A CLINICAL STUDY TO EVALUATE THE COMBINED EFFECT OF VIRECHANA KARMA, ARDRAKA KHANDA AND AMRUTA RAJANYADI KASHAYA IN THE MANAGEMENT OF SHEETAPITTA VIS-À-VIS CHRONIC URTICARIA

Sheetapitta is a clinical condition caused due to vitiation of Tridosha mainly by the contact of Sheetalavayu. It is characterized by Varati Damstravat Shotha (wheals), Kandu (itching), Daha (burning sensation), Toda (pricking pain), Jwara (fever) and Chardi (vomiting). Sheetapitta analogous to urticaria of western medicine. Urticaria is a vascular reaction pattern characterized by transient, erythematous and edematous wheals or papules of varying sizes and shapes which are usually pruritic. Episodes lasting more than 6 weeks are regarded as chronic urticaria. Present study is a single group open clinical trial with pre and post-test design with a sample size of 33 subjects. The diagnosis was based on the signs and symptoms of Sheetapitta vis-a-vis chronic urticaria and the assessment was based on Urticaria Activity Score which includes wheals and itch as its parameter. Subjects were administered with Virechana Karma followed by Ardraka Khandawith Amruta Rajanyadi Kashaya as Anupana for 30 days after Virechana Karma. The result obtained after the completion of intervention showed statistically highly significant with the P value 0.001 and also overall clinical improvement showed significant result in reducing the signs and symptoms of Sheetapitta vis-a-vis chronic urticaria. Sheetapitta being Tridoshajanya, Virechana Karma helped in Tridosha Nirharana (expelling dosha). Ardraka Khanda being Agnideepaka (appetiser), Sheeta Pittahara (disease pacifying action) and Rasayana (rejuvinator) followed by Amruta Rajanyadi Kashaya which is Kapha-Pitta Hara, Dahahara (reducing burning sensation) and Kanduhara (anti-itch) properties pacified the signs and symptoms of Sheetapitta. In combination of both Virechana Karma and Ardraka Khanda with Amruta- Rajanyadi Kashaya, majority of the subjects attained pacification of urticarial wheals and itching

Formation Constant of Transition Metal Complexes with Adenosine Biomolecule and Glutamic Acid and Isoleucine Amino Acids

Formation constants of transition metal complexes with Adenosine biomolecule, Glutamic acid and isoleucine amino acids have been studied pH metrically in 20% v/v ethyl alcohol and water medium at 30°C temperature and 0.1 M ionic strength. The proton ligand stability constant (pKa) of ligands and metal ligand stability constant (logK) of binary metal complexes were determined. It is correlated with atomic numbers, basicity of ligands, and atomic radii of metal ions. The transition metal complexes of ligands follow the Irving William natural order of stability.   &nbsp

Cooperation in one machine scheduling

Contains fulltext : 172966.pdf (publisher's version ) (Open Access

PHARMACEUTICAL AND ANALYTICAL STANDARDIZATION OF MAHA SHANKHA VATI

Khalveeya Rasa is the combinations of herbal, mineral and animal products, so that we can have the effects of all collectively in a single formula. It preserve the properties of freshly added Churna, Swarasa etc., with the help of Moorchita Parada i.e., Kajjali, Rasashindura & Hingula etc. Because of which Khalveeya Rasaushadhies occupies greater portion in therapeutics as compare to other Kalpana, Such as Vati, Gutika, Taila, Ghrita. In the present study three sample of “Maha Shankha Vati†have been prepared by adopting method describe in Ayurvedic Formulary of India (A.F.I.) Vol. 2 approved by government of India with some desire changes.AIMS: The aim of this study is to prepare three sample of “Maha Shankha Vati†for its Pharmacoanalytical standardization. And also prepare “Shankha Bhasmaâ€, “Hingullotha Parada†and processing of last three Sanskara of Parada. Analytical Standardization of self made Maha Shankha Vati & market sample of Maha Sankha Vati to compare analytically.RESULT: After evaluating organoleptic characters of the first three samples of self made Maha Shankha Vati revealed black colored substance in the form of Vati having Amla-Katu Rasa, Amla smell and smooth touch having pH 3.39. Similarly in case of market sample (fourth sample) shows black in colored in the form of Vati with Lavan-Katu in Rasa, Amla Smell and smooth touch having pH 4.37. Further the XRD pattern analysis of the combined sample of Maha Shankha Vati, reveals the presence of HgS, Caco3, NaCl. Same observation found in market sample.

