Functional Meat and Meat Products: An Overview

A food can be regarded as functional if it is satisfactorily demonstrated to beneficially affect one or more target functions in the body, beyond adequate nutritional effects, in a way that is relevant to either improved health or well-being and/or to a reduction in the risk of disease. They are very important for health and are classified on various basis such as Supplementation of functional ingredients in diets of animals which includes Conjugated linoleic acid, Vitamin E, Omega-3 (ω3) fatty acids and Selenium; enrichment of functional ingredients in meat and meat products which includes functional foods from plant sources such as Soy proteins, Wheat proteins, Fibers, Broccoli and other Cruciferous Vegetables, Citrus Fruits, Tomatoes, Flaxseed, Herbs and spices as well as functional foods from animal sources such as Fish and Dairy Products like Whey protein and Probiotics and finally production of functional components during processing which includes Curing, Fermentation, Production of antibacterial compounds like Bacteriocin and Enzyme hydrolysis of proteins. Current status of functional meat products in world and India, safety issues and future prospects has been discussed

Finite temperature effects in Coulomb blockade quantum dots and signatures of spectral scrambling

The conductance in Coulomb blockade quantum dots exhibits sharp peaks whose spacings fluctuate with the number of electrons. We derive the temperature-dependence of these fluctuations in the statistical regime and compare with recent experimental results. The scrambling due to Coulomb interactions of the single-particle spectrum with the addition of an electron to the dot is shown to affect the temperature-dependence of the peak spacing fluctuations. Spectral scrambling also leads to saturation in the temperature dependence of the peak-to-peak correlator, in agreement with recent experimental results. The signatures of scrambling are derived using discrete Gaussian processes, which generalize the Gaussian ensembles of random matrices to systems that depend on a discrete parameter -- in this case, the number of electrons in the dot.Comment: 14 pages, 4 eps figures included, RevTe

Polyelectrolyte multilayer formation: electrostatics and short-range interactions

We investigate the phenomenon of multilayer formation via layer-by-layer deposition of alternating charge polyelectrolytes. Using mean-field theory, we find that a strong short-range attraction between the two types of polymer chains is essential for the formation of multilayers. The dependence of the required short-range attraction on the polymer charge fraction and salt concentration is calculated. For weak short-range attraction between any two adjacent layers, the adsorbed amount (per added layer) decays as the distance from the surface increases, until the chains stop adsorbing altogether. For strong short-range attraction, the adsorbed amount per layer increases after an initial decrease, and finally it stabilizes in the form of a polyelectrolyte multilayer that can be repeated many times.Comment: 8 pages, 7 figure

District level baseline survey of family planning program in Uttar Pradesh: Agra

The Ministry of Health and Family Welfare, Government of India (MOHFW), with assistance from the United States Agency for International Development (USAID), launched a landmark project in India’s most populous state, Uttar Pradesh. The Innovations in Family Planning Services Project was implemented under the management of the State lnnovations in Family Planning Services Agency (SIFPSA), Lucknow. Conducting baseline surveys in 15 selected districts of Uttar Pradesh was the first step in the project. The Uttar Pradesh baseline survey provided critical input by generating important demographic and family welfare program data at the district level. Over and above the 15 districts surveyed, it was decided that a baseline survey would be conducted in Agra district. In Agra, interviewers collected information from 2,864 ever-married women aged 13–49 in urban and rural areas of the district. As noted in this report, the primary aim of the baseline survey was to provide information at the district level for urban and rural areas separately

District level baseline survey of family planning program in Uttar Pradesh: Kanpur

The Ministry of Health and Family Welfare (MOHFW) with financial support from the United States Agency for International Development (USAID) has sponsored the Innovations in Family Planning Services Project (under the management of the State Innovations in Family Planning Services Agency, Lucknow). The project aims to reduce fertility through increasing accessibility, improving quality, and generating demand for family planning services. It attempts to achieve its objectives by supporting service innovations in the public and nongovernmental sector and through social marketing of contraceptives. These intervention strategies are expected to increase the couple protection rate of the state in general and of Kanpur Nagar in particular. One of the prerequisites is to carry out a baseline survey in selected districts of Uttar Pradesh. The BSUP is primarily a household survey with an overall target sample size of 37,000 ever married women ages 13–49 years. The Population Council has collaborated with a number of Indian Consulting Organizations (COs) for survey implementation. Each CO has carried out the survey in one or more districts. The baseline survey was initiated in 15 out of the state’s 63 districts. This report pertains to district Kanpur Nagar

District level baseline survey of family planning program in Uttar Pradesh: Jalaun

