Radiological Spectrum of von Hippel-Lindau disease – A Case Report

Von Hippel-Lindau (VHL) disease is an autosomal dominant genetic disorder resulting from inactivation of tumor suppressiongenes located at the chromosome 3p 25.5. VHL comprises of many benign and malignant tumors along affecting varioussystems of the body with variable manifestations. A wide variation in radiological spectrum is seen as per the involvement ofparticular system or organ. The imaging modalities like Ultrasonogrphy (USG), Computerized Tomography (CT) andMagnetic Resonance Imaging (MRI) play an important role in diagnosing and treating the affected individuals. These also playequally important role in the screening and follow up of such cases. We present a case of an 18 year old female, who wasdiagnosed with VHL at the age of 10 years, where imaging modalities helped her management and follow up

Mayer-Rokitansky-Kuster-Hauser Type I Syndrome - A Case Report

Mayer-Rokitansky-Kuster-Hauser (MRKH) Syndrome is not uncommon as this is a part of the Mullerian agenesis. This isusually diagnosed during adolescent period when signs and symptoms of the ongoing changes in female body type are delayed.We present 17 years old adolescent female who presented with primary amenorrhoea as the normal menstruation did not startat puberty. She was diagnosed as MRKH Type I Syndrome on the basis of radiological investigations

Clinico-radiological correlation of Primary Multifocal Osseous NHL

Multifocal skeletal involvement in primary non-Hodgkin’s Lymphoma (NHL) is very rare as compared to the focal one. Thesefindings of multifocal nature are more common in children than in adults. We present 52 years old male patient who presentedwith slow growing multiple tender swellings on the left side of mandible and on the medial end of right first rib. We presentthe clinico-radiological aspects of the disease which lead to suspicion of the NHL and later proved to be primary non-Hodgkin’s Lymphoma on fine needle aspiration cytology

Hyperphosphaturic Mesenchymal Tumor induced Osteomalacia– A Case Report

Hyperphosphaturic Mesenchymal Tumor (HMT) is a very rare benign tumor of the soft tissue or bone which produces tumorinduced osteomalacia, also called as oncogenic osteomalacia. This activity can only be stopped by the surgical removal of thetumor. We present a 23 years old man who presented with long standing bony pains without any relief by a variety ofmedications. The clue to the diagnosis was taken from pelvis skiagram, Magnetic Resonance Imaging (MRI) of the body, PETscan and the blood chemistry

Radiological diagnosis of Cysticercosis of Breast - An unusual presentation

Breast cysticercosis manifestation is usually uncommon and only a few cases have been reported in the literature. Thismanifests in the form of signs and symptoms which normally do not point towards the diagnosis. The radiological modalitiesalways narrow down the gap between the complaints and the diagnosis. We present a case with cysticercus cysts in breastparenchyma as well as in both pectoral muscles which was suspected on ultrasonography (USG) and diagnosed on MagneticResonance Imaging (MRI). The patient responded to the medical treatment conservatively thus avoiding excisional biopsy.Follow up and repeat MRI has confirmed the cure of the complaints as well as the disease

Bounded Verification with On-the-Fly Discrepancy Computation

Simulation-based verification algorithms can provide formal safety guarantees for nonlinear and hybrid systems. The previous algorithms rely on user provided model annotations called discrepancy function, which are crucial for computing reachtubes from simulations. In this paper, we eliminate this requirement by presenting an algorithm for computing piece-wise exponential discrepancy functions. The algorithm relies on computing local convergence or divergence rates of trajectories along a simulation using a coarse over-approximation of the reach set and bounding the maximal eigenvalue of the Jacobian over this over-approximation. The resulting discrepancy function preserves the soundness and the relative completeness of the verification algorithm. We also provide a coordinate transformation method to improve the local estimates for the convergence or divergence rates in practical examples. We extend the method to get the input-to-state discrepancy of nonlinear dynamical systems which can be used for compositional analysis. Our experiments show that the approach is effective in terms of running time for several benchmark problems, scales reasonably to larger dimensional systems, and compares favorably with respect to available tools for nonlinear models.Comment: 24 page

Importance of Conventional Radiography in Diagnosis and Management of Giant Cell Tumour at an unusual location

