Scaling limit of a non-relativistic model

I calculate the structure function for scattering from the two-body bound state in its lowest level in a non-relativistic model of confined scalar ``quarks'' of masses $m_A$ and $m_B$. The scaling limit in $x={\bf q}^2/2(m_A+m_B)q^0$ exists and is non-vanishing only for the values $x=m_A/(m_A+m_B)$ and $x=m_B/(m_A+m_B)$ which correspond to the fractions of the momentum of the two-body system carried by each of the ``quarks.'' In the scaling limit, the interference from scattering off of the two ``quarks'' vanishes. Thus the scaling limit of this model agrees with the parton picture.Comment: 10 pages, 3 figures not included, in LaTex, UMD 92-22

The E_{11} origin of all maximal supergravities

Starting from the eleven dimensional E_{11} non-linear realisation of M-theory we compute all possible forms, that is objects with totally antisymmetrised indices, that occur in four dimensions and above as well as all the 1-forms and 2-forms in three dimensions. In any dimension D, the D-1-forms lead to maximal supergravity theories with cosmological constants and they are in precise agreement with the patterns of gauging found in any dimension using supersymmetry. The D-forms correspond to the presence of space-filling branes which are crucial for the consistency of orientifold models and have not been derived from an alternative approach, with the exception of the 10-dimensional case. It follows that the gaugings of supergravities and the spacetime-filling branes possess an eleven dimensional origin within the E_{11} formulation of M-theory. This and previous results very strongly suggest that all the fields in the adjoint representation of E_{11} have a physical interpretation.Comment: 54 page

Confinement and scaling in deep inelastic scattering

We show that parton confinement in the final state generates large $1/Q^2$ corrections to Bjorken scaling, thus leaving less room for the logarithmic corrections. In particular, the $x$-scaling violations at large $x$ are entirely described in terms of power corrections. For treatment of these non-perturbative effects, we derive a new expansion in powers of $1/Q^2$ for the structure function that is free of infra-red singularities and which reduces corrections to the leading term. The leading term represents scattering from an off-mass-shell parton, which keeps the same virtual mass in the final state. It is found that this quasi-free term is a function of a new variable $\bar x$, which coincides with the Bjorken variable $x$ for $Q^2\to\infty$. The two variables are very different, however, at finite $Q^2$. In particular, the variable $\bar x$ depends on the invariant mass of the spectator particles. Analysis of the data at large $x$ shows excellent scaling in the variable $\bar x$, and determines the value of the diquark mass to be close to zero. $\bar x$-scaling allows us to extract the structure function near the elastic threshold. It is found to behave as $F_2\sim (1-x)^{3.7}$. Predictions for the structure functions based on $\bar x$-scaling are made.Comment: Discussion of target mass corrections is added. Accepted for publication in Phys. Rev.

Effect of Nyquist Noise on the Nyquist Dephasing Rate in 2d Electron Systems

We measure the effect of externally applied broadband Nyquist noise on the intrinsic Nyquist dephasing rate of electrons in a two-dimensional electron gas at low temperatures. Within the measurement error, the phase coherence time is unaffected by the externally applied Nyquist noise, including applied noise temperatures of up to 300 K. The amplitude of the applied Nyquist noise from 100 MHz to 10 GHz is quantitatively determined in the same experiment using a microwave network analyzer.Comment: 5 pages, 4 figures. Author affiliation clarified; acknowledgements modified. Replacement reason clarifie

Interaction Corrections to Two-Dimensional Hole Transport in Large rsr_{s} Limit

The metallic conductivity of dilute two-dimensional holes in a GaAs HIGFET (Heterojunction Insulated-Gate Field-Effect Transistor) with extremely high mobility and large $r_{s}$ is found to have a linear dependence on temperature, consistent with the theory of interaction corrections in the ballistic regime. Phonon scattering contributions are negligible in the temperature range of our interest, allowing comparison between our measured data and theory without any phonon subtraction. The magnitude of the Fermi liquid interaction parameter $F_{0}^{\sigma}$ determined from the experiment, however, decreases with increasing $r_{s}$ for r_{s}\agt22, a behavior unexpected from existing theoretical calculations valid for small $r_{s}$.Comment: 6 pages, 4 figure

Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits

Background: Primary central nervous system (CNS) neoplasms and brain metastases are routinely treated with whole-brain radiation. Long-term survival occurs in many patients, but their quality of life is severely affected by the development of cognitive deficits, and there is no treatment to prevent these adverse effects. Neuroinflammation, associated with activation of brain-resident microglia and infiltrating monocytes, plays a pivotal role in loss of neurological function and has been shown to be associated with acute and long-term effects of brain irradiation. Colony-stimulating factor 1 receptor (CSF-1R) signaling is essential for the survival and differentiation of microglia and monocytes. Here, we tested the effects of CSF-1R blockade by PLX5622 on cognitive function in mice treated with three fractions of 3.3 Gy whole-brain irradiation. Methods: Young adult C57BL/6J mice were given three fractions of 3.3 Gy whole-brain irradiation while they were on diet supplemented with PLX5622, and the effects on periphery monocyte accumulation, microglia numbers, and neuronal functions were assessed. Results: The mice developed hippocampal-dependent cognitive deficits at 1 and 3 months after they received fractionated whole-brain irradiation. The impaired cognitive function correlated with increased number of periphery monocyte accumulation in the CNS and decreased dendritic spine density in hippocampal granule neurons. PLX5622 treatment caused temporary reduction of microglia numbers, inhibited monocyte accumulation in the brain, and prevented radiation-induced cognitive deficits. Conclusions: Blockade of CSF-1R by PLX5622 prevents fractionated whole-brain irradiation-induced memory deficits. Therapeutic targeting of CSF-1R may provide a new avenue for protection from radiation-induced memory deficits

Current in the light-front Bethe-Salpeter formalism II: Applications

We pursue applications of the light-front reduction of current matrix elements in the Bethe-Salpeter formalism. The normalization of the reduced wave function is derived from the covariant framework and related to non-valence probabilities using familiar Fock space projection operators. Using a simple model, we obtain expressions for generalized parton distributions that are continuous. The non-vanishing of these distributions at the crossover between kinematic regimes (where the plus component of the struck quark's momentum is equal to the plus component of the momentum transfer) is tied to higher Fock components. Moreover continuity holds due to relations between Fock components at vanishing plus momentum. Lastly we apply the light-front reduction to time-like form factors and derive expressions for the generalized distribution amplitudes in this model.Comment: 12 pages, 6 figures, RevTex

Generalized parton distributions and double distributions for q q-bar pions

We consider two simple covariant models for pions (one with scalar and the other with spin-1/2 constituents). Pion generalized parton distributions are derived by integration over the light-cone energy. The model distributions are consistent with all known properties of generalized parton distributions, including positivity. We also construct the corresponding double distributions by appealing to Lorentz invariance. These ostensibly constructed double distributions lead to different generalized parton distributions that need not respect the positivity constraints. This inconsistency arises from the ambiguity inherent in defining double distributions in a one-component formalism (even in the absence of the Polyakov-Weiss term). We demonstrate that the correct model double distributions can be calculated from non-diagonal matrix elements of twist-two operators.Comment: 10 pages, 7 figures, RevTex4, reference added, typos correcte

Superconformal Selfdual Sigma-Models

A range of bosonic models can be expressed as (sometimes generalized) $\sigma$-models, with equations of motion coming from a selfduality constraint. We show that in D=2, this is easily extended to supersymmetric cases, in a superspace approach. In particular, we find that the configurations of fields of a superconformal $\mathfrak{G}/\mathfrak{H}$ coset models which satisfy some selfduality constraint are automatically solutions to the equations of motion of the model. Finally, we show that symmetric space $\sigma$-models can be seen as infinite-dimensional \tfG/\tfH models constrained by a selfduality equation, with \tfG the loop extension of $\mathfrak{G}$ and \tfH a maximal subgroup. It ensures that these models have a hidden global \tfG symmetry together with a local \tfH gauge symmetry.Comment: 21 pages; v2 few corrections and references added; v3 exposition change

Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity

Identifying genetic modifiers of familial amyotrophic lateral sclerosis (ALS) may reveal targets for therapeutic modulation with potential application to sporadic ALS. GGGGCC (G4C2) repeat expansions in the C9orf72 gene underlie the most common form of familial ALS, and generate toxic arginine-containing dipeptide repeats (DPRs), which interfere with membraneless organelles, such as the nucleolus. Here we considered senataxin (SETX), the genetic cause of ALS4, as a modifier of C9orf72 ALS, because SETX is a nuclear helicase that may regulate RNA–protein interactions involved in ALS dysfunction. After documenting that decreased SETX expression enhances arginine-containing DPR toxicity and C9orf72 repeat expansion toxicity in HEK293 cells and primary neurons, we generated SETX fly lines and evaluated the effect of SETX in flies expressing either (G4C2)58 repeats or glycine-arginine-50 [GR(50)] DPRs. We observed dramatic suppression of disease phenotypes in (G4C2)58 and GR(50) Drosophila models, and detected a striking relocalization of GR(50) out of the nucleolus in flies co-expressing SETX. Next-generation GR(1000) fly models, that show age-related motor deficits in climbing and movement assays, were similarly rescued with SETX co-expression. We noted that the physical interaction between SETX and arginine-containing DPRs is partially RNA-dependent. Finally, we directly assessed the nucleolus in cells expressing GR-DPRs, confirmed reduced mobility of proteins trafficking to the nucleolus upon GR-DPR expression, and found that SETX dosage modulated nucleolus liquidity in GR-DPR-expressing cells and motor neurons. These findings reveal a hitherto unknown connection between SETX function and cellular processes contributing to neuron demise in the most common form of familial ALS