12 research outputs found
Acute parkinsonism due to transdermal methanol intoxication: First report = Akut parkinsonizmus transdermalis metanolmérgezés következtében: Első beszámoló
Introduction – Methanol is a colorless
and highly toxic liquid similar to ethanol in
odor and taste. Methanol intake can lead
to severe metabolic acidosis, loss of vision,
permanent neurological damage, and death.
Case report – We report a case of a
19-year-old female patient who had no
known disease history. A large portion of
her back was covered in spirits for back pain
and kept on for 2 days. Cranial magnetic
resonance imaging (MRI) on the 5th day
showed hyperintense pathologic signal
changes in the T2 sequence without contrast
enhancement in the bilateral frontal cortical-
subcortical regions and basal ganglia.
Following neurological examination of the
patient, she was found to have bradymimia,
marked resting tremor, bradykinesia, and
dystonia on the right upper and lower
extremities. Our case is important because
it is the only case where parkinsonism
developed as a result of acute transdermal
methanol intoxication. | Bevezetés – A metanol színtelen és erősen
mérgező folyadék, ami szagában és ízében
az etanolhoz hasonló. A metanol bevitele
súlyos metabolikus acidózishoz, látásvesztés-
hez, maradandó neurológiai károsodáshoz
és halálhoz vezethet.
Esetismertetés – Egy 19 éves nőbeteg ese-
téről számolunk be, akinek anamnézisében
nem szerepelt semmilyen betegség. A hátának
nagy részét hátfájás miatt alkohollal borítot-
ták be, amit 2 napig rajtatartottak. A koponya
mágneses rezonanciás képalkotása (MRI) az 5.
napon a T2 szekvenciában kontrasztfokozódás
nélküli hiperintenzív kóros jelváltozást mutatott
a kétoldali frontális corticalis-subcorticalis
régiókban és a bazális ganglionokban. A beteg
neurológiai vizsgálatát követően a jobb felső
és alsó végtagokon bradymimia, kifejezett
nyugalmi tremor, bradykinesia és dystonia
volt kimutatható. Esetünk azért fontos, mert
ez az egyetlen olyan beszámoló, ami akut
transdermalis metanolmérgezés következté-
ben kialakult parkinsonizmust ismertet
Cardiac Safety of Donepezil in Elderly Patients with Alzheimer Disease
Objective Donepezil is a widely used cholinesterase inhibitor for the treatment of Alzheimer's disease (AD), however its cholinergic adverse side effects on the cardiovascular system are still unclear. In this study, we aimed to examine the adverse side effects caused by donepezil on cardiac rhythm and postural blood pressure changes in elderly patients with Alzheimer Disease
Investigation of the Effects of Polypharmacy on Cognitive Functions: Cohort Study
Background: Alzheimer's Disease (AD) is a major concern in growing chronic diseases in the geriatric society and its connection with polypharmacy has not been sufficiently understood. Aim: This Study investigate the association between Alzheimer's disease and polypharmacy. Methods: A prospective cohort study. Patients with diagnosis of the AD and being older than 55 included in study between March 2017 and September 2017 who applied at the Bezmialem Vakif University Hospital, Istanbul. According to number of used medicine participant divided 3 groups. Age, sex, weight, height were recorded as Socio-demographic variables, a physical and cognitive examination was also performed to determine Mini-Mental State Exam (MMSE) and Katz-Activities of Daily Living (KATZ-ADL) scores. Deterioration of cognitive functions has been associated with alteration of MMSE between 6 months among the groups. Results: We included 79 AD patients and >55 years old into study. Reduction of MMSE scores between six month period were, 1.0 point decrease (p= 0.034), 1.29 points decrease (p= 0.003) and 2.05 points decrease (p= 0.001) respectively. There is statistically significant difference between group I to III, KATZ- ADL (p= 0.07). Conclusion: In our study the largest decline in cognitive function seen in group with the highest number of medicine used. Cognitive functions has declined in three groups after 6 months but this cannot be directly linked with polypharmacy. Cognitive and functional status has affected from multiple drug use. There is a need for more detailed and bigger clinical studies about the relationship between polypharmacy and AD
Validity and Reliability Studies of Modified Mini Mental State Examination (MMSE-E) For Turkish Illiterate Patients With Diagnosis of Alzheimer Disease
Vitamin B12 and folic acid levels are not related to length of stay in elderly inpatients
Objective: We designed this study, to evaluate the interaction (relation) between vitamin B12 and folic acid levels and length of hospital stay in elderly inpatients
Can sitagliptin a GLP-1 inhibitor, improve cognitive function in elderly diabetic patients with Alzheimer s disease
A rare dementing disease: Adult neuronal ceroid lipofuscinoses
To emphasize the importance of clinical and ultrastructural findings for diagnosing adult neuronal ceroid lipofuscinosis (ANCL), the authors retrospectively reviewed six patients with biopsyproven ANCL. In all cases, ophthalmologic examinations were normal, and electron microscopic studies demonstrated characteristic granular osmiophilic deposits within the eccrine epithelial cells. The inheritance and mechanism of ANCL remain unknown, and the diagnosis is based on clinical features and ultrastructural examination of the cerebral tissue or extracerebral accumulation of lipopigments. This study suggests that ANCL should be considered as a possible diagnosis in patients with early-onset dementia. © 2012 American Psychiatric Association