207 research outputs found

    Nutritional Consequences of Food Insecurity in a Rural New York State County

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    This study of women with children in a rural county of upstate New York examined the relationships of food insecurity and income with two nutritional consequences (adiposity and fruit and vegetables consumption), and assessed whether disordered eating patterns is a mediator for the effects of food insecurity and income on these nutritional consequences. Each of 193 respondents was interviewed twice in her home. Data were collected on household food stores, socioeconomic and demographic characteristics, methods of obtaining food, food program participation, household expenditures, food intake, the Radimer/Cornell hunger and food insecurity items, height, weight, frequency of fruit and vegetable consumption, and disordered eating patterns. Regression analysis was used to analyze the relationships of body mass index and an obesity classification with height, income, education, single parenthood, employment, food insecurity, disordered eating, and frequency of fruit and vegetable consumption. Regression analysis was also used to examine the relationships of disordered eating and frequency of fruit and vegetable consumption with the other variables. Lower income and unemployment were related to higher adiposity. The effects of income on adiposity were not mediated through disordered eating patterns or through fruit and vegetable consumption. Food insecurity was related to adiposity, and part of this effect of food insecurity was mediated through disordered eating. This mediating effect of disordered eating partially explained why those experiencing the least severe food insecurity were more likely to be overweight than those who were food secure, but those experiencing the most severe food insecurity were less likely to be overweight than those who were food secure. Food insecurity was related to lower fruit and vegetable consumption, but this did not translate into effects on adiposity.

    Estimating the prevalence of hunger and food insecurity: The validity of questionnaire-based measures for the identification of households

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    This study had three objectives: (1) to assess the validity of questionnaire-based measures in identifying households experiencing hunger and food insecurity, (2) to examine the interrelationships of different questionnaire-based measures, and (3) to examine the construction of a continuous food insecurity scale intended to differentiate three levels of food insecurity within households. A 1993 survey of 193 randomly sampled rural households with women and children living at home provided data on demographics, risk factors for food insecurity, Radimer/Cornell, CCHIP, and NHANES III hunger and food insecurity items, coping strategies, fruit and vegetable consumption, disordered eating behaviors, height, weight, dietary recall, and household food-stores inventory. This information was used to develop a definitive criterion measure for hunger and food insecurity, against which the Radimer/Cornell and CCHIP questionnaire-based measures, the NHANES III item, and the continuous food insecurity scale were tested for their specificity and sensitivity in measuring levels of food insecurity.

    A hydrodynamically optimized nano-electrospray ionization source and vacuum interface

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    The coupling of atmospheric pressure ionization (API) sources like electrospray ionization (ESI) to vacuum based applications like mass spectrometry (MS) or ion beam deposition (IBD) is done by differential pumping, starting with a capillary or pinhole inlet. Because of its low ion transfer efficiency the inlet represents a major bottleneck for these applications. Here we present a nano-ESI vacuum interface optimized to exploit the hydrodynamic drag of the background gas for collimation and the reduction of space charge repulsion. Up to a space charge limit of 40 nA we observe 100% current transmission through a capillary with an inlet and show by MS and IBD experiments that the transmitted ion beams are well defined and free of additional contamination compared to a conventional interface. Based on computational fluid dynamics modelling and ion transport simulations, we show how the specific shape enhances the collimation of the ion cloud. Mass selected ion currents in the nanoampere range available further downstream in high vacuum open many perspectives for the efficient use of electrospray ion beam deposition (ES-IBD) as a surface coating method

    The Effect of Repetitive Transcranial Magnetic Stimulation on Gamma Oscillatory Activity in Schizophrenia