The Ministry of Health and Family Welfare (MOHFW), with support from the United States Agency for International Development (USAID), has sponsored the Innovations in Family Planning Services (IFPS) Project under the management of the State Innovations in Family Planning Services Agency, Lucknow. The project aims to reduce fertility by increasing accessibility, improving quality, and generating demand for family planning services. The project attempts to achieve its objectives by supporting service innovations in the public and nongovernmental sector, and through social marketing of contraceptives. These intervention strategies are expected to increase the couple protection rate of the state in general and of Jalaun in particular. One of the prerequisites is to carry out a baseline survey in selected districts of Uttar Pradesh. The BSUP is primarily a household survey with an overall target sample size of 37,000 ever-married women ages 13–49 years. The Population Council has collaborated with a number of Indian Consulting Organizations (COs) for survey implementation. Each CO has carried out the survey in one or more districts. The baseline survey was initiated in 15 out of the state’s 63 districts. This reports pertains to the district of Jalaun

Sinonasal Squamous Cell Carcinoma Survival Outcomes Following Induction Chemotherapy vs Standard of Care Therapy

Objective To compare oncologic outcomes in sinonasal squamous cell carcinoma (SNSCC) treated with standard of care (SOC) definitive therapy, consisting of surgery or chemoradiotherapy, vs induction therapy followed by definitive therapy. Study Design Retrospective review.SettingAcademic tertiary care hospital. Methods The medical records of patients with biopsy-proven SNSCC treated between 2000 and 2020 were reviewed for demographics, tumor characteristics, staging, treatment details, and oncologic outcomes. Patients were matched 1-to-1 by age, sex, and cancer stage according to treatment received. Time-to-event analyses were conducted. Results The analysis included 26 patients with locally advanced SNSCC who received either induction therapy (n = 13) or SOC (n = 13). Baseline demographics, Charlson Comorbidity Index, and median follow-up time were well balanced. Weekly cetuximab, carboplatin, and paclitaxel were the most common induction regimen utilized. Tolerance and safety to induction were excellent. Objective responses were observed in 11 of 13 patients receiving induction. No difference in disease-free survival was found between the induction and SOC groups at 1 or 3 years. However, when compared with SOC, induction therapy resulted in significant improvement in overall survival at 2 years (100% vs 65.3%, P = .043) and 3 years (100% vs 48.4%, P = .016) following completion of definitive therapy. Two patients in the SOC group developed metastatic disease, as compared with none in the induction group. Conclusions Induction therapy was safe and effective. When compared with SOC, induction therapy improved 3-year overall survival

A Case of Problematic Diffusion

Sex determination techniques have diffused rapidly in India, and are being used to detect female fetuses and subsequently to abort them. This technology has spread rapidly because it imparts knowledge that is of great value within the Indian context, and because it fits in neatly with the modernization dynamic within India, which itself has enmeshed with traditional patriarchal institutions to oppress Indian women. More research needs to be done on ways to stem the adoption of problematic innovations.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68396/2/10.1177_107554709401500301.pd

A tetravalent live attenuated dengue virus vaccine stimulates balanced immunity to multiple serotypes in humans

The four-dengue virus (DENV) serotypes infect several hundred million people annually. For the greatest safety and efficacy, tetravalent DENV vaccines are designed to stimulate balanced protective immunity to all four serotypes. However, this has been difficult to achieve. Clinical trials with a leading vaccine demonstrated that unbalanced replication and immunodominance of one vaccine component over others can lead to low efficacy and vaccine enhanced severe disease. The Laboratory of Infectious Diseases at the National Institutes of Health has developed a live attenuated tetravalent DENV vaccine (TV003), which is currently being tested in phase 3 clinical trials. Here we report, our study to determine if TV003 stimulate balanced and serotype-specific (TS) neutralizing antibody (nAb) responses to each serotype. Serum samples from twenty-one dengue-naive individuals participated under study protocol CIR287 (ClinicalTrials.gov NCT02021968) are analyzed 6 months after vaccination. Most subjects (76%) develop TS nAbs to 3 or 4 DENV serotypes, indicating immunity is induced by each vaccine component. Vaccine-induced TS nAbs map to epitopes known to be targets of nAbs in people infected with wild type DENVs. Following challenge with a partially attenuated strain of DENV2, all 21 subjects are protected from the efficacy endpoints. However, some vaccinated individuals develop post challenge nAb boost, while others mount post-challenge antibody responses that are consistent with sterilizing immunity. TV003 vaccine induced DENV2 TS nAbs are associated with sterilizing immunity. Our results indicate that nAbs to TS epitopes on each serotype may be a better correlate than total levels of nAbs currently used for guiding DENV vaccine development