Patterns Of Seizure Control In Patients With Mesial Temporal Lobe Epilepsy With And Without Hippocampus Sclerosis [padrões De Controle De Crises Em Pacientes Com Epilepsia De Lobo Temporal Com Ou Sem Esclerose Hipocampal]

Objective: Patients with mesial temporal lobe epilepsy (MTLE) may present unstable pattern of seizures. We aimed to evaluate the occurrence of relapse-remitting seizures in MTLE with (MTLE-HS) and without (MTLE-NL) hippocampal sclerosis. Method: We evaluated 172 patients with MTLE-HS (122) or MTLE-NL (50). Relapse-remitting pattern was defined as periods longer than two years of seizure-freedom intercalated with seizure recurrence. “Infrequent seizures” was considered as up to three seizures per year and “frequent seizures” as any period of seizures higher than that. Results: Thirty-seven (30%) MTLE-HS and 18 (36%) MTLE-NL patients had relapse-remitting pattern (X2, p = 0.470). This was more common in those with infrequent seizures (X2, p < 0.001). Twelve MTLE-HS and one MTLE-NL patients had prolonged seizure remission between the first and second decade of life (X2, p = 0.06). Conclusion: Similar proportion of MTLE-HS or MTLE-NL patients present relapse-remitting seizures and this occurs more often in those with infrequent seizures.7327982Kwan, P., Brodie, M.J., Early identification of refractory epilepsy (2010) N Engl Jmed, 342 (5), pp. 314-319. , http://dx.doi.org/10.1056/NEJM200002033420503Goodridge, D.M., Shorvon, S.D., Epileptic seizures in a population of 6000. II: Treatment and prognosis (1983) Br Med J, 287 (6393), pp. 645-647. , http://dx.doi.org/10.1136/bmj.287.6393.645Brodie, M.J., Barry, S., Bamagous, G.A., Norrie, J.D., Kwan, P., Patterns of treatment response in newly diagnosed epilepsy (2012) Neurology, 78 (20), pp. 1548-1554. , http://dx.doi.org/10.1212/WNL.0b013e3182563b19Semah, F., Picot, M.C., Adam, C., Broglin, D., Arzimanoglou, A., Bazin, B., Is the underlying cause of epilepsy a major prognostic factor for recurrence? (1998) Neurology, 51 (5), pp. 1256-1262. , http://dx.doi.org/10.1212/WNL.51.5.1256Hauser, W.A., Annegers, J.F., Kurland, L.T., Prevalence of epilepsy in Rochester, Minnesota: 1940-1980 (1991) Epilepsia, 32 (4), pp. 429-445. , http://dx.doi.org/10.1111/j.1528-1157.1991.tb04675.xFrench, J.A., Williamson, P.D., Thadani, V.M., Darcey, T.M., Mattson, R.H., Spencer, S.S., Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination (1993) Ann Neurol, 34 (6), pp. 774-780. , http://dx.doi.org/10.1002/ana.410340604Berg, A.T., The natural history of mesial temporal lobe epilepsy (2008) Curr Opin Neurol, 21 (2), pp. 173-178. , http://dx.doi.org/10.1097/WCO.0b013e3282f36ccdSillanpää, M., Schmidt, D., Natural history of treated childhood-onset epilepsy: Prospective, long-term population based study (2006) Brain, 129, pp. 617-624. , http://dx.doi.org/10.1093/brain/awh726Coan, A.C., Kubota, B.Y., Bergo, F., Campos, B.M., Cendes, F., 3T MRI quantification of hippocampal volume and signal in mesial temporal lobe epilepsy improves detection of hippocampal sclerosis (2014) AJNR am J Neuroradiol, 35 (1), pp. 77-83. , http://dx.doi.org/10.3174/ajnr.A3640Wieser, H.G., ILAE Commission on Neurosurgery of Epilepsy. Mesial temporal lobe epilepsy with hippocampal sclerosis (2004) Epilepsia, 45 (6), pp. 695-714. , http://dx.doi.org/10.1111/j.0013-9580.2004.09004.xKwan, P., Arzimanoglou, A., Berg, A.T., Brodie, M.J., Allen Hauser, W., Mathern, G., Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies (2010) Epilepsia, 51 (6), pp. 1069-1077. , http://dx.doi.org/10.1111/j.1528-1167.2009.02397.xVan