Reduced incidence of hypertension after heterotopic cardiac transplantation compared with orthotopic cardiac transplantation Evidence that excision of the native heart contributes to post-transplant hypertension

ObjectivesThis study was designed to test the hypothesis that heterotopic heart transplant (HHT) patients have lower blood pressure than orthotopic cardiac transplant (OCT) patients because their native heart is involved in blood pressure homeostasis.BackgroundHypertension occurs more frequently after OCT than after liver or lung transplantation, suggesting that transplantation of the heart itself contributes to post-transplant hypertension.MethodsBlood pressure and related measurements in 233 OCT and 38 HHT patients were studied retrospectively post-transplant.ResultsSystolic blood pressure (SBP) was persistently lower among HHT patients (means 121 vs. 137, 126 vs. 137, 125 vs. 139, and 128 vs. 143 mm Hg at month 3 and years 1, 3, and 5 respectively, p < 0.005). Left ventricular and aortic systolic pressures were also lower (130 vs. 143 mm Hg, p = 0.01 and 129 vs. 142 mm Hg, p = 0.01). Multivariable analysis with age, gender, body mass index, creatinine, steroids, cyclosporine, use of antihypertensive medication, donor left ventricular ejection fraction, donor weight, and type of transplant as covariables showed HHT to be independently associated with a lower SBP at each time point (beta-coefficients −16.2, −12.1, −13.3, and −14.2 mm Hg, p < 0.01). The adjusted hazard ratio for the development of systolic hypertension among HHT compared with OCT patients was 0.59 (95% confidence interval 0.39 to 0.91, p = 0.017).ConclusionsHeterotopic heart transplant patients had lower SBP than OCT patients, consistent with the hypothesis that the native heart continues to contribute to blood pressure homeostasis

Heterotic String Field Theory

We construct the Neveu-Schwarz sector of heterotic string field theory using the large Hilbert space of the superghosts and the multi-string products of bosonic closed string field theory. No picture-changing operators are required as in Wess-Zumino-Witten-like open superstring field theory. The action exhibits a novel kind of nonpolynomiality: in addition to terms necessary to cover missing regions of moduli spaces, new terms arise from the boundary of the missing regions and its subspaces. We determine the action up to quintic order and a subset of terms to all orders.Comment: 15 pages, no figures, LaTeX2e; v2: minor cosmetic change

Decoherence and CPT Violation in a Stringy Model of Space-Time Foam

I discuss a model inspired from the string/brane framework, in which our Universe is represented as a three brane, propagating in a bulk space time punctured by D0-brane (D-particle) defects. As the D3-brane world moves in the bulk, the D-particles cross it, and from an effective observer on D3 the situation looks like a ``space-time foam'' with the defects ``flashing'' on and off (``D-particle foam''). The open strings, with their ends attached on the brane, which represent matter in this scenario, can interact with the D-particles on the D3-brane universe in a topologically non-trivial manner, involving splitting and capture of the strings by the D0-brane defects. Such processes are described by logarithmic conformal field theories on the world-sheet. Physically, they result in effective decoherence of the string matter on the D3 brane, and as a result, of CPT Violation, but of a type that implies an ill-defined nature of the effective CPT operator. Due to electric charge conservation, only electrically neutral (string) matter can exhibit such interactions with the D-particle foam. This may have unique, experimentally detectable, consequences for electrically-neutral entangled quantum matter states on the brane world, in particular the modification of the pertinent EPR Correlation of neutral mesons in a meson factory.Comment: 41 pages Latex, five eps figures incorporated. Uses special macro

WZW-like Action for Heterotic String Field Theory

We complete the construction of the Neveu-Schwarz sector of heterotic string field theory begun in hep-th/0406212 by giving a closed-form expression for the action and gauge transformations. Just as the Wess-Zumino-Witten (WZW) action for open superstring field theory can be constructed from pure-gauge fields in bosonic open string field theory, our heterotic string field theory action is constructed from pure-gauge fields in bosonic closed string field theory. The construction involves a simple alternative form of the WZW action which is consistent with the algebraic structures of closed string field theory.Comment: 22 pages, no figures, LaTeX2

Crack paths under mixed mode loading

Long fatigue cracks that initially experience mixed mode displacements usually change direction in response to cyclic elastic stresses. Eventually the cracks tend to orient themselves into a pure mode I condition, but the path that they take can be complex and chaotic. In this paper, we report on recent developments in techniques for tracking the crack path as it grows and evaluating the strength of the mixed mode crack tip stress field

Single-crossover dynamics: finite versus infinite populations

Populations evolving under the joint influence of recombination and resampling (traditionally known as genetic drift) are investigated. First, we summarise and adapt a deterministic approach, as valid for infinite populations, which assumes continuous time and single crossover events. The corresponding nonlinear system of differential equations permits a closed solution, both in terms of the type frequencies and via linkage disequilibria of all orders. To include stochastic effects, we then consider the corresponding finite-population model, the Moran model with single crossovers, and examine it both analytically and by means of simulations. Particular emphasis is on the connection with the deterministic solution. If there is only recombination and every pair of recombined offspring replaces their pair of parents (i.e., there is no resampling), then the {\em expected} type frequencies in the finite population, of arbitrary size, equal the type frequencies in the infinite population. If resampling is included, the stochastic process converges, in the infinite-population limit, to the deterministic dynamics, which turns out to be a good approximation already for populations of moderate size.Comment: 21 pages, 4 figure

