Winter residency and site association in the critically endangered North East Atlantic spurdog (Squalus acanthias)

Identification and incorporation of residential behaviour into elasmobranch management plans has the potential to substantially increase their effectiveness by identifying sites where Marine Protected Areas (MPAs) might be used to help conserve species with high migratory potential. There is evidence that spurdog (Squalus acanthias) displays site association in some parts of its global distribution, but this has currently not been shown within the North East Atlantic where it is critically endangered. Here we investigate the movements of electronically tagged spurdog within Loch Etive, a sea loch on the west coast of Scotland. Archival data storage tags (DSTs), that recorded depth and temperature, revealed that mature female spurdog over wintered within the loch, restricting their movements to the upper basin, and remaining either in the loch or the local vicinity for the rest of the year. This finding was supported by evidence for limited movements from conventional mark/recapture data and acoustically tagged individual spurdog. Some of the movements between the loch basins appear to be associated with breeding and parturition events. This high level of site association suggests that spatial protection of the loch would aid the conservation of different age and sex classes of spurdog

Effects of Letter Transposition in Subliminal Primes on Perceived Content of Abstract Images

Subliminal presentation of a stimulus can influence responses to later stimuli. This effect is known as priming. The current study used Microsoft PowerPoint as a novel, low-cost paradigm to present experimental stimuli. Thirty-one undergraduate participants viewed a PowerPoint presentation that contained conditions with no, with unscrambled, and with center-scrambled sexually-themed messages. The effects of gender, counterbalancing, and type of message on perceived sexual content in experimenter-made inkblots was assessed. The current study failed to find any significant differences or interaction effects between any of the variables. A post-hoc analysis revealed a significant priming effect. Possible confounding variables and suggestions for future research are discussed

Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor:implications for adrenomedullin and calcitonin gene-related peptide pharmacology

Background and Purpose Receptor activity-modifying proteins (RAMPs) define the pharmacology of the calcitonin receptor-like receptor (CLR). The interactions of the different RAMPs with this class B GPCR yield high-affinity calcitonin gene-related peptide (CGRP) or adrenomedullin (AM) receptors. However, the mechanism for this is unclear. Experimental Approach Guided by receptor models, we mutated residues in the N-terminal helix of CLR, RAMP2 and RAMP3 hypothesized to be involved in peptide interactions. These were assayed for cAMP production with AM, AM2 and CGRP together with their cell surface expression. Binding studies were also conducted for selected mutants. Key Results An important domain for peptide interactions on CLR from I32 to I52 was defined. Although I41 was universally important for binding and receptor function, the role of other residues depended on both ligand and RAMP. Peptide binding to CLR/RAMP3 involved a more restricted range of residues than that to CLR/RAMP1 or CLR/RAMP2. E101 of RAMP2 had a major role in AM interactions, and F111/W84 of RAMP2/3 was important with each peptide. Conclusions and Implications RAMP-dependent effects of CLR mutations suggest that the different RAMPs control accessibility of peptides to binding residues situated on the CLR N-terminus. RAMP3 appears to alter the role of specific residues at the CLR-RAMP interface compared with RAMP1 and RAMP2

Magnetic-interference patterns in Josephson junctions with d+is symmetry

The magnetic interference pattern and the spontaneous flux in unconventional Josephson junctions of superconductors with d+is symmetry are calculated for different reduced junction lengths and the relative factor of the d and s wave components. This is a time reversal broken symmetry state. We study the stability of the fractional vortex and antivortex which are spontaneously formed and examine their evolution as we change the length and the relative factor of d and s wave components. The asymmetry in the field modulated diffraction pattern exists for lengths as long as L=10\lambda_J.Comment: 8 pages, 6 eps files, submitted to PR

Critical currents in Josephson junctions, with unconventional pairing symmetry: dx2−y2+isd_{x^2-y^2}+is versus dx2−y2+idxyd_{x^2-y^2}+id_{xy}

Phenomenological Ginzburg-Landau theory is used to calculate the possible spontaneous vortex states that may exist at corner junctions of $d_{x^2-y^2}+ix$-wave, (where $x=s$ or $x=d_{xy}$) and s-wave superconductors. We study the magnetic flux and the critical current modulation with the junction orientation angle $\theta$, the magnitude of the order parameter, and the magnetic field $H$. It is seen that the critical current $I_c$ versus the magnetic flux $\Phi$ relation is symmetric / asymmetric for $x=d_{xy}/s$ when the orientation is exactly such that the lobes of the dominant $d_{x^2-y^2}$-wave order parameter points towards the two junctions, which are at right angles for the corner junction. The conclusion is that a measurement of the $I_c(\Phi)$ relation may distinguish which symmetry ($d_{x^2-y^2}+is$ or $d_{x^2-y^2}+id_{xy}$) the order parameter has.Comment: 11 pages with 11 figures, Changed conten

