720 research outputs found
Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1
Considerable evidence implicates DISC1 as a susceptibility gene for multiple psychiatric diseases. DISC1 has been intensively studied at the molecular, cellular and behavioral level, but its role in regulating brain connectivity and brain network function remains unknown. Here, we utilize a set of complementary approaches to assess the functional brain network abnormalities present in mice expressing a truncated Disc1 gene (Disc1tr Hemi mice). Disc1tr Hemi mice exhibited hypometabolism in the prefrontal cortex (PFC) and reticular thalamus along with a reorganization of functional brain network connectivity that included compromised hippocampal–PFC connectivity. Altered hippocampal–PFC connectivity in Disc1tr Hemi mice was confirmed by electrophysiological analysis, with Disc1tr Hemi mice showing a reduced probability of presynaptic neurotransmitter release in the monosynaptic glutamatergic hippocampal CA1–PFC projection. Glutamate system dysfunction in Disc1tr Hemi mice was further supported by the attenuated cerebral metabolic response to the NMDA receptor (NMDAR) antagonist ketamine and decreased hippocampal expression of NMDAR subunits 2A and 2B in these animals. These data show that the Disc1 truncation in Disc1tr Hemi mice induces a range of translationally relevant endophenotypes underpinned by glutamate system dysfunction and altered brain connectivity
Essential Role of the Cooperative Lattice Distortion in the Charge, Orbital and Spin Ordering in doped Manganites
The role of lattice distortion in the charge, orbital and spin ordering in
half doped manganites has been investigated. For fixed magnetic ordering, we
show that the cooperative lattice distortion stabilize the experimentally
observed ordering even when the strong on-site electronic correlation is taken
into account. Furthermore, without invoking the magnetic interactions, the
cooperative lattice distortion alone may lead to the correct charge and orbital
ordering including the charge stacking effect, and the magnetic ordering can be
the consequence of such a charge and orbital ordering. We propose that the
cooperative nature of the lattice distortion is essential to understand the
complicated charge, orbital and spin ordering observed in doped manganites.Comment: 5 pages,4 figure
On Properties of Vacuum Axial Symmetric Spacetime of Gravitomagnetic Monopole in Cylindrical Coordinates
We investigate general relativistic effects associated with the
gravitomagnetic monopole moment of gravitational source through the analysis of
the motion of test particles and electromagnetic fields distribution in the
spacetime around nonrotating cylindrical NUT source. We consider the circular
motion of test particles in NUT spacetime, their characteristics and the
dependence of effective potential on the radial coordinate for the different
values of NUT parameter and orbital momentum of test particles. It is shown
that the bounds of stability for circular orbits are displaced toward the event
horizon with the growth of monopole moment of the NUT object. In addition, we
obtain exact analytical solutions of Maxwell equations for magnetized and
charged cylindrical NUT stars.Comment: 16 pages, 3 figures, 1 tabl
Ergogenic and psychological effects of synchronous music during circuit-type exercise
This is the post print version of the article. The official published version can be obtained from the link below.Objectives: Motivational music when synchronized with movement has been found to improve performance in anaerobic and aerobic endurance tasks, although gender differences pertaining to the potential benefits of such music have seldom been investigated. The present study addresses the psychological and ergogenic effects of synchronous music during circuit-type exercise. Design: A mixed-model design was employed in which there was a within-subjects factor (two experimental conditions and a control) and a between-subjects factor (gender). Methods: Participants (N ¼ 26) performed six circuit-type exercises under each of three synchronous conditions: motivational music, motivationally-neutral (oudeterous) music, and a metronome control. Dependent measures comprised anaerobic endurance, which was assessed using the number of repetitions performed prior to the failure to maintain synchronicity, and post-task affect, which was assessed using Hardy and Rejeski’s (1989) Feeling Scale. Mixed-model 3 (Condition) X 2 (Gender) ANOVAs, ANCOVAs, and MANOVA were used to analyze the data. Results: Synchronous music did not elicit significant (p < .05) ergogenic or psychological effects in isolation; rather, significant (p < .05) Condition X Gender interaction effects emerged for both total repetitions and mean affect scores. Women and men showed differential affective responses to synchronous music and men responded more positively than women to metronomic regulation of their movements. Women derived the greatest overall benefit from both music conditions. Conclusions: Men may place greater emphasis on the metronomic regulation of movement than the remaining, extra-rhythmical, musical qualities. Men and women appear to exhibit differential responses in terms of affective responses to synchronous music
Proof of a conjecture of Polya on the zeros of successive derivatives of real entire functions
