Multiracial versus Collective Black Categories

Current census debates in Brazil surrounding Brazilian race categories center on two contrasting proposals: the adoption of the multiracial moreno term vs. the use of the collective black classification negro. Those proposing the former base their argument on the right to self-classify according to one’s own sense of identity. Proponents of the negro category contend that it would be most efficient for redressing racial discrimination. We examine the meaning and saliency of these categories and explore the possible consequences of their adoption. Using national survey data, we demonstrate how education, age, color, sex and local racial composition structure the choices of moreno and negro over official census terms. Findings include a negative correlation between education and the choice of moreno, while the opposite is true for negro. In addition, an age effect on both categories suggests a popular shift in racial labeling away from official census terms. We note that similar issues structure current census debates in the USA

Shifting racial dubjectivities and Ideologies in Brazil

Census ethnoracial categories often reflect national ideologies and attendant subjectivities. Nonetheless, Brazilians frequently prefer the non-census terms moreno (brown) and negro (black), and both are core to antithetical ideologies: racial ambiguity versus racial affirmation. Their use may be in flux as Brazil recently adopted unprecedented race-targeted public policy. We examine propensities to self-classify as moreno and negro before and after the policy shift. Using regression modeling on national survey data from 1995 and 2008 that captured self-classification in open and closed formats, we find moreno is highly salient but increasingly constricted, while negro is restricted in use, though increasingly popular. Negro’s growth is mostly confined to the darker pole of Brazil’s color continuum. Education correlates in opposing directions: negative with moreno and positive with negro. Our findings proxy broad ideological shift from racial ambiguity to negro racial affirmation. They suggest race-targeted policy is transforming racial subjectivities and ideologies in Brazil

Interrogating race: color, racial categories, and class across the Americas

We address long-standing debates on the utility of racial categories and color scales for understanding inequality in the United States and Latin America, using novel data that enable comparisons of these measures across both broad regions. In particular, we attend to the degree to which color and racial category inequality operate independently of parental socioeconomic status. We find a variety of patterns of racial category and color inequality, but that in most countries accounting for maternal education changes our coefficients by 5% or less. Overall, we argue that several posited divergences in ethnoracial stratification processes in the United States, compared with Latin America, might be overstated. We conclude that the comparison of the effects of multiple ethnoracial markers, such as color and racial categories, for the analysis of social stratification holds substantial promise for untangling the complexities of “race” across the Americas

Does race response shift impact racial inequality?

Background: Previous research posits that racial reclassification, or response shift, may confound measures of racial earnings inequality. However, this claim has not been systematically tested. Objective: We measure racial response shift in Brazil and examine its impact on white-to-nonwhite earnings inequality between survey waves over ten years at nine-month intervals. Methods: We use individual-level linked data from the 2002-2012 Monthly Employment Survey, involving Brazil's six largest metropolitan areas (n = 400,046). We describe the level and pattern of racial reclassification across time and by income rank. We then decompose racial inequality into two components (income and population ratios) to examine the impact of racial response shift on estimates of racial inequality and to construct analytic counterfactuals. Results: Results reveal that 16Š of our sample shifted their racial responses between survey waves. Nonetheless, we show that this level of response shift had no substantial impact on estimates of income inequality. We explain the counterintuitive results by demonstrating how bidirectional racial classification flows - lightening and darkening - countervail each other due to their similar income profiles and racial reclassification rates. Contribution: We offer a first empirical analysis of how racial response shift impacts estimates of racial earnings inequality using individual-level linked data from a large-sample survey

Racial and ethnic inequality in Latin America

This chapter examines socioeconomic inequality in Latin America through the lens of race and ethnicity. We primarily use national census data from the International Public Use Micro Data Sample (IPUMS). Since censuses use inconsistent measures of race and ethnicity, we also draw on two additional measures from the Latin American Public Opinion Project (LAPOP). Unlike censuses, LAPOP data offer a more consistent ethnoracial scheme across countries and a unique interviewer-rated skin color measure. Our study shows that black and indigenous populations and those with darker skin color experience educational, income, and occupational disadvantages, even after controlling for their social origins. However, inequality and hierarchical ordering of Afro-descendants, indigenous peoples, mestizos, whites, and others vary across countries. We include an extended examination of educational inequality in Brazil, the region’s largest country. The chapter concludes with an exploration of public policy approaches to address black and indigenous disadvantage across Latin America while also highlighting the case of Brazil, where targeted antiracism policy is most advanced

Design and development of a multibeam 1.4 GHz pushbroom microwave radiometer

The design and operation of a multiple beam, digital signal processing radiometer are discussed. The discussion includes a brief description of each major subsystem and an overall explanation of the hardware requirements and operation. A series of flight tests was conducted in which sea-truth sites, as well as an existing radiometer were used to verify the Pushbroom Radiometer performance. The results of these tests indicate that the Pushbroom Radiometer did meet the sensitivity design goal of 1.0 kelvin, and exceeded the accuracy requirement of 2.0 kelvin. Additional performance characteristics and test results are also presented

Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug

Current drug eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug delivery. A novel, absorbable-coating sirolimus-eluting stent (AC-SES) was evaluated for its capacity to deliver drug more evenly within the intimal area rather than concentrating drug around the stent struts and for its ability to match coating erosion with drug release. The coating consisted of absorbable poly-lactide-co-glycolic acid (PLGA) and crystalline sirolimus deposited by a dry-powder electrostatic process. The AC-SES demonstrated enhanced drug stability under simulated use conditions and consistent drug delivery balanced with coating erosion in a porcine coronary implant model. The initial drug burst was eliminated and drug release was sustained after implantation. The coating was absorbed within 90 days. Following implantation into porcine coronary arteries the AC-SES coating is distributed in the surrounding intimal tissue over the course of several weeks. Computational modeling of drug delivery characteristics demonstrates how distributed coating optimizes the load of drug immediately around each stent strut and extends drug delivery between stent struts. The result was a highly efficient arterial uptake of drug with superior performance to a clinical bare metal stent (BMS). Neointimal thickness (0.17 ± 0.07 mm vs. 0.28 ± 0.11 mm) and area percent stenosis (22 ± 9% vs. 35 ± 12%) were significantly reduced (p < 0.05) by the AC-SES compared to the BMS 30 days after stent implantation in an overlap configuration in porcine coronary arteries. Inflammation was significantly reduced in the AC-SES compared to the BMS at both 30 and 90 days after implantation. Biocompatible, rapidly absorbable stent coatings enable the matching of drug release with coating erosion and provide for the controlled migration of coating material into tissue to reduce vicissitudes in drug tissue levels, optimizing efficacy and reducing potential toxicity.Micell Technologies, Inc.National Institutes of Health (U.S.) (R01 GM49039

A prophylactic vaccine for breast cancer?

Cancer vaccines are the Holy Grail for patients and clinicians alike. The possibility that we can be vaccinated against common cancers is very appealing and the socioeconomic consequences are significant. A recent paper from Vincent Tuohy's group, published in the journal Nature Medicine, suggests a new approach for the development of a prophylactic vaccine for breast cancer. Their strategy was to induce mammary gland failure in mice by immunisation with an antibody specific to a milk protein that resulted in autoimmunity during lactation. This also showed some efficacy as a therapeutic vaccine. Can we look forward to the elimination of breast cancer

ChIP-PaM: an algorithm to identify protein-DNA interaction using ChIP-Seq data

<p>Abstract</p> <p>Background</p> <p>ChIP-Seq is a powerful tool for identifying the interaction between genomic regulators and their bound DNAs, especially for locating transcription factor binding sites. However, high cost and high rate of false discovery of transcription factor binding sites identified from ChIP-Seq data significantly limit its application.</p> <p>Results</p> <p>Here we report a new algorithm, ChIP-PaM, for identifying transcription factor target regions in ChIP-Seq datasets. This algorithm makes full use of a protein-DNA binding pattern by capitalizing on three lines of evidence: 1) the tag count modelling at the peak position, 2) pattern matching of a specific tag count distribution, and 3) motif searching along the genome. A novel data-based two-step eFDR procedure is proposed to integrate the three lines of evidence to determine significantly enriched regions. Our algorithm requires no technical controls and efficiently discriminates falsely enriched regions from regions enriched by true transcription factor (TF) binding on the basis of ChIP-Seq data only. An analysis of real genomic data is presented to demonstrate our method.</p> <p>Conclusions</p> <p>In a comparison with other existing methods, we found that our algorithm provides more accurate binding site discovery while maintaining comparable statistical power.</p

Equine Arteritis Virus Has Specific Tropism for Stromal Cells and CD8\u3csup\u3e+\u3c/sup\u3e T and CD21\u3csup\u3e+\u3c/sup\u3e B Lymphocytes but Not for Glandular Epithelium at the Primary Site of Persistent Infection in the Stallion Reproductive Tract

Equine arteritis virus (EAV) has a global impact on the equine industry as the causative agent of equine viral arteritis (EVA), a respiratory, systemic, and reproductive disease of equids. A distinctive feature of EAV infection is that it establishes long-term persistent infection in 10 to 70% of infected stallions (carriers). In these stallions, EAV is detectable only in the reproductive tract, and viral persistence occurs despite the presence of high serum neutralizing antibody titers. Carrier stallions constitute the natural reservoir of the virus as they continuously shed EAV in their semen. Although the accessory sex glands have been implicated as the primary sites of EAV persistence, the viral host cell tropism and whether viral replication in carrier stallions occurs in the presence or absence of host inflammatory responses remain unknown. In this study, dual immunohistochemical and immunofluorescence techniques were employed to unequivocally demonstrate that the ampulla is the main EAV tissue reservoir rather than immunologically privileged tissues (i.e., testes). Furthermore, we demonstrate that EAV has specific tropism for stromal cells (fibrocytes and possibly tissue macrophages) and CD8+ T and CD21+ B lymphocytes but not glandular epithelium. Persistent EAV infection is associated with moderate, multifocal lymphoplasmacytic ampullitis comprising clusters of B (CD21+) lymphocytes and significant infiltration of T (CD3+, CD4+, CD8+, and CD25+) lymphocytes, tissue macrophages, and dendritic cells (Iba-1+ and CD83+), with a small number of tissue macrophages expressing CD163 and CD204 scavenger receptors. This study suggests that EAV employs complex immune evasion mechanisms that warrant further investigation