484 research outputs found

    Founding quantum theory on the basis of consciousness

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    In the present work, quantum theory is founded on the framework of consciousness, in contrast to earlier suggestions that consciousness might be understood starting from quantum theory. The notion of streams of consciousness, usually restricted to conscious beings, is extended to the notion of a Universal/Global stream of conscious flow of ordered events. The streams of conscious events which we experience constitute sub-streams of the Universal stream. Our postulated ontological character of consciousness also consists of an operator which acts on a state of potential consciousness to create or modify the likelihoods for later events to occur and become part of the Universal conscious flow. A generalized process of measurement-perception is introduced, where the operation of consciousness brings into existence, from a state of potentiality, the event in consciousness. This is mathematically represented by (a) an operator acting on the state of potential-consciousness before an actual event arises in consciousness and (b) the reflecting of the result of this operation back onto the state of potential-consciousness for comparison in order for the event to arise in consciousness. Beginning from our postulated ontology that consciousness is primary and from the most elementary conscious contents, such as perception of periodic change and motion, quantum theory follows naturally as the description of the conscious experience.Comment: 41 pages, 3 figures. To be published in Foundations of Physics, Vol 36 (6) (June 2006), published online at http://dx.doi.org/10.1007/s10701-006-9049-

    Gravitational field around a screwed superconducting cosmic string in scalar-tensor theories

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    We obtain the solution that corresponds to a screwed superconducting cosmic string (SSCS) in the framework of a general scalar-tensor theory including torsion. We investigate the metric of the SSCS in Brans-Dicke theory with torsion and analyze the case without torsion. We show that in the case with torsion the space-time background presents other properties different from that in which torsion is absent. When the spin vanish, this torsion is a ϕ\phi-gradient and then it propagates outside of the string. We investigate the effect of torsion on the gravitational force and on the geodesics of a test-particle moving around the SSCS. The accretion of matter by wakes formation when a SSCS moves with speed vv is investigated. We compare our results with those obtained for cosmic strings in the framework of scalar-tensor theory.Comment: 22 pages, LaTeX, presented at the "XXII - Encontro Nacional de Fisica de Particulas e Campos", Sao Lourenco, MG, Brazi

    Hadronic light-by-light corrections to the muon g-2: the pion-pole contribution

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    The correction to the muon anomalous magnetic moment from the pion-pole contribution to the hadronic light-by-light scattering is considered using a description of the pi0 - gamma* - gamma* transition form factor based on the large-Nc and short-distance properties of QCD. The resulting two-loop integrals are treated by first performing the angular integration analytically, using the method of Gegenbauer polynomials, followed by a numerical evaluation of the remaining two-dimensional integration over the moduli of the Euclidean loop momenta. The value obtained, a_{mu}(LbyL;pi0) = +5.8 (1.0) x 10^{-10}, disagrees with other recent calculations. In the case of the vector meson dominance form factor, the result obtained by following the same procedure reads a_{mu}(LbyL;pi0)_{VMD} = +5.6 x 10^{-10}, and differs only by its overall sign from the value obtained by previous authors. Inclusion of the eta and eta-prime poles gives a total value a_{mu}(LbyL;PS) = +8.3 (1.2) x 10^{-10} for the three pseudoscalar states. This result substantially reduces the difference between the experimental value of a_{mu} and its theoretical counterpart in the standard model.Comment: 27 pages, Latex, 3 figures. v2: version to be published in Phys. Rev. D, Note added and references updated (don't worry, sign has not changed

    Contribution of Cystine-Glutamate Antiporters to the Psychotomimetic Effects of Phencyclidine