Associated Production of a Z Boson and a Single Heavy-Quark Jet

The leading-order process for the production of a Z boson and a heavy-quark jet at hadron colliders is gQ -> ZQ (Q=c,b). We calculate this cross section at next-to-leading order at the Tevatron and the LHC, and compare it with other sources of ZQ events. This process is a background to new physics, and can be used to measure the heavy-quark distribution function.Comment: 15 pages, 9 figures. Version to appear in Phys. Rev.

Distinctive Kaposi Sarcoma-Associated Herpesvirus Serological Profile during Acute Plasmodium falciparum Malaria Episodes

The seroprevalence of Kaposi sarcoma-associated herpesvirus (KSHV) and the incidence of endemic Kaposi sarcoma (KS) overlap with regions of malaria endemicity in sub-Saharan Africa. Multiple studies have shown an increased risk of KSHV seroconversion in children from high malaria compared to low malaria regions; however, the impact of acute episodes of Plasmodium falciparum (P. falciparum) malaria on KSHV’s biphasic life cycle and lytic reactivation has not been determined. Here, we examined KSHV serological profiles and viral loads in 134 children with acute malaria and 221 healthy children from high malaria regions in Kisumu, as well as 77 healthy children from low malaria regions in Nandi. We assayed KSHV, Epstein–Barr virus (EBV), and P. falciparum malaria antibody responses in these three by multiplexed Luminex assay. We confirmed that KSHV seroprevalence was significantly associated with malaria endemicity (OR = 1.95, 1.18–3.24 95% CI, p = 0.01) with 71–77% seropositivity in high-malaria (Kisumu) compared to 28% in low-malaria (Nandi) regions. Furthermore, KSHV serological profiles during acute malaria episodes were distinct from age-matched non-malaria-infected children from the same region. Paired IgG levels also varied after malaria treatment, with significantly higher anti-ORF59 at day 0 but elevated ORF38, ORF73, and K8.1 at day 3. Acute malaria episodes is characterized by perturbation of KSHV latency in seropositive children, providing further evidence that malaria endemicity contributes to the observed increase in endemic KS incidence in sub-Saharan Africa

Spin-gravity coupling and gravity-induced quantum phases

External gravitational fields induce phase factors in the wave functions of particles. The phases are exact to first order in the background gravitational field, are manifestly covariant and gauge invariant and provide a useful tool for the study of spin-gravity coupling and of the optics of particles in gravitational or inertial fields. We discuss the role that spin-gravity coupling plays in particular problems.Comment: 18 pages, 1 figur

News from the Muon (g-2) Experiment at BNL

The magnetic moment anomaly a_mu = (g_mu - 2) / 2 of the positive muon has been measured at the Brookhaven Alternating Gradient Synchrotron with an uncertainty of 0.7 ppm. The new result, based on data taken in 2000, agrees well with previous measurements. Standard Model evaluations currently differ from the experimental result by 1.6 to 3.0 standard deviations.Comment: Talk presented at RADCOR - Loops and Legs 2002, Kloster Banz, Germany, September 8-13 2002, to be published in Nuclear Physics B (Proc. Suppl.); 5 pages, 3 figure

Effective interaction between helical bio-molecules

The effective interaction between two parallel strands of helical bio-molecules, such as deoxyribose nucleic acids (DNA), is calculated using computer simulations of the "primitive" model of electrolytes. In particular we study a simple model for B-DNA incorporating explicitly its charge pattern as a double-helix structure. The effective force and the effective torque exerted onto the molecules depend on the central distance and on the relative orientation. The contributions of nonlinear screening by monovalent counterions to these forces and torques are analyzed and calculated for different salt concentrations. As a result, we find that the sign of the force depends sensitively on the relative orientation. For intermolecular distances smaller than $6\AA$ it can be both attractive and repulsive. Furthermore we report a nonmonotonic behaviour of the effective force for increasing salt concentration. Both features cannot be described within linear screening theories. For large distances, on the other hand, the results agree with linear screening theories provided the charge of the bio-molecules is suitably renormalized.Comment: 18 pages, 18 figures included in text, 100 bibliog