1,706 research outputs found
Nonlinear Hydrodynamics from Flow of Retarded Green's Function
We study the radial flow of retarded Green's function of energy-momentum
tensor and -current of dual gauge theory in presence of generic higher
derivative terms in bulk Lagrangian. These are first order non-linear Riccati
equations. We solve these flow equations analytically and obtain second order
transport coefficients of boundary plasma. This way of computing transport
coefficients has an advantage over usual Kubo approach. The non-linear equation
turns out to be a linear first order equation when we study the Green's
function perturbatively in momentum. We consider several examples including
term and generic four derivative terms in bulk. We also study the flow
equations for -charged black holes and obtain exact expressions for second
order transport coefficients for dual plasma in presence of arbitrary chemical
potentials. Finally we obtain higher derivative corrections to second order
transport coefficients of boundary theory dual to five dimensional gauge
supergravity.Comment: Version 2, reference added, typos correcte
Genetic evaluation supports differential diagnosis in adolescent patients with delayed puberty
Context: Pubertal delay can be the clinical presentation of both idiopathic hypogonadotropic hypogonadism (IHH) and self-limited delayed puberty (SLDP). Distinction between these conditions is a common but important diagnostic challenge in adolescents. Objective: To assess whether gene panel testing can assist with clinical differential diagnosis and to allow accurate and timely management of delayed puberty patients. Design: Retrospective study. Methods: Patients presenting with delayed puberty to UK Paediatric services, followed up to final diagnosis, were included. Whole-exome sequencing was analysed using a virtual panel of genes previously reported to cause either IHH or SLDP to identify rarely predicted deleterious variants. Deleterious variants were verified by in silico prediction tools. The correlation between clinical and genotype diagnosis was analysed. Results: Forty-six patients were included, 54% with a final clinical diagnosis of SLDP and 46% with IHH. Red flags signs of IHH were present in only three patients. Fifteen predicted deleterious variants in 12 genes were identified in 33% of the cohort, with most inherited in a heterozygous manner. A fair correlation between final clinical diagnosis and genotypic diagnosis was found. Panel testing was able to confirm a diagnosis of IHH in patients with pubertal delay. Genetic analysis identified three patients with IHH that had been previously diagnosed as SLDP. Conclusion: This study supports the use of targeted exome sequencing in the clinical setting to aid the differential diagnosis between IHH and SLDP in adolescents presenting with pubertal delay. Genetic evaluation thus facilitates earlier and more precise diagnosis, allowing clinicians to direct treatment appropriately
Moduli and electromagnetic black brane holography
We investigate the thermodynamic and hydrodynamic properties of 4-dimensional
gauge theories with finite electric charge density in the presence of a
constant magnetic field. Their gravity duals are planar magnetically and
electrically charged AdS black holes in theories that contain a gauge
Chern-Simons term. We present a careful analysis of the near horizon geometry
of these black branes at finite and zero temperature for the case of a scalar
field non-minimally coupled to the electromagnetic field. With the knowledge of
the near horizon data, we obtain analytic expressions for the shear viscosity
coefficient and entropy density, and also study the effect of a generic set of
four derivative interactions on their ratio. We also comment on the attractor
flows of the extremal solutions.Comment: 39 pages, no figures; v2: minor changes, refs. added; v3: typo fixed;
v4: a proof for decoupling of the viscosity mode added in appendix, matches
the published versio
Re‐defining the virtual reality dental simulator: Demonstrating concurrent validity of clinically relevant assessment and feedback
Introduction
Virtual reality (VR) dental simulators are gaining momentum as a useful tool to educate dental students. To date, no VR dental simulator exercise has been designed which is capable of reliably providing validated, meaningful clinical feedback to dental students. This study aims to measure the concurrent validity of the assessment, and the provision of qualitative feedback, pertaining to cavity preparations by VR dental simulators.
Methods
A cavity preparation exercise was created on a VR dental simulator, and assessment criteria for cavity preparations were developed. The exercise was performed 10 times in order to demonstrate a range of performances and for each, the simulator feedback was recorded. The exercises were subsequently three‐dimensionally printed and 12 clinical teachers were asked to assess the preparations according to the same criteria. Inter‐rater reliability (IRR) between clinical teachers was measured using a free‐marginal multirater kappa value. Clinical teacher assessment responses were compared with the VR simulator responses and percentage agreements calculated.
Results
IRR values for each exercise ranged from 0.39‐0.77 (69.39‐88.48%). The assessment of smoothness (κfree0.58, 78.79%) and ability to follow the outline (κfree0.56, 77.88%) demonstrated highest agreement between clinical teachers, whilst the assessment of undercut (κfree0.15, 57.58%) and depth (κfree 0.28, 64.09%) had the lowest agreement. The modal percentage agreement between clinical teachers and the VR simulator was, on average, 78% across all exercises.