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    Altered glutamate signaling contributes to a myriad of neural disorders, including schizophrenia. While synaptic levels are intensely studied, nonvesicular release mechanisms, including cystine–glutamate exchange, maintain high steady-state glutamate levels in the extrasynaptic space. The existence of extrasynaptic receptors, including metabotropic group II glutamate receptors (mGluR), pose nonvesicular release mechanisms as unrecognized targets capable of contributing to pathological glutamate signaling. We tested the hypothesis that activation of cystine–glutamate antiporters using the cysteine prodrug N-acetylcysteine would blunt psychotomimetic effects in the rodent phencyclidine (PCP) model of schizophrenia. First, we demonstrate that PCP elevates extracellular glutamate in the prefrontal cortex, an effect that is blocked by N-acetylcysteine pretreatment. To determine the relevance of the above finding, we assessed social interaction and found that N-acetylcysteine reverses social withdrawal produced by repeated PCP. In a separate paradigm, acute PCP resulted in working memory deficits assessed using a discrete trial t-maze task, and this effect was also reversed by N-acetylcysteine pretreatment. The capacity of N-acetylcysteine to restore working memory was blocked by infusion of the cystine–glutamate antiporter inhibitor (S)-4-carboxyphenylglycine into the prefrontal cortex or systemic administration of the group II mGluR antagonist LY341495 indicating that the effects of N-acetylcysteine requires cystine–glutamate exchange and group II mGluR activation. Finally, protein levels from postmortem tissue obtained from schizophrenic patients revealed significant changes in the level of xCT, the active subunit for cystine–glutamate exchange, in the dorsolateral prefrontal cortex. These data advance cystine–glutamate antiporters as novel targets capable of reversing the psychotomimetic effects of PCP

    Risk-shifting Through Issuer Liability and Corporate Monitoring

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    This article explores how issuer liability re-allocates fraud risk and how risk allocation may reduce the incidence of fraud. In the US, the apparent absence of individual liability of officeholders and insufficient monitoring by insurers under-mine the potential deterrent effect of securities litigation. The underlying reasons why both mechanisms remain ineffective are collective action problems under the prevailing dispersed ownership structure, which eliminates the incentives to moni-tor set by issuer liability. This article suggests that issuer liability could potentially have a stronger deterrent effect when it shifts risk to individuals or entities holding a larger financial stake. Thus, it would enlist large shareholders in monitoring in much of Europe. The same risk-shifting effect also has implications for the debate about the relationship between securities litigation and creditor interests. Credi-tors’ claims should not be given precedence over claims of defrauded investors (e.g., because of the capital maintenance principle), since bearing some of the fraud risk will more strongly incentivise large creditors, such as banks, to monitor the firm in jurisdictions where corporate debt is relatively concentrated

    Coherent coupling between radio frequency, optical, and acoustic waves in piezo-optomechanical circuits

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    The interaction of optical and mechanical modes in nanoscale optomechanical systems has been widely studied for applications ranging from sensing to quantum information science. Here, we develop a platform for cavity optomechanical circuits in which localized and interacting 1550 nm photons and 2.4 GHz phonons are combined with photonic and phononic waveguides. Working in GaAs facilitates manipulation of the localized mechanical mode either with a radio frequency field through the piezo-electric effect, or optically through the strong photoelastic effect. We use this to demonstrate a novel acoustic wave interference effect, analogous to coherent population trapping in atomic systems, in which the coherent mechanical motion induced by the electrical drive can be completely cancelled out by the optically-driven motion. The ability to manipulate cavity optomechanical systems with equal facility through either photonic or phononic channels enables new device and system architectures for signal transduction between the optical, electrical, and mechanical domains

    The incorporation of14C‐glycerol into different species of diglycerides and triglycerides in rat liver slices

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    The relative rates of de novo synthesis of species of diglycerides and triglycerides from14C‐glycerol were examined in rat liver slices. Diglycerides containing one or two double bonds per molecule and triglycerides containing four or more double bonds per molecule represented 70% and 60% respectively of the newly synthesized diglycerides and triglycerides. The newly synthesized triglycerides were more unsaturated than the endogenous triglycerides. Our results suggest that a nonrandom synthesis of species of diglycerides occurred followed by an almost random utilization of the various diglyceride species for the biosynthesis of triglycerides.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142207/1/lipd0411.pd

    Regularity Properties and Pathologies of Position-Space Renormalization-Group Transformations

