La Bourse Régionale des Valeurs Mobilières en Afrique de lÓuest:líntroduction en bourse

La présente recherche est une des premières sur la BRVM par conséquent dans l’océan des connaissances elle correspond à une épave dans la mer. Le message majeur est que : les éclairages de la finance moderne et les théories ne sont pas totalement transposables d’un contexte à un autre. La spécificité environnementale, (phénomène culturel tel TUUK GUILI, l’absence de culture boursière, l’analphabétisme, l’imitation dans l’entrepreneuriat plutôt que la rationalité créative et l’efficience informationnelle etc.), peut influencer le développement des marchés boursiers en général et particulièrement celui de la BRVM. Pour comprendre et asseoir les bases de structures régionales efficaces et efficientes pour la mobilisation et l’allocation de l’épargne, la littérature économique et financière ne doit pas oublier de mener des investigations dans les pays subsahariens à une échelle microéconomique et sociologique. Het huidige onderzoek is een van de eerste over de BRVM en is dientengevolge in de oceaan van kennis slechts een steiger. De belangrijkste boodschap is dat de inzichten en de moderne financieringstheorieën niet volledig overzetbaar zijn naar elke context. De speciale kenmerken van de omgeving (TUUK GUILI, de afwezigheid van een beurscultuur, analfabetisme en imitatieneigingen zijn veeleer van belang dan rationaliteit en informatie-efficiency) beïnvloeden de ontwikkeling van de beurzen in het algemeen en die van de BRVM in het bijzonder. Teneinde doeltreffende en efficiënte regionale structuren neer te zetten voor de mobilisatie en de allocatie van de besparingen, dient de financiële literatuur aangevuld te worden met micro-economische en sociologische onderzoekingen in de Afrikaanse landen ten zuiden van de Sahara

Effect of Probiotic Giving on Digestive Function in Patients Post-Perforated Colorectal Cancer surgery

Background: One of the goals of colorectal cancer surgery is to facilitate the digestive tract to function properly. Surgery performed can lead new problems such as infection, sepsis, postoperative pain, and nausea vomiting.  Modulation of perioperative nutrition of intestinal microbiota such as probiotics is more and more applied as a strategy to reduce complications of elective surgical infection and accelerate the improvement of gastrointestinal symptoms such as flatus and defecation. The purpose of this study was to analyze the effect of giving probiotics on digestive function in patients after colorectal cancer surgery.Subjects and Methods: The subjects of this study were postoperative patients with colorectal cancer, with a total sample of 20. The sampling technique used non-random sampling. This type of the study is quasi experimental design with Post-test Only Control Design method. In this design, the sample is divided into two groups namely, group I was given probiotics and group II was not given probiotics then the follow up treatmen was conducted to assess the effect on the digestive function of patients after colorectal cancer surgery.Results: The majority of post-operative colorectal cancer patients were> 50 years (85%). The sex of post operative patients with colorectal cancer balanced between men and women, which was equally 50%. There was a significant difference between intestinal bowel surgery after colorectal cancer surgery which was given probiotics with no probiotics given (p <0.05). Similarly, post operative flatus colorectal cancer patients also had significant differences with the values (p <0.05). As for the defecation patients of post-surgery colorectal cancer , there was also a significant difference between the defecation patients of post-surgery of colorectal cancer surgery given probiotics and those not given probiotics with values (p <0.05).Conclusion: statistically, there was an effect of giving probiotics to digestive function including bowel sound, flatus, and defecation of post-surgery patient of colorectal cancer.Keywords: Probiotics, digestive function, colorectal cancerCorespondence: Impol Hutapea. Masters Program in Family Medicine, Sebelas Maret University. Email: [email protected] Journal of Medicine (2017), 2(2): 107-115https://doi.org/10.26911/theijmed.2017.02.02.0

Annexin A3 in sepsis: novel perspectives from an exploration of public transcriptome data

According to publicly available transcriptome datasets, the abundance of Annexin A3 (ANXA3) is robustly increased during the course of sepsis; however, no studies have examined the biological significance or clinical relevance of ANXA3 in this pathology. Here we explored this interpretation gap and identified possible directions for future research. Based on reference transcriptome datasets, we found that ANXA3 expression is restricted to neutrophils, is upregulatedin vitroafter exposure to plasma obtained from septic patients, and is associated with adverse clinical outcomes. Secondly, an increase in ANXA3 transcript abundance was also observedin vivo, in the blood of septic patients in multiple independent studies. ANXA3 is known to mediate calcium-dependent granules-phagosome fusion in support of microbicidal activity in neutrophils. More recent work has also shown that ANXA3 enhances proliferation and survival of tumour cells via a Caspase-3-dependent mechanism. And this same molecule is also known to play a critical role in regulation of apoptotic events in neutrophils. Thus, we posit that during sepsis ANXA3 might either play a beneficial role, by facilitating microbial clearance and resolution of the infection; or a detrimental role, by prolonging neutrophil survival, which is known to contribute to sepsis-mediated organ damage

Clinical phenotypes of acute heart failure based on signs and symptoms of perfusion and congestion at emergency department presentation and their relationship with patient management and outcomes

Objective To compare the clinical characteristics and outcomes of patients with acute heart failure (AHF) according to clinical profiles based on congestion and perfusion determined in the emergency department (ED). Methods and results Overall, 11 261 unselected AHF patients from 41 Spanish EDs were classified according to perfusion (normoperfusion = warm; hypoperfusion = cold) and congestion (not = dry; yes = wet). Baseline and decompensation characteristics were recorded as were the main wards to which patients were admitted. The primary outcome was 1-year all-cause mortality; secondary outcomes were need for hospitalisation during the index AHF event, in-hospital all-cause mortality, prolonged hospitalisation, 7-day post-discharge ED revisit for AHF and 30-day post-discharge rehospitalisation for AHF. A total of 8558 patients (76.0%) were warm+ wet, 1929 (17.1%) cold+ wet, 675 (6.0%) warm+ dry, and 99 (0.9%) cold+ dry; hypoperfused (cold) patients were more frequently admitted to intensive care units and geriatrics departments, and warm+ wet patients were discharged home without admission. The four phenotypes differed in most of the baseline and decompensation characteristics. The 1-year mortality was 30.8%, and compared to warm+ dry, the adjusted hazard ratios were significantly increased for cold+ wet (1.660; 95% confidence interval 1.400-1.968) and cold+ dry (1.672; 95% confidence interval 1.189-2.351). Hypoperfused (cold) phenotypes also showed higher rates of index episode hospitalisation and in-hospital mortality, while congestive (wet) phenotypes had a higher risk of prolonged hospitalisation but decreased risk of rehospitalisation. No differences were observed among phenotypes in ED revisit risk. Conclusions Bedside clinical evaluation of congestion and perfusion of AHF patients upon ED arrival and classification according to phenotypic profiles proposed by the latest European Society of Cardiology guidelines provide useful complementary information and help to rapidly predict patient outcomes shortly after ED patient arrival