Giant cell tumour (GCT) or osteoclastoma of the bone is mostly benign but locally aggressive primary tumour of unknownorigin occurring at epiphysis. It is a tumour of long bones and rarely seen in bones of hand and foot. The cases are reported intarsal and carpal bone but involvement of metatarsal bone is very rare. We present a case of twenty years old female patientwith GCT of second metatarsal of left foot. The patient underwent aggressive curettage and filling with bone chips and is onregular follow up

Estimating Entropy of Liquids from Atom-Atom Radial Distribution Functions: Silica, Beryllium Fluoride and Water

Molecular dynamics simulations of water, liquid beryllium fluoride and silica melt are used to study the accuracy with which the entropy of ionic and molecular liquids can be estimated from atom-atom radial distribution function data. All three systems are known to display similar liquid-state thermodynamic and kinetic anomalies due to a region of anomalous excess entropy behaviour where entropy rises on isothermal compression. The pair correlation entropy is demonstrated to be sufficiently accurate that the density-temperature regime of anomalous behaviour as well as the strength of the entropy anomaly can be predicted reliably for both ionic melts as well as different rigid-body pair potentials for water. Errors in the total thermodynamic entropy for ionic melts due to the pair correlation approximation are of the order of 10% or less for most state points but can be significantly larger in the anomalous regime at very low temperatures. In the case of water, as expected given the rigid-body constraints for a molecular liquids, the pair correlation approximation causes significantly larger errors, between 20 and 30%, for most state points. Comparison of the excess entropy, Se, of ionic melts with the pair correlation entropy, S2, shows that the temperature dependence of Se is well described by T ??2=5 scaling across both the normal and anomalous regimes, unlike in the case of S2. As a function of density, the Se(rho) curves shows only a single maximum while the S2(rho) curves show both a maximum and a minimum. These differences in the behaviour of S2 and Se are due to the fact that the residual multiparticle entropy, delta(S) = Se - S2, shows a strong negative correlation with tetrahedral order in the anomalous regime.Comment: 30 pages, 8 figure

Monitoring and evaluating capacity building activities in low and middle income countries: challenges and opportunities.

BACKGROUND: Lower and middle income countries (LMICs) are home to >80% of the global population, but mental health researchers and LMIC investigator led publications are concentrated in 10% of LMICs. Increasing research and research outputs, such as in the form of peer reviewed publications, require increased capacity building (CB) opportunities in LMICs. The National Institute of Mental Health (NIMH) initiative, Collaborative Hubs for International Research on Mental Health reaches across five regional 'hubs' established in LMICs, to provide training and support for emerging researchers through hub-specific CB activities. This paper describes the range of CB activities, the process of monitoring, and the early outcomes of CB activities conducted by the five research hubs. METHODS: The indicators used to describe the nature, the monitoring, and the early outcomes of CB activities were developed collectively by the members of an inter-hub CB workgroup representing all five hubs. These indicators included but were not limited to courses, publications, and grants. RESULTS: Results for all indicators demonstrate a wide range of feasible CB activities. The five hubs were successful in providing at least one and the majority several courses; 13 CB recipient-led articles were accepted for publication; and nine grant applications were successful. CONCLUSIONS: The hubs were successful in providing CB recipients with a wide range of CB activities. The challenge remains to ensure ongoing CB of mental health researchers in LMICs, and in particular, to sustain the CB efforts of the five hubs after the termination of NIMH funding

Wideband THz time domain spectroscopy based on optical rectification and electro-optic sampling

We present an analytical model describing the full electromagnetic propagation in a THz time-domain spectroscopy (THz-TDS) system, from the THz pulses via Optical Rectification to the detection via Electro Optic-Sampling. While several investigations deal singularly with the many elements that constitute a THz-TDS, in our work we pay particular attention to the modelling of the time-frequency behaviour of all the stages which compose the experimental set-up. Therefore, our model considers the following main aspects: (i) pump beam focusing into the generation crystal; (ii) phase-matching inside both the generation and detection crystals; (iii) chromatic dispersion and absorption inside the crystals; (iv) Fabry-Perot effect; (v) diffraction outside, i.e. along the propagation, (vi) focalization and overlapping between THz and probe beams, (vii) electro-optic sampling. In order to validate our model, we report on the comparison between the simulations and the experimental data obtained from the same set-up, showing their good agreement