We prove Polya's conjecture of 1943: For a real entire function of order
greater than 2, with finitely many non-real zeros, the number of non-real zeros
of the n-th derivative tends to infinity with n. We use the saddle point method
and potential theory, combined with the theory of analytic functions with
positive imaginary part in the upper half-plane.Comment: 26 page
Quasi-fission reactions as a probe of nuclear viscosity
Fission fragment mass and angular distributions were measured from the
^{64}Ni+^{197}Au reaction at 418 MeV and 383 MeV incident energy. A detailed
data analysis was performed, using the one-body dissipation theory implemented
in the code HICOL. The effect of the window and the wall friction on the
experimental observables was investigated. Friction stronger than one-body was
also considered. The mass and angular distributions were consistent with
one-body dissipation. An evaporation code DIFHEAT coupled to HICOL was
developed in order to predict reaction time scales required to describe
available data on pre-scission neutron multiplicities. The multiplicity data
were again consistent with one-body dissipation. The cross-sections for touch,
capture and quasi-fission were also obtained.Comment: 25 pages REVTeX, 3 tables, 13 figures, submitted to Phys. Rev
Deflection and Rotation of CMEs from Active Region 11158
Between the 13 and 16 of February 2011 a series of coronal mass ejections
(CMEs) erupted from multiple polarity inversion lines within active region
11158. For seven of these CMEs we use the Graduated Cylindrical Shell (GCS)
flux rope model to determine the CME trajectory using both Solar Terrestrial
Relations Observatory (STEREO) extreme ultraviolet (EUV) and coronagraph
images. We then use the Forecasting a CME's Altered Trajectory (ForeCAT) model
for nonradial CME dynamics driven by magnetic forces, to simulate the
deflection and rotation of the seven CMEs. We find good agreement between the
ForeCAT results and the reconstructed CME positions and orientations. The CME
deflections range in magnitude between 10 degrees and 30 degrees. All CMEs
deflect to the north but we find variations in the direction of the
longitudinal deflection. The rotations range between 5\mydeg and 50\mydeg with
both clockwise and counterclockwise rotations occurring. Three of the CMEs
begin with initial positions within 2 degrees of one another. These three CMEs
all deflect primarily northward, with some minor eastward deflection, and
rotate counterclockwise. Their final positions and orientations, however,
respectively differ by 20 degrees and 30 degrees. This variation in deflection
and rotation results from differences in the CME expansion and radial
propagation close to the Sun, as well as the CME mass. Ultimately, only one of
these seven CMEs yielded discernible in situ signatures near Earth, despite the
active region facing near Earth throughout the eruptions. We suggest that the
differences in the deflection and rotation of the CMEs can explain whether each
CME impacted or missed the Earth.Comment: 18 pages, 6 figures, accepted in Solar Physic
Iron under Earth's core conditions: Liquid-state thermodynamics and high-pressure melting curve
{\em Ab initio} techniques based on density functional theory in the
projector-augmented-wave implementation are used to calculate the free energy
and a range of other thermodynamic properties of liquid iron at high pressures
and temperatures relevant to the Earth's core. The {\em ab initio} free energy
is obtained by using thermodynamic integration to calculate the change of free
energy on going from a simple reference system to the {\em ab initio} system,
with thermal averages computed by {\em ab initio} molecular dynamics
simulation. The reference system consists of the inverse-power pair-potential
model used in previous work. The liquid-state free energy is combined with the
free energy of hexagonal close packed Fe calculated earlier using identical
{\em ab initio} techniques to obtain the melting curve and volume and entropy
of melting. Comparisons of the calculated melting properties with experimental
measurement and with other recent {\em ab initio} predictions are presented.
Experiment-theory comparisons are also presented for the pressures at which the
solid and liquid Hugoniot curves cross the melting line, and the sound speed
and Gr\"{u}neisen parameter along the Hugoniot. Additional comparisons are made
with a commonly used equation of state for high-pressure/high-temperature Fe
based on experimental data.Comment: 16 pages including 6 figures and 5 table
Upper critical field for underdoped high-T_c superconductors. Pseudogap and stripe--phase
We investigate the upper critical field in a stripe--phase and in the
presence of a phenomenological pseudogap. Our results indicate that the
formation of stripes affects the Landau orbits and results in an enhancement of
. On the other hand, phenomenologically introduced pseudogap leads to a
reduction of the upper critical field. This effect is of particular importance
when the magnitude of the gap is of the order of the superconducting transition
temperature. We have found that a suppression of the upper critical field takes
place also for the gap that originates from the charge--density waves.Comment: 7 pages, 5 figure
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