Automação da semeadura de séries diferenciais no processo de identificação de raças de ferrugem da folha do trigo.

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Resultados da XIª, XIIª, XIIIª e XIVª coleção para avaliação e coleta de ferrugem do colmo e ferrugem da folha do trigo 1998-2001.

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Comportamento a ferrugem da folha das cultivares de trigo recomendadas para o cultivo no RS em 1984.

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Región y nación: el Río Grande insurgente, entre el Imperio de Brasil y las repúblicas del Río de la Plata (1838-1842)

El siglo diecinueve fue marcado por el proceso de descolonización y el consecuente proceso de formación de los Estados nacionales en Latinoamérica. Durante muchos años las guerras civiles entre diferentes grupos políticos fueron la característica más visible de aquellos tiempos. El artículo presente busca una explicación para la secesión de la provincia brasileña del Rio Grande do Sul ubicada en el extremo surdel país, en la frontera con el Estado Oriental del Uruguay y la Confederación Argentina. Los insurgentes proclamaron su independencia del Imperio de Brasil bajo el nombre de República Rio-Grandense, tratando desde luego de firmar compromisos políticos y económicoscon las repúblicas vecinas como una manera de asegurarse contra los esfuerzos del gobierno brasileño en reintegrar su provincia desgarrada. La República Rio-Grandense se mantuvo desde 1836 hasta 1845, pero el texto muestra los actos diplomáticos más importantes de los rebelados, que ocurrieron entre 1838 y 1842

Reação à ferrugem da folha das cultivares de trigo recomendadas para o cultivo no RS e SC em 1983.

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Cell-type-specific resolution epigenetics without the need for cell sorting or single-cell biology.

High costs and technical limitations of cell sorting and single-cell techniques currently restrict the collection of large-scale, cell-type-specific DNA methylation data. This, in turn, impedes our ability to tackle key biological questions that pertain to variation within a population, such as identification of disease-associated genes at a cell-type-specific resolution. Here, we show mathematically and empirically that cell-type-specific methylation levels of an individual can be learned from its tissue-level bulk data, conceptually emulating the case where the individual has been profiled with a single-cell resolution and then signals were aggregated in each cell population separately. Provided with this unprecedented way to perform powerful large-scale epigenetic studies with cell-type-specific resolution, we revisit previous studies with tissue-level bulk methylation and reveal novel associations with leukocyte composition in blood and with rheumatoid arthritis. For the latter, we further show consistency with validation data collected from sorted leukocyte sub-types

A Generalized Approach for Testing the Association of a Set of Predictors with an Outcome: A Gene Based Test

In many analyses, one has data on one level but desires to draw inference on another level. For example, in genetic association studies, one observes units of DNA referred to as SNPs, but wants to determine whether genes that are comprised of SNPs are associated with disease. While there are some available approaches for addressing this issue, they usually involve making parametric assumptions and are not easily generalizable. A statistical test is proposed for testing the association of a set of variables with an outcome of interest. No assumptions are made about the functional form relating the variables to the outcome. A general function is fit using any statistical learning algorithm, with the SuperLearner algorithm suggested. The parameter of interest is the cross-validated risk and this is compared to an expected risk. A Wald test is proposed using the influence curve of the cross-validated risk to obtain the variance. It is shown both theoretically and via simulation that the test maintains appropriate type I error control and is more powerful than parametric tests under more general alternatives. The test is applied to an MS candidate gene study. Three separate analyses are performed highlighting the flexibility of the approach

Ensaios cooperativos - ferrugens do trigo cone sul da América do Sul 1980-1981.

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