Paesschen, W., Connelly, A., King, M.D., Jackson, G.D., Duncan, J.S., The spectrum of hippocampal sclerosis: A quantitative magnetic resonance imaging study (1997) Ann Neurol, 41 (1), pp. 41-51. , http://dx.doi.org/10.1002/ana.410410109Cohen-Gadol, A.A., Bradley, C.C., Williamson, A., Kim, J.H., Westerveld, M., Duckrow, R.B., Normal magnetic resonance imaging and medial temporal lobe epilepsy: The clinical syndrome of paradoxical temporal lobe epilepsy (2005) J Neurosur, 102 (5), pp. 902-909. , http://dx.doi.org/10.3171/jns.2005.102.5.0902Pittau, F., Bisulli, F., Mai, R., Fares, J.E., Vignatelli, L., Labate, A., Prognostic factors in patients with mesial temporal lobe epilepsy (2009) Epilepsia, 50, pp. 41-44. , http://dx.doi.org/10.1111/j.1528-1167.2008.01969.xKobayashi, E., Lopes-Cendes, I., Guerreiro, C.A., Sousa, S.C., Guerreiro, M.M., Cendes, F., Seizure outcome and hippocampal atrophy in familial mesial temporal lobe epilepsy (2001) Neurology, 56 (2), pp. 166-172. , http://dx.doi.org/10.1212/WNL.56.2.166Labate, A., Gambardella, A., Ermann, E., Aguglia, U., Cendes, F., Berkovic, S.F., Benign mesial temporal lobe epilepsy (2011) Nat Rev Neurol, 7 (4), pp. 237-240. , http://dx.doi.org/10.1038/nrneurol.2010.21

Reproducibility in the absence of selective reporting : An illustration from large-scale brain asymmetry research

Altres ajuts: Max Planck Society (Germany).The problem of poor reproducibility of scientific findings has received much attention over recent years, in a variety of fields including psychology and neuroscience. The problem has been partly attributed to publication bias and unwanted practices such as p-hacking. Low statistical power in individual studies is also understood to be an important factor. In a recent multisite collaborative study, we mapped brain anatomical left-right asymmetries for regional measures of surface area and cortical thickness, in 99 MRI datasets from around the world, for a total of over 17,000 participants. In the present study, we revisited these hemispheric effects from the perspective of reproducibility. Within each dataset, we considered that an effect had been reproduced when it matched the meta-analytic effect from the 98 other datasets, in terms of effect direction and significance threshold. In this sense, the results within each dataset were viewed as coming from separate studies in an "ideal publishing environment," that is, free from selective reporting and p hacking. We found an average reproducibility rate of 63.2% (SD = 22.9%, min = 22.2%, max = 97.0%). As expected, reproducibility was higher for larger effects and in larger datasets. Reproducibility was not obviously related to the age of participants, scanner field strength, FreeSurfer software version, cortical regional measurement reliability, or regional size. These findings constitute an empirical illustration of reproducibility in the absence of publication bias or p hacking, when assessing realistic biological effects in heterogeneous neuroscience data, and given typically-used sample sizes

Fast, Accurate And Precise Mid-sagittal Plane Location In 3d Mr Images Of The Brain

