Model-based Design of a Solar Driven Hybrid System for Space Heating and DHW Preparation of a Multifamily House☆

Abstract Following the most recent European Directives on Energy Performance of Buildings and Energy Efficiency, new solutions for DHW production, space heating and cooling have to be developed and applied to reduce the primary energy consumption of residential buildings. Due to the complexity of installation and control, H&C hybrid systems exploiting a mix of conventional fuels and RES are not yet widespread although they can bring important savings to the yearly building energy consumptions. This work summarizes the parametric analysis used as part of the design process of a hybrid system for the retrofit of a multifamily house located in Madrid, and shows how heating, cooling and DHW demands of multifamily houses can be covered by a heat pump plus solar systems, integrating a high share of RES. The design of the system has taken into account energy savings, economics and architectural aspects

Black Hole entropy for two higher derivative theories of gravity

The dark energy issue is focusing the attention of an incresing number of physicists all over the world. Among the possible alternatives in order to explain what as been named the "Mystery of the Millennium" are the so-called Modified Theories of Gravity. A crucial test for such models is represented by the existence and (if this is the case) the properties of their black hole solutions. Nowadays, to our knowledge, only two non-trivial, spherically symmetric, solutions with vanishing cosmological constant are known by Barrow & Clifton (2005) and Deser, Sarioglu & Tekin (2008). Aim of the paper is to discuss some features of such solutions, with emphasis on their thermodynamic properties such as entropy and temperature, little progress being possible along the way which leads to a consistent definition of mass.Comment: 10 pages, 1 figur

High resolution spectroscopy in the XUV with pairs of mutually coherent and time-delayed laser harmonics

We present a Ramsey technique using high-order harmonics for high-resolution atomic spectroscopy in the extreme ultraviolet. Pairs of time-delayed and phase-coherent harmonic pulses generated by the interaction of ultrashort and intense laser pulses with a noble gas are used to study excited states of krypton

YaDT-Drb : Yet another Decision Tree Domain Rule builder

Viene presentata la progettazione e l'implementazione di un algortimo per la classficazione che integra conoscenza deduttiva. Particolare attenzione è stata posta alla performance con l'uso delle tecniche di base implementate nell'algoritmo YaDT del Prof. Salvatore Ruggieri

Effects of opioids on proximal renal tubular cells undergoing ATP depletion.

Abstract This study investigated the effect of morphine, fentanyl, butorphanol and buprenorphine on viability and caspase-3 activity in renal proximal tubular cells exposed to opioids for 2 h before or 12 h after chemical anoxia. Cell viability decreased regardless the treatment although intracellular ATP content was elevated in morphine and fentanyl pre-treated cells at 12 h. Anoxia increased caspase activity but this effect was significantly reduced in cells treated before or after with morphine, fentanyl and in cell treated with butorphanol for 12 h. No influence of buprenorphine was detected. Morphine, fentanyl and butorphanol might have protective effects during kidney ischemia

Correction: Equilibrium gels of low-valence DNA nanostars: a colloidal model for strong glass formers

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MIME - A Formal Approach for Multiple Investigation in (Android) Malware Emulation Analysis

In this paper, we propose a new dynamic and configurable approach to anti-emulation malware analysis, aiming at improving transparency of existing analyses techniques. First of all, we test the effectiveness of existing widespread free analyzers. We observe that the main problem of these analyses is that they provide static and immutable values to the parameter used in anti-emulation tests. Our approach aims at overcoming these limitations by providing an abstract non-interference-based approach modeling the fact that parameters can be modified dynamically, and the corresponding executions compared

Analysis of the shear stresses in a filling line of parenteral products

Drug manufacturing consists of a series of operations, generally referred to as formulation, filling, and finishing. Filling represents the most critical step, in which the drug product undergoes different processes, including mixing, pumping, filtration, and final filling into vials. As filling lines operate under faster and faster conditions, there is concern over stability of protein-based products, which may be sensitive to temperature changes, oxidation, light, ionic strength and shear stress. Among these, shear stress has gained interest over the past decades because of its frequent occurrence in filling lines. Exposure of protein-based parenteral drugs to such stresses is believed to promote unfolding and subsequent aggregation, which might alter the biological activity of the drug and raise the potential for side effects. Several studies conducted in recent years have tried to shed light on the actual impact of shear stress on drug products, but the presence of additional stresses (such as interfacial stress) has complicated the interpretation of the results. In this controversial landscape, it is therefore necessary to quantify shear stress in the operating units of the filling process as a first step for broader experimental investigations. Therefore, starting from some typical operating units, we developed a model for calculating the shear stress distribution using a shear history-based approach. In detail, we considered a representative number of particles within the domain and followed their trajectories, which allowed us to determine the average shear stress. Several operating units were analyzed and the resulting shear stress exposures were determined. The field of scale-down approaches, used to scale the commercial process down to the laboratory level, was also explored. They allow to perform product characterization experiments using smaller volumes of the drug products. A new approach for scaling down the commercial process was proposed, which was compared with traditional approaches and shown to provide greater representativeness between the two scales