Anti-corrosion behavior of olmesartan for soft-cast steel in 1 mol dm−3 HCL.

This study discusses the effects of temperature on corrosion inhibition for soft-cast steel by the pharmaceutically active drug olmesartan in 1 mol dm−3 HCl. The sufficient number of electron-rich elements and non-bonding π electrons in its structure favored a good capability for coating onto the electron-deficient steel surfaces. Theoretical and electrochemical measurements were carried out at the temperature region of 303 K to 333 K. Therefore, the experiment suggests that the inhibition efficiency of olmesartan increases with its increasing concentrations due to the adsorption. Additionally, even at a higher temperature of 333 K, the inhibitor molecules attain their stability towards corrosion resistance of steel surfaces. The adsorption of inhibitors on steel surfaces is spontaneously found to include the mixture of physisorption and chemisorption, and it obeys Temkin’s adsorption isotherm model. Theoretical and computational considerations were made using quantum chemical parameters and molecular dynamics simulations, which confirmed that the olmesartan has a suitable corrosion inhibitive capability intended for soft-cast steel in 1 mol dm−3 HCl. Additionally, scanning electron microscopic measurement was used to obtain a visual idea of the inhibitive action of the inhibitor attained by forming an adsorbed protective layer onto the steel surfaces. The minute concentration of olmesartan of about 10–50 ppm shows high inhibition efficiency of ~80%, even at elevated temperatures

A Survey on Energy Efficient Routing Protocols in Wireless Sensor Networks

Energy efficiency is one of the critical issues in the Wireless Sensor Networks (WSNs), since sensor devices are tiny and integrated with a limited capacity battery. In most of the advanced applications, WSNs operate in very harsh areas and not under supervision of human controls. Routing protocols play a significant role in energy balancing by incorporating the techniques that can reduce control overhead, proper data aggregation method and feasible path selection. It demands a unique requirement due to its frequent topology changes and distributive nature. One of the major concerns in the design of routing protocol in WSNs is efficient energy usage and prolonging Network lifetime. This paper mainly discusses different issues related to energy efficiency in routing protocols of all categories. It incorporates most recent routing protocols which improves the energy efficiency in various application environments. This paper also provides comprehensive details of each protocol which emphasize their principles and explore their advantages and limitations. These protocols belong to different classifications based on Network Structures, communication model, topology and QoS parameters. It also includes more relevant and prominent comparisons with all recent State-of-Art works

MEGOR: Multi-constrained Energy efficient Geographic Opportunistic Routing in Wireless Sensor Network

Providing better energy efficient network is the important critical issues in Wireless Sensor Networks. We presented Multi-constrained Energy efficient Geographic Opportunistic Routing algorithm that enhance the network lifetime based on efficient Geographic Opportunistic Routing. Geographic Opportunistic Routing algorithm uses single path multi hop routing technique in which packets are effectively routed from source to the sink node in a given geographical region. Proposed algorithm is devised with unique parameters viz., Single hop Packet Progress, Packet Reception Ratio, Residual Energy and Energy Density to select intermediate next nodes to forward the packet to sink node. The MEGOR exhibits better results in terms of delay, reliability, energy efficiency and network lifetime when compared with earlier state_of_art works

The Polygenic and Monogenic Basis of Blood Traits and Diseases

Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed cause a significant global health burden. Here we integrate data from UK Biobank and a large-scale international collaborative effort, including data for 563,085 European ancestry participants, and discover 5,106 new genetic variants independently associated with 29 blood cell phenotypes covering a range of variation impacting hematopoiesis. We holistically characterize the genetic architecture of hematopoiesis, assess the relevance of the omnigenic model to blood cell phenotypes, delineate relevant hematopoietic cell states influenced by regulatory genetic variants and gene networks, identify novel splice-altering variants mediating the associations, and assess the polygenic prediction potential for blood traits and clinical disorders at the interface of complex and Mendelian genetics. These results show the power of large-scale blood cell trait GWAS to interrogate clinically meaningful variants across a wide allelic spectrum of human variation. Analysis of blood cell traits in the UK Biobank and other cohorts illuminates the full genetic architecture of hematopoietic phenotypes, with evidence supporting the omnigenic model for complex traits and linking polygenic burden with monogenic blood diseases

Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Interpretation: By quantifying levels and trends in exposures to risk factors and the resulting disease burden, this assessment offers insight into where past policy and programme efforts might have been successful and highlights current priorities for public health action. Decreases in behavioural, environmental, and occupational risks have largely offset the effects of population growth and ageing, in relation to trends in absolute burden. Conversely, the combination of increasing metabolic risks and population ageing will probably continue to drive the increasing trends in non-communicable diseases at the global level, which presents both a public health challenge and opportunity. We see considerable spatiotemporal heterogeneity in levels of risk exposure and risk-attributable burden. Although levels of development underlie some of this heterogeneity, O/E ratios show risks for which countries are overperforming or underperforming relative to their level of development. As such, these ratios provide a benchmarking tool to help to focus local decision making. Our findings reinforce the importance of both risk exposure monitoring and epidemiological research to assess causal connections between risks and health outcomes, and they highlight the usefulness of the GBD study in synthesising data to draw comprehensive and robust conclusions that help to inform good policy and strategic health planning

Adsorption, thermodynamic, and electrochemical studies of ketosulfide for mild steel in acidic medium

The corrosion inhibition efficiency of ketosulfide was investigated by electrochemical methods in 1 M HCl solution at 303-333K. The polarization method showed mixed-type inhibition characteristics of ketosulfide. Adsorption behavior of ketosulfide was studied and which followed the Langmuir adsorption isotherm. Thermodynamic parameters were also calculated using Gibb's Helmholtz, Van't Hoff and basic themodynamic equations. Activation parameters were calculated using Arrhenius and transition state equations. The morphology of mild steel surface was examined by scanning electron microscopic images in the absence and presence of ketosulfide