Casimir energy of a compact cylinder under the condition ϵμ=c−2\epsilon\mu = c^{-2}

The Casimir energy of an infinite compact cylinder placed in a uniform unbounded medium is investigated under the continuity condition for the light velocity when crossing the interface. As a characteristic parameter in the problem the ratio $\xi^2=(\epsilon_1-\epsilon_2)^2/ (\epsilon_1+\epsilon_2)^-2 = (\mu_1-\mu_2)^2/(\mu_1+ \mu_2)^2 \le 1$ is used, where $\epsilon_1$ and $\mu_1$ are, respectively, the permittivity and permeability of the material making up the cylinder and $\epsilon_2$ and $\mu_2$ are those for the surrounding medium. It is shown that the expansion of the Casimir energy in powers of this parameter begins with the term proportional to $\xi^4$. The explicit formulas permitting us to find numerically the Casimir energy for any fixed value of $\xi^2$ are obtained. Unlike a compact ball with the same properties of the materials, the Casimir forces in the problem under consideration are attractive. The implication of the calculated Casimir energy in the flux tube model of confinement is briefly discussed.Comment: REVTeX, 12 pages, 1 figure in a separate fig1.eps file, 1 table; minor corrections in English and misprints; version to be published in Phys. Rev. D1

Equivalence between free quantum particles and those in harmonic potentials and its application to instantaneous changes

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedIn quantum physics the free particle and the harmonically trapped particle are arguably the most important systems a physicist needs to know about. It is little known that, mathematically, they are one and the same. This knowledge helps us to understand either from the viewpoint of the other. Here we show that all general time-dependent solutions of the free-particle Schrodinger equation can be mapped to solutions of the Schrodinger equation for harmonic potentials, both the trapping oscillator and the inverted `oscillator'. This map is fully invertible and therefore induces an isomorphism between both types of system, they are equivalent. A composition of the map and its inverse allows us to map from one harmonic oscillator to another with a different spring constant and different center position. The map is independent of the state of the system, consisting only of a coordinate transformation and multiplication by a form factor, and can be chosen such that the state is identical in both systems at one point in time. This transition point in time can be chosen freely, the wave function of the particle evolving in time in one system before the transition point can therefore be linked up smoothly with the wave function for the other system and its future evolution after the transition point. Such a cut-and-paste procedure allows us to describe the instantaneous changes of the environment a particle finds itself in. Transitions from free to trapped systems, between harmonic traps of different spring constants or center positions, or, from harmonic binding to repulsive harmonic potentials are straightforwardly modelled. This includes some time dependent harmonic potentials. The mappings introduced here are computationally more efficient than either state-projection or harmonic oscillator propagator techniques conventionally employed when describing instantaneous (non-adiabatic) changes of a quantum particle's environmentPeer reviewe

Fluctuations, dissipation and the dynamical Casimir effect

Vacuum fluctuations provide a fundamental source of dissipation for systems coupled to quantum fields by radiation pressure. In the dynamical Casimir effect, accelerating neutral bodies in free space give rise to the emission of real photons while experiencing a damping force which plays the role of a radiation reaction force. Analog models where non-stationary conditions for the electromagnetic field simulate the presence of moving plates are currently under experimental investigation. A dissipative force might also appear in the case of uniform relative motion between two bodies, thus leading to a new kind of friction mechanism without mechanical contact. In this paper, we review recent advances on the dynamical Casimir and non-contact friction effects, highlighting their common physical origin.Comment: 39 pages, 4 figures. Review paper to appear in Lecture Notes in Physics, Volume on Casimir Physics, edited by Diego Dalvit, Peter Milonni, David Roberts, and Felipe da Rosa. Minor changes, a reference adde

Modelling mucociliary clearance

Mathematical modelling of the fluid mechanics of mucociliary clearance (MCC) is reviewed and future challenges for researchers are discussed. The morphology of the bronchial and tracheal airway surface liquid (ASL) and ciliated epithelium are briefly introduced. The cilia beat cycle, beat frequency and metachronal coordination are described, along with the rheology of the mucous layer. Theoretical modelling of MCC from the late 1960s onwards is reviewed, and distinctions between ‘phenomenological’, ‘slender body theory’ and recent ‘fluid–structure interaction’ models are explained.\ud \ud The ASL consists of two layers, an overlying mucous layer and underlying watery periciliary layer (PCL) which bathes the cilia. Previous models have predicted very little transport of fluid in the PCL compared with the mucous layer. Fluorescent tracer transport experiments on human airway cultures conducted by Matsui et al. [Matsui, H., Randell, S.H., Peretti, S.W., Davis, C.W., Boucher, R.C., 1998. Coordinated clearance of periciliary liquid and mucus from airway surfaces. J. Clin. Invest. 102 (6), 1125–1131] apparently showed equal transport in both the PCL and mucous layer. Recent attempts to resolve this discrepancy by the present authors are reviewed, along with associated modelling findings. These findings have suggested new insights into the interaction of cilia with mucus due to pressure gradients associated with the flat PCL/mucus interface. This phenomenon complements previously known mechanisms for ciliary propulsion. Modelling results are related to clinical findings, in particular the increased MCC observed in patients with pseudohypoaldosteronism. Recent important advances by several groups in modelling the fluid–structure interaction by which the cilia movement and fluid transport emerge from specification of internal mechanics, viscous and elastic forces are reviewed. Finally, we discuss the limitations of existing work, and the challenges for the next generation of models, which may provide further insight into this complex and vital system