Extraction of the mid-sagittal plane (MSP) is a key step for brain image registration and asymmetry analysis. We present a fast MSP extraction method for 3D MR images, based on automatic segmentation of the brain and on heuristic maximization of the cerebro-spinal fluid within the MSP. The method is robust to severe anatomical asymmetries between the hemispheres, caused by surgical procedures and lesions. The method is also accurate with respect to MSP delineations done by a specialist. The method was evaluated on 64 MR images (36 pathological, 20 healthy, 8 synthetic), and it found a precise and accurate approximation of the MSP in all of them with a mean time of 60.0 seconds per image, mean angular variation within a same image (precision) of 1.26° and mean angular difference from specialist delineations (accuracy) of 1.64°. © 2008 Springer-Verlag.25 CCIS278290Davidson, R.J., Hugdahl, K., (1996) Brain Asymmetry, , MIT Press/Bradford BooksCrow, T.J., Schizophrenia as an anomaly of cerebral asymmetry (1993) Imaging of the Brain in Psychiatry and Related Fields, pp. 3-17. , Maurer, K. (ed.) Springer, HeidelbergGeschwind, N., Levitsky, W., Human brain: Left-right asymmetries in temporale speech region (1968) Science, 161, pp. 186-187Wang, L., Joshi, S.C., Miller, M.I., Csernansky, J.G., Statistical analysis of hippocampal asymmetry in schizophrenia (2001) NeuroImage, 14, pp. 531-545Csernansky, J.G., Joshi, S., Wang, L., Haller, J.W., Gado, M., Miller, J.P., Grenander, U., Miller, M.I., Hippocampal morphometry in schizophrenia by high dimensional brain mapping (1998) Proceedings of the National Academy of Sciences of the United States of America, 95, pp. 11406-11411Styner, M., Gerig, G., Hybrid boundary-medial shape description for biologically variable shapes (2000) Proc. of IEEEWorkshop on Mathematical Methods in Biomedical Imaging Analysis (MMBIA), pp. 235-242. , IEEE, Los AlamitosMackay, C.E., Barrick, T.R., Roberts, N., DeLisi, L.E., Maes, F., Vandermeulen, D., Crow, T.J., Application of a new image analysis technique to study brain asymmetry in schizophrenia (2003) Psychiatry Research, 124, pp. 25-35Highley, J.R., DeLisi, L.E., Roberts, N., Webb, J.A., Relja, M., Razi, K., Crow, T.J., Sex-dependent effects of schizophrenia: An MRI study of gyral folding, and cortical and white matter volume (2003) Psychiatry Research: Neuroimaging, 124, pp. 11-23Barrick, T.R., Mackay, C.E., Prima, S., Maes, F., Vandermeulen, D., Crow, T.J., Roberts, N., Automatic analysis of cerebral asymmetry: Na exploratory study of the relationship between brain torque and planum temporale asymmetry (2005) NeuroImage, 24, pp. 678-691Hogan, R.E., Mark, K.E., Choudhuri, I., Wang, L., Joshi, S., Miller, M.I., Bucholz, R.D., Magnetic resonance imaging deformation-based segmentation of the hippocampus in patientswith mesial temporal sclerosis and temporal lobe epilepsy (2000) J. Digital Imaging, 13, pp. 217-218Wu, W.C., Huang, C.C., Chung, H.W., Liou, M., Hsueh, C.J., Lee, C.S., Wu, M.L., Chen, C.Y., Hippocampal alterations in children with temporal lobe epilepsy with or without a history of febrile convulsions: Evaluations with MR volumetry and proton MR spectroscopy (2005) AJNR Am. J. Neuroradiol., 26, pp. 1270-1275Csernansky, J.G., Wang, L., Joshi, S., Miller, J.P., Gado, M., Kido, D., McKeel, D., Miller, M.I., Early DAT is distinguished from aging by High-dimensional Mapping of the hippocampus (2000) Neurology, 55, pp. 1636-1643Liu, Y., Teverovskiy, L.A., Lopez, O.L., Aizenstein, H., Meltzer, C.C., Becker, J.T., Discovery of biomarkers for alzheimer's disease prediction from structural MR images (2007) 2007 IEEE Intl. Symp. on Biomedical Imaging, pp. 1344-1347. , IEEE, Los AlamitosArdekani, B., Kershaw, J., Braun, M., Kanno, I., Automatic detection of the mid-sagittal plane in 3-D brain images (1997) IEEE Trans. on Medical Imaging, 16, pp. 947-952Kapouleas, I., Alavi, A., Alves, W.M., Gur, R.E., Weiss, D.W., Registration of three dimensional MR and PET images of the human brain without markers (1991) Radiology, 181, pp. 