Acute parkinsonism due to transdermal methanol intoxication: First report = Akut parkinsonizmus transdermalis metanolmérgezés következtében: Első beszámoló

Introduction – Methanol is a colorless and highly toxic liquid similar to ethanol in odor and taste. Methanol intake can lead to severe metabolic acidosis, loss of vision, permanent neurological damage, and death. Case report – We report a case of a 19-year-old female patient who had no known disease history. A large portion of her back was covered in spirits for back pain and kept on for 2 days. Cranial magnetic resonance imaging (MRI) on the 5th day showed hyperintense pathologic signal changes in the T2 sequence without contrast enhancement in the bilateral frontal cortical- subcortical regions and basal ganglia. Following neurological examination of the patient, she was found to have bradymimia, marked resting tremor, bradykinesia, and dystonia on the right upper and lower extremities. Our case is important because it is the only case where parkinsonism developed as a result of acute transdermal methanol intoxication. | Bevezetés – A metanol színtelen és erősen mérgező folyadék, ami szagában és ízében az etanolhoz hasonló. A metanol bevitele súlyos metabolikus acidózishoz, látásvesztés- hez, maradandó neurológiai károsodáshoz és halálhoz vezethet. Esetismertetés – Egy 19 éves nőbeteg ese- téről számolunk be, akinek anamnézisében nem szerepelt semmilyen betegség. A hátának nagy részét hátfájás miatt alkohollal borítot- ták be, amit 2 napig rajtatartottak. A koponya mágneses rezonanciás képalkotása (MRI) az 5. napon a T2 szekvenciában kontrasztfokozódás nélküli hiperintenzív kóros jelváltozást mutatott a kétoldali frontális corticalis-subcorticalis régiókban és a bazális ganglionokban. A beteg neurológiai vizsgálatát követően a jobb felső és alsó végtagokon bradymimia, kifejezett nyugalmi tremor, bradykinesia és dystonia volt kimutatható. Esetünk azért fontos, mert ez az egyetlen olyan beszámoló, ami akut transdermalis metanolmérgezés következté- ben kialakult parkinsonizmust ismertet

Cardiac Safety of Donepezil in Elderly Patients with Alzheimer Disease

Objective Donepezil is a widely used cholinesterase inhibitor for the treatment of Alzheimer's disease (AD), however its cholinergic adverse side effects on the cardiovascular system are still unclear. In this study, we aimed to examine the adverse side effects caused by donepezil on cardiac rhythm and postural blood pressure changes in elderly patients with Alzheimer Disease

Investigation of the Effects of Polypharmacy on Cognitive Functions: Cohort Study

Background: Alzheimer's Disease (AD) is a major concern in growing chronic diseases in the geriatric society and its connection with polypharmacy has not been sufficiently understood. Aim: This Study investigate the association between Alzheimer's disease and polypharmacy. Methods: A prospective cohort study. Patients with diagnosis of the AD and being older than 55 included in study between March 2017 and September 2017 who applied at the Bezmialem Vakif University Hospital, Istanbul. According to number of used medicine participant divided 3 groups. Age, sex, weight, height were recorded as Socio-demographic variables, a physical and cognitive examination was also performed to determine Mini-Mental State Exam (MMSE) and Katz-Activities of Daily Living (KATZ-ADL) scores. Deterioration of cognitive functions has been associated with alteration of MMSE between 6 months among the groups. Results: We included 79 AD patients and >55 years old into study. Reduction of MMSE scores between six month period were, 1.0 point decrease (p= 0.034), 1.29 points decrease (p= 0.003) and 2.05 points decrease (p= 0.001) respectively. There is statistically significant difference between group I to III, KATZ- ADL (p= 0.07). Conclusion: In our study the largest decline in cognitive function seen in group with the highest number of medicine used. Cognitive functions has declined in three groups after 6 months but this cannot be directly linked with polypharmacy. Cognitive and functional status has affected from multiple drug use. There is a need for more detailed and bigger clinical studies about the relationship between polypharmacy and AD

Vitamin B12 and folic acid levels are not related to length of stay in elderly inpatients

Objective: We designed this study, to evaluate the interaction (relation) between vitamin B12 and folic acid levels and length of hospital stay in elderly inpatients

A rare dementing disease: Adult neuronal ceroid lipofuscinoses

To emphasize the importance of clinical and ultrastructural findings for diagnosing adult neuronal ceroid lipofuscinosis (ANCL), the authors retrospectively reviewed six patients with biopsyproven ANCL. In all cases, ophthalmologic examinations were normal, and electron microscopic studies demonstrated characteristic granular osmiophilic deposits within the eccrine epithelial cells. The inheritance and mechanism of ANCL remain unknown, and the diagnosis is based on clinical features and ultrastructural examination of the cerebral tissue or extracerebral accumulation of lipopigments. This study suggests that ANCL should be considered as a possible diagnosis in patients with early-onset dementia. © 2012 American Psychiatric Association