Conclusion
The results of this study demonstrate that it is possible to provide reliable and clinically relevant qualitative feedback via a VR dental simulator. Further research should look to employ this technique across a broader range of exercises that help to develop other complex operative dental skills
Key features of puberty onset and progression can help distinguish self-limited delayed puberty from congenital hypogonadotrophic hypogonadism
Energy Transfer and Spectra in Simulations of Two-dimensional Compressible Turbulence
We present results of high-resolution numerical simulations of compressible
2D turbulence forced at intermediate spatial scales with a solenoidal
white-in-time external acceleration. A case with an isothermal equation of
state, low energy injection rate, and turbulent Mach number
without energy condensate is studied in detail. Analysis of energy spectra and
fluxes shows that the classical dual-cascade picture familiar from the
incompressible case is substantially modified by compressibility effects. While
the small-scale direct enstrophy cascade remains largely intact, a large-scale
energy flux loop forms with the direct acoustic energy cascade compensating for
the inverse transfer of solenoidal kinetic energy. At small scales, the direct
enstrophy and acoustic energy cascades are fully decoupled at small Mach
numbers and hence the corresponding spectral energy slopes comply with
theoretical predictions, as expected. At large scales, dispersion of acoustic
waves on vortices softens the dilatational velocity spectrum, while the
pseudo-sound component of the potential energy associated with coherent
vortices steepens the potential energy spectrum.Comment: 10 pages, 6 figures. To appear in: Turbulence in Complex Conditions,
Proc. Euromech/Ercoftac Colloquium 589, ed. M. Gorokhovski, Springer, 201
Wilsonian Approach to Fluid/Gravity Duality
The problem of gravitational fluctuations confined inside a finite cutoff at
radius outside the horizon in a general class of black hole geometries
is considered. Consistent boundary conditions at both the cutoff surface and
the horizon are found and the resulting modes analyzed. For general cutoff
the dispersion relation is shown at long wavelengths to be that of a
linearized Navier-Stokes fluid living on the cutoff surface. A cutoff-dependent
line-integral formula for the diffusion constant is derived. The
dependence on is interpreted as renormalization group (RG) flow in the
fluid. Taking the cutoff to infinity in an asymptotically AdS context, the
formula for reproduces as a special case well-known results derived
using AdS/CFT. Taking the cutoff to the horizon, the effective speed of sound
goes to infinity, the fluid becomes incompressible and the Navier-Stokes
dispersion relation becomes exact. The resulting universal formula for the
diffusion constant reproduces old results from the membrane
paradigm. Hence the old membrane paradigm results and new AdS/CFT results are
related by RG flow. RG flow-invariance of the viscosity to entropy ratio is shown to follow from the first law of thermodynamics together with
isentropy of radial evolution in classical gravity. The ratio is expected to
run when quantum gravitational corrections are included.Comment: 34 pages, harvmac, clarified boundary conditio
Prognostic significance of the expression of GFRα1, GFRα3 and Syndecan-3, Proteins binding ARTEMIN, In mammary carcinoma
10.1186/1471-2407-13-34BMC Cancer13-BCMA
Thermodynamic analysis of black hole solutions in gravitating nonlinear electrodynamics
We perform a general study of the thermodynamic properties of static
electrically charged black hole solutions of nonlinear electrodynamics
minimally coupled to gravitation in three space dimensions. The Lagrangian
densities governing the dynamics of these models in flat space are defined as
arbitrary functions of the gauge field invariants, constrained by some
requirements for physical admissibility. The exhaustive classification of these
theories in flat space, in terms of the behaviour of the Lagrangian densities
in vacuum and on the boundary of their domain of definition, defines twelve
families of admissible models. When these models are coupled to gravity, the
flat space classification leads to a complete characterization of the
associated sets of gravitating electrostatic spherically symmetric solutions by
their central and asymptotic behaviours. We focus on nine of these families,
which support asymptotically Schwarzschild-like black hole configurations, for
which the thermodynamic analysis is possible and pertinent. In this way, the
thermodynamic laws are extended to the sets of black hole solutions of these
families, for which the generic behaviours of the relevant state variables are
classified and thoroughly analyzed in terms of the aforementioned boundary
properties of the Lagrangians. Moreover, we find universal scaling laws (which
hold and are the same for all the black hole solutions of models belonging to
any of the nine families) running the thermodynamic variables with the electric
charge and the horizon radius. These scale transformations form a one-parameter
multiplicative group, leading to universal "renormalization group"-like
first-order differential equations. The beams of characteristics of these
equations generate the full set of black hole states associated to any of these
gravitating nonlinear electrodynamics...Comment: 51 single column pages, 19 postscript figures, 2 tables, GRG tex
style; minor corrections added; final version appearing in General Relativity
and Gravitatio
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