Bone marrow transplantation alters the tremor phenotype in the murine model of globoid-cell leukodystrophy

Tremor is a prominent phenotype of the twitcher mouse, an authentic genetic model of Globoid-Cell Leukodystrophy (GLD, Krabbe’s disease). In the current study, the tremor was quantified using a force-plate actometer designed to accommodate low-weight mice. The actometer records the force oscillations caused by a mouse’s movements, and the rhythmic structure of the force variations can be revealed. Results showed that twitcher mice had significantly increased power across a broad band of higher frequencies compared to wildtype mice. Bone marrow transplantation (BMT), the only available therapy for GLD, worsened the tremor in the twitcher mice and induced a measureable alteration of movement phenotype in the wildtype mice. These data highlight the damaging effects of conditioning radiation and BMT in the neonatal period. The behavioral methodology used herein provides a quantitative approach for assessing the efficacy of potential therapeutic interventions for Krabbe’s disease

MECI: A Method for Eclipsing Component Identification

We describe an automated method for assigning the most probable physical parameters to the components of an eclipsing binary, using only its photometric light curve and combined colors. With traditional methods, one attempts to optimize a multi-parameter model over many iterations, so as to minimize the chi-squared value. We suggest an alternative method, where one selects pairs of coeval stars from a set of theoretical stellar models, and compares their simulated light curves and combined colors with the observations. This approach greatly reduces the parameter space over which one needs to search, and allows one to estimate the components' masses, radii and absolute magnitudes, without spectroscopic data. We have implemented this method in an automated program using published theoretical isochrones and limb-darkening coefficients. Since it is easy to automate, this method lends itself to systematic analyses of datasets consisting of photometric time series of large numbers of stars, such as those produced by OGLE, MACHO, TrES, HAT, and many others surveys.Comment: 25 pages, 7 figures, accepted for publication in Ap

Radial migration in galactic disks caused by resonance overlap of multiple patterns: Self-consistent simulations

We have recently identified a new radial migration mechanism resulting from the overlap of spiral and bar resonances in galactic disks. Here we confirm the efficiency of this mechanism in fully self-consistent, Tree-SPH simulations, as well as high-resolution pure N-body simulations. In all barred cases we clearly identify the effect of spiral-bar resonance overlap by measuring a bimodality in the changes of angular momentum in the disk, dL, whose maxima are near the bar's corotation and outer Lindblad resonance. This contrasts with the smooth distribution of dL for a simulation with no stable bar present, where strong radial migration is induced by multiple spirals. The presence of a disk gaseous component appears to increase the rate of angular momentum exchange by about 20%. The efficiency of this mechanism is such that galactic stellar disks can extend to over 10 scale-lengths within 1-3 Gyr in both Milky Way size and low-mass galaxies (circular velocity ~100 km/s). We also show that metallicity gradients can flatten in less than 1 Gyr rendering mixing in barred galaxies an order of magnitude more efficient than previously thought.Comment: replaced with accepted version: 5 pages, 5 figures (one new figure added), minor change

Variable Stars in the Globular Cluster M5. Application of the Image Subtraction Method

We present $V$-band light curves of 61 variables from the core of the globular cluster M5 obtained using a newly developed image subtraction method (ISM). Four of these variables were previously unknown. Only 26 variables were found in the same field using photometry obtained with DoPHOT software. Fourier parameters of the ISM light curves have relative errors up to 20 times smaller than parameters measured from DoPHOT photometry. We conclude that the new method is very promising for searching for variable stars in the cores of the globular clusters and gives very accurate relative photometry with quality comparable to photometry obtained by HST. We also show that the variable V104 is not an eclipsing star as has been suggested, but is an RRc star showing non-radial pulsations.Comment: submitted to MNRAS, 9 pages, 4 figure

A small source in Q2237+0305 ?

Microlensing in Q2237+0305 between 1985 and 1995 (eg. Irwin et al. 1989; Corrigan et al. 1991; Ostensen et al. 1996) has been interpreted in two different ways; as microlensing by stellar mass objects of a continuum source having dimensions significantly smaller than the microlens Einstein radius (ER) (eg. Wambsganss, Paczynski & Schneider 1990; Rauch & Blandford 1991), and as microlensing by very low mass objects of a source as large as 5 ER (Refsdal & Stabell 1993; Haugan 1996). In this paper we present evidence in favour of a small source. Limits on the source size (in units of ER) are obtained from the combination of limits on the number of microlens Einstein radii crossed by the source during the monitoring period with two separate light-curve features. Firstly, recently published monitoring data (Wozniak et al. 2000; OGLE web page) show large variations (~0.8-1.5 magnitudes) between image brightnesses over a period of 700 days or ~15% of the monitoring period. Secondly, the 1988 peak in the image A light-curve had a duration that is a small fraction (<0.02) of the monitoring period. Such rapid microlensing rises and short microlensing peaks only occur for small sources. We find that the observed large-rapid variation limits the source size to be <0.2 ER (95% confidence). The width of the light-curve peak provides a stronger constraint of <0.02 ER (99% confidence). The Einstein radius (projected into the source plane) of the average microlens mass (m) in Q2237+0305 is ER ~ 10^{17}\sqrt{m} cm. The interpretation that stars are responsible for microlensing in Q2237+0305 therefore results in limits on the continuum source size that are consistent with current accretion disc theory.Comment: 8 pages, 3 figures, accepted for publication in M.N.R.A.