731-739Liu, Y., Collins, R.T., Rothfus, W.E., Robust midsagittal plane extraction from normal and pathological 3D neuroradiology images (2001) IEEE Trans. on Medical Imaging, 20, pp. 175-192Talairach, J., Tournoux, P., (1988) Co-Planar Steriotaxic Atlas of the Human Brain, , Thieme Medical PublishersBergo, F.P.G., Ruppert, G.C.S., Pinto, L.F., Falcão, A.X., Fast and robust mid-sagittal plane location in 3D MR images of the brain (2008) Proc. BIOSIGNALS 2008 - Intl. Conf. on Bio- Inspired Syst. and Sig. Proc., pp. 92-99Junck, L., Moen, J.G., Hutchins, G.D., Brown, M.B., Kuhl, D.E., Correlation methods for the centering, rotation, and alignment of functional brain images (1990) The Journal of Nuclear Medicine, 31, pp. 1220-1226Minoshima, S., Berger, K.L., Lee, K.S., Mintun, M.A., An automated method for rotational correction and centering of three-dimensional functional brain images (1992) The Journal of Nuclear Medicine, 33, pp. 1579-1585Sun, C., Sherrah, J., 3D symmetry detection using the extended Gaussian image (1997) IEEE Trans. on Pattern Analysis and Machine Intelligence, 19, pp. 164-168Smith, S.M., Jenkinson, M., Accurate robust symmetry estimation (1999) LNCS, 1679, pp. 308-317. , Taylor, C., Colchester, A. (eds.) MICCAI 1999. Springer, HeidelbergPrima, S., Ourselin, S., Ayache, N., Computation of the mid-sagittal plane in 3D brain images (2002) IEEE Trans. on Medical Imaging, 21, pp. 122-138Tuzikov, A.V., Colliot, O., Bloch, I., Evaluation of the symmetry plane in 3D MR brain images (2003) Pattern Recognition Letters, 24, pp. 2219-2233Teverovskiy, L., Liu, Y., Truly 3D midsagittal plane extraction for robust neuroimage registration (2006) Proc. of 3rd IEEE Intl. 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Constituintes químicos fixos e voláteis dos talos e frutos de Piper tuberculatum Jacq. e das raízes de P. hispidum H. B. K. Fixed and volatile chemical constituents from stems and fruits of Piper tuberculatum Jacq. and from roots of P. hispidum H. B. K.

Os óleos essenciais dos frutos e talos finos de Piper tuberculatum e das raízes de P. hispidum, coletados no estado de Rondônia, foram obtidos por hidrodestilação e analisados por GC e GC-MS. Foram identificados como constituintes majoritários, nos óleos dos frutos e talos finos de P. tuberculatum, o óxido de cariofileno (32,1%) e (26,6%) e o (E)-cariofileno (17,7%) e (12,3%), respectivamente. No óleo essencial das raízes de P. hispidum, foram identificados, como constituintes majoritários, o dilapiol (57,5%), a elemicina (24,5%) e o apiol (10,2%). Do extrato etanólico dos frutos de P. tuberculatum, foram isolados os esteróides &#946;-sitosterol e estigmasterol, as amidas piplartina e dihidropiplartina e um derivado do ácido cinâmico, o ácido 3,4,5-trimetoxi-dihidrocinâmico.<br>The essential oils of the fruits and fine stems of Piper tuberculatum and of the roots of P. hispidum, collected in the state of Rondônia, had been gotten by hydrodistillation and analyzed by GC and GC-MS. Caryophyllene oxide - 32,1% in fruits and 26,6% in fine stem, and (E)-caryophyllene - 17,7% in fruits and 12,3% in fine stems, were identified as the major constituents in such parts of P. tuberculatum. In the essential oil of the roots of P. hispidum, dillapiol (57,5%), elemicine (24,5%) and apiole (10,2%) were identified as the most abundant constituents. From the ethanolic extract of the fruits of P. tuberculatum, the steroids &#946;-sitosterol and stigmasterol, the amides piplartine and dihidropiplartine and the derivative of the cinâmico acid 3,4,5-trimethoxy-dihidrocinâmic acid were isolated