Bioactivity of plants gums against pathogenic fungi

In order to investigate the bioactivity of gum of selected plants  against the economically important fungi like Alternaria alternata, Aspergillus niger, Curvularia lunata, Curvularia pellescence, Fusarium equiseti, Fusarium oxysporum, Macrophomina phaseolina, Penicillium digitatum, Penicillium chrysogenum and Rhizopus stolonifer  the experiments were carried out by using different concentrations of plant gum i.e. 1%, 5%, 10%. Gum Acacia arabica was found to promote the growth of fungi like Alternaria alternata, Aspergillus niger as the function of concentration of gum. Whereas the growth of fungi like Curvularia lunata, Fusarium equiseti, Fusarium oxysporum, Macrophomina phaseolina, Penicillium digitatum and Penicillium chrysogenum, were found to be inhibited by the 1% gum of Acacia arabica. But on the contrary the concentration of gum increased to level of 5% and 10%, the increase in dry mycelium weight of these fungi were found. The Rhizopus stolonifer was found to be suppressed at 10% concentration. Gum of Acacia chundra was found to promote the growth of fungi like Macrophomina phaseolina and Penicillium chrysogenum with the increased concentration of gum. On the other hand the fungi like Alternaria alternata, Aspergillus niger, Curvularia lunata, Fusarium equiseti, Fusarium oxysporum and Rhizopus stolonifer were found to be inhibited at 1% concentration of gum. But at 5% concentration the fungi like Alternaria alternata, Aspergillus niger, Curvularia pellecence, Fusarium equiseti and Rhizopus stolonifer showed the increased in dry mycelial weight. At 10 % concentration all fungi except Curvularia pellecence and Penicillium digitatum showed increase in dry mycelium weight. Similarly, gum of Azadirechta indica, Boswellia serrata and Butea monosperma showed fungitoxic activity at variable concentrations

Storage mycoflora of oilseeds: a review

Present paper deals with the review of storage seed mycoflor

Atrial septal aneurysm in adult patients: spectrum of clinical, echocardiographic presentation and to propose a new classification on the basis of trans-thoracic-two-dimensional echocardiography

An atrial septal aneurysm is a rare but well recognized cardiac abnormality of uncertain clinical relevance. ASA is definitively associated with congenital and acquired heart diseases but also can be presented as an isolated and totally asymptomatic entity. On the basis of our TTE finding we are proposing a new classification of ASA. We have classified ASA in to two major types: (A) Localized, and (B) Generalized. Both major types are further Sub-classified into 5 possible types on the basis of movements of ASA. New classification of ASA is as follows (1) A/B Type 1R: if the bulging is in the RA only (2) A/B  Type 2L: if the bulging is in the LA only (3) A / B  Type 3RL : if the major excursion bulges to the RA and lesser excursion bulges toward LA (4) A/B Type 4LR: if the maximal excursion of the atrial septal aneurysm is toward the LA with a lesser excursion toward the RA (5) A / B Type 5: if the atrial septal aneurysm movement is bidirectional and equidistant to both atria during the cardiorespiratory cycle. We found higher prevalence (2.24%) of ASA. A/B Type 2L and A/B Type 4LR were most common types. All type of ASA had particular clinical and echocardiographic characteristics. Mobile ASA and ASA with >10 mm excursion are associated with a higher risk of stroke

In vitro antimicrobial activity of crude extracts of Jatropha species

Leaf extracts, stem extract, roots extract, latex and oil of Jatropha curcas, J. glandulufera, J. integerrima and J. gossypofolia were screened in order to study their effect on plant pathogenic fungi Alternaria alternata, Aspergillus flavus, Aspergillus niger, Fusarium oxysporum, and Rhizoctonia solani and plant pathogenic bacteria Erwinia carotovora pv. Carotovora, Pseudomonas aeruginosa, Xanthomonas campestris pv. Citri and Xanthomonas campestris pv. mangiferaeindicae. Degree of variation of antifungal and antibacterial activity of different parts of Jatropha sp. was observed

NF-κB Mediates FGF Signal Regulation of msx-1 Expression

AbstractThe nuclear factor-κB (NF-κB) family of transcription factors is involved in proliferation, differentiation, and apoptosis in a stage- and cell-dependent manner. Recent evidence has shown that NF-κB activity is necessary for both chicken and mouse limb development. We report here that the NF-κB family member c-rel and the homeodomain gene msx-1 have partially overlapping expression patterns in the developing chick limb. In addition, inhibition of NF-κB activity resulted in a decrease in msx-1 mRNA expression. Sequence analysis of the msx-1 promoter revealed three potential κB-binding sites similar to the interferon-γ (IFN-γ) κB-binding site. These sites bound to c-Rel, as shown by electrophoretic mobility shift assay (EMSA). Furthermore, inhibition of NF-κB activity significantly reduced transactivation of the msx-1 promoter in response to FGF-2/-4, known stimulators of msx-1 expression. These results suggest that NF-κB mediates the FGF-2/-4 signal regulation of msx-1 gene expression