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    We reconsider the conceptual foundations of the renormalization-group (RG) formalism, and prove some rigorous theorems on the regularity properties and possible pathologies of the RG map. Regarding regularity, we show that the RG map, defined on a suitable space of interactions (= formal Hamiltonians), is always single-valued and Lipschitz continuous on its domain of definition. This rules out a recently proposed scenario for the RG description of first-order phase transitions. On the pathological side, we make rigorous some arguments of Griffiths, Pearce and Israel, and prove in several cases that the renormalized measure is not a Gibbs measure for any reasonable interaction. This means that the RG map is ill-defined, and that the conventional RG description of first-order phase transitions is not universally valid. For decimation or Kadanoff transformations applied to the Ising model in dimension d3d \ge 3, these pathologies occur in a full neighborhood {β>β0,h<ϵ(β)}\{ \beta > \beta_0 ,\, |h| < \epsilon(\beta) \} of the low-temperature part of the first-order phase-transition surface. For block-averaging transformations applied to the Ising model in dimension d2d \ge 2, the pathologies occur at low temperatures for arbitrary magnetic-field strength. Pathologies may also occur in the critical region for Ising models in dimension d4d \ge 4. We discuss in detail the distinction between Gibbsian and non-Gibbsian measures, and give a rather complete catalogue of the known examples. Finally, we discuss the heuristic and numerical evidence on RG pathologies in the light of our rigorous theorems.Comment: 273 pages including 14 figures, Postscript, See also ftp.scri.fsu.edu:hep-lat/papers/9210/9210032.ps.

    First radial velocity results from the MINiature Exoplanet Radial Velocity Array (MINERVA)

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    The MINiature Exoplanet Radial Velocity Array (MINERVA) is a dedicated observatory of four 0.7m robotic telescopes fiber-fed to a KiwiSpec spectrograph. The MINERVA mission is to discover super-Earths in the habitable zones of nearby stars. This can be accomplished with MINERVA's unique combination of high precision and high cadence over long time periods. In this work, we detail changes to the MINERVA facility that have occurred since our previous paper. We then describe MINERVA's robotic control software, the process by which we perform 1D spectral extraction, and our forward modeling Doppler pipeline. In the process of improving our forward modeling procedure, we found that our spectrograph's intrinsic instrumental profile is stable for at least nine months. Because of that, we characterized our instrumental profile with a time-independent, cubic spline function based on the profile in the cross dispersion direction, with which we achieved a radial velocity precision similar to using a conventional "sum-of-Gaussians" instrumental profile: 1.8 m s1^{-1} over 1.5 months on the RV standard star HD 122064. Therefore, we conclude that the instrumental profile need not be perfectly accurate as long as it is stable. In addition, we observed 51 Peg and our results are consistent with the literature, confirming our spectrograph and Doppler pipeline are producing accurate and precise radial velocities.Comment: 22 pages, 9 figures, submitted to PASP, Peer-Reviewed and Accepte

    The presence of a systemic inflammatory response predicts poorer survival in patients receiving adjuvant 5-FU chemotherapy following potentially curative resection for colorectal cancer

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    There is increasing evidence that the presence of a systemic inflammatory response plays an important role in survival following curative resection for colorectal cancer. The present study evaluated the relationship between C-reactive protein concentrations and survival in a cohort of patients receiving adjuvant 5-fluorouracil (5-FU) chemotherapy following potentially curative resection for colorectal cancer. In all, 222 patients undergoing potentially curative resection for colorectal cancer were studied. Of these, 50 patients received adjuvant 5-FU-based chemotherapy. Circulating concentrations of C-reactive protein were measured prior to surgery. The minimum follow-up was 15 months; the median follow-up of the survivors was 38 months. During this period 61 patients died, 32 patients of their cancer and 29 of intercurrent disease. In those patients who did not receive adjuvant chemotherapy, age (P<0.001), Dukes stage (P<0.05) and an elevated C-reactive protein (P<0.01) were significantly associated with survival. In those patients who did receive adjuvant chemotherapy, an elevated C-reactive protein concentration (P<0.01) was significantly associated with survival. The presence of a systemic inflammatory response is an independent predictor of poor outcome in patients receiving adjuvant 5-FU-based chemotherapy following potentially curative resection for colorectal cancer
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