvimento de culturas agrícolas.

O artigo descreve a importância de um banco de dados para experimentos agrícolas na Embrapa e no SNPA (Sistema Nacional de Pesquisa Agropecuária) para fins de simulação em crescimento de culturas baseado na estrutura do DSSAT que foi apresentado em palestra nesse Workshop. Aborda-se o assunto na forma de um estudo de caso, onde empregou-se a técnica orientada a objetos (OMT de James Rum baugh) na análise do problema pra facilitar a captura de requisitos junto aos pesquisadores (futuros usuários do sistema). Exemplifica-se o uso da técnica OMT, mostrando-se a sua coerência entre modelos, adequação ao estudo de controle de experimentos e as dificuldades entradas no trabalho

Evolving missions and university entrepreneurship:Academic spin-offs and graduate start-ups in the entrepreneurial society

A recent call has urged to broaden the conceptualization of university entrepreneurship in order to appreciate the heterogeneity of contexts and actors involved in the process of entrepreneurial creation. A gap still persists in the understanding of the variety of ventures generated by different academic stakeholders, and the relationships between these entrepreneurial developments and university missions, namely, teaching and research. This paper addresses this particular gap by looking at how university teaching and research activities influence universities’ entrepreneurial ventures such as academic spin-offs and graduate start-ups. Empirically, we analyse the English higher education sector, drawing on institutional data at the university level. First, we explore the ways in which teaching and research activities are configured, and secondly, we examine how such configurations relate to academic spin-offs and graduate start-ups across different universities over time. Our findings suggest, first, that the evolution of USOs and graduate start-ups exhibit two different pathways over time; and second, that teaching and research both affect entrepreneurial ventures but their effect is different.JRC.B.4-Human Capital and Employmen

Chemopreventive Effects of (−)-Hinokinin against 1,2-Dimethylhydrazine-Induced Genotoxicity and Preneoplastic Lesions in Rat Colon

(−)-Hinokinin (<b>1</b>) is a dibenzylbutyrolactone lignan obtained by the partial synthesis of (−)-cubebin. This study reports the antigenotoxic and anticarcinogenic potential of <b>1</b> by the comet and aberrant crypt focus assays in the peripheral blood and colon of 4–5-week-old Wistar rats, respectively. The rats were exposed to 1,2-dimethylhydrazine (40 mg/kg) and were treated by gavage with doses of 10, 20, and 40 mg/kg of <b>1</b>. The results showed that the dose of 40 mg/kg was neither genotoxic nor carcinogenic. In the comet assay, all <b>1</b> doses displayed antigenotoxic effects. In addition, this compound (20 and 40 mg/kg) exhibited an anticarcinogenic effect in the aberrant crypt focus assay

Development and validation of a high-performance liquid chromatography method for quantification of egonol and homoegonol in Styrax species

Styrax camporum Pohl, known in Brazil as estoraque do campo or cuia de brejo, has been used in the treatment of gastrointestinal diseases. The therapeutic action of S. camporum has been attributed to the ethyl acetate fraction, although the chemical composition of this fraction has not yet been analyzed. In this study, a high-performance liquid chromatography photodiode array detection (HPLC-PAD) method for analysis of Brazilian Styrax species has been developed. The compounds egonol (1) and homoegonol (2) were found to be present in all the samples investigated by HPLC. These compounds were isolated by open column chromatography followed by preparative TLC, and were identified by 1H NMR. Compounds 1 and 2 were thus proposed as phytochemical markers for Styrax, owing to their biological properties and presence in other Styrax species. The developed method has been validated and successfully applied for quantification of 1 and 2 in S. camporum dried leaves and crude ethanolic extracts from S. ferrugineus and S. pohlii aerial parts. Copyright (c) 2011 John Wiley & Sons, Ltd.Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2008/10.283-1]Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Coordenadoria de Aperfeicoamento de Pessoal do Ensino SuperiorCoordenadoria de Aperfeicoamento de Pessoal do Ensino SuperiorConselho Nacional de Desenvolvimento Cientifico e TecnologicoConselho Nacional de Desenvolvimento Cientifico e Tecnologic