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    Gamma (γ) oscillations (30-50 Hz) have been shown to be excessive in patients with schizophrenia (SCZ) during working memory (WM). WM is a cognitive process that involves the online maintenance and manipulation of information that is mediated largely by the dorsolateral prefrontal cortex (DLPFC). Repetitive transcranial magnetic stimulation (rTMS) represents a non-invasive method to stimulate the cortex that has been shown to enhance cognition and γ oscillatory activity during WM.We examined the effect of 20 Hz rTMS over the DLPFC on γ oscillatory activity elicited during the N-back task in 24 patients with SCZ compared to 22 healthy subjects. Prior to rTMS, patients with SCZ elicited excessive γ oscillatory activity compared to healthy subjects across WM load. Active rTMS resulted in the reduction of frontal γ oscillatory activity in patients with SCZ, while potentiating activity in healthy subjects in the 3-back, the most difficult condition. Further, these effects on γ oscillatory activity were found to be specific to the frontal brain region and were absent in the parieto-occipital brain region.We suggest that this opposing effect of rTMS on γ oscillatory activity in patients with SCZ versus healthy subjects may be related to homeostatic plasticity leading to differential effects of rTMS on γ oscillatory activity depending on baseline differences. These findings provide important insights into the neurophysiological mechanisms underlying WM deficits in SCZ and demonstrated that rTMS can modulate γ oscillatory activity that may be a possible avenue for cognitive potentiation in this disorder

    Neuroarchitecture of Aminergic Systems in the Larval Ventral Ganglion of Drosophila melanogaster

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    Biogenic amines are important signaling molecules in the central nervous system of both vertebrates and invertebrates. In the fruit fly Drosophila melanogaster, biogenic amines take part in the regulation of various vital physiological processes such as feeding, learning/memory, locomotion, sexual behavior, and sleep/arousal. Consequently, several morphological studies have analyzed the distribution of aminergic neurons in the CNS. Previous descriptions, however, did not determine the exact spatial location of aminergic neurite arborizations within the neuropil. The release sites and pre-/postsynaptic compartments of aminergic neurons also remained largely unidentified. We here used gal4-driven marker gene expression and immunocytochemistry to map presumed serotonergic (5-HT), dopaminergic, and tyraminergic/octopaminergic neurons in the thoracic and abdominal neuromeres of the Drosophila larval ventral ganglion relying on Fasciclin2-immunoreactive tracts as three-dimensional landmarks. With tyrosine hydroxylase- (TH) or tyrosine decarboxylase 2 (TDC2)-specific gal4-drivers, we also analyzed the distribution of ectopically expressed neuronal compartment markers in presumptive dopaminergic TH and tyraminergic/octopaminergic TDC2 neurons, respectively. Our results suggest that thoracic and abdominal 5-HT and TH neurons are exclusively interneurons whereas most TDC2 neurons are efferent. 5-HT and TH neurons are ideally positioned to integrate sensory information and to modulate neuronal transmission within the ventral ganglion, while most TDC2 neurons appear to act peripherally. In contrast to 5-HT neurons, TH and TDC2 neurons each comprise morphologically different neuron subsets with separated in- and output compartments in specific neuropil regions. The three-dimensional mapping of aminergic neurons now facilitates the identification of neuronal network contacts and co-localized signaling molecules, as exemplified for DOPA decarboxylase-synthesizing neurons that co-express crustacean cardioactive peptide and myoinhibiting peptides

    Processos de democracia direta: sim ou não? Os argumentos clássicos à luz da teoria e da prática

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    Regularmente surgem controvérsias sobre os processos de democracia direta, dos quais os mecanismos mais frequentes são a iniciativa popular, o plebiscito e o referendo. Por um lado, há autores que defendem a posição de que essas instituições tornam o jogo político mais lento, caro, confuso e ilegítimo; outros defendem a posição contrária e argumentam que processos de democracia direta são fundamentais para os cidadãos e a qualidade da democracia. O presente estudo analisa esse tema em torno de sete questões, baseadas em considerações teóricas e pesquisas empíricas: 1. A questão entre o minimalismo e o maximalismo democrático; 2. A concorrência entre maioria e minoria; 3. A concorrência entre as instituições representativas e os processos de democracia direta; 4. A questão da competência dos cidadãos; 5. A questão dos efeitos colaterais dos processos de democracia direta; 6. A questão do tamanho do eleitorado; 7. A questão dos custos dos processos de democracia direta. As sete questões são analisadas a partir de uma revisão bibliográfica que considera tanto fontes nacionais como internacionais. O estudo mostra que os processos de democracia direta podem ser um complemento para as instituições representativas em um sistema democrático. O bom desempenho dos plebiscitos, referendos e iniciativas populares depende tanto da regulamentação destes como também do desempenho das outras instituições políticas e da situação socioeconômica de um país. O estudo permite ampliar e aprofundar o debate sobre processos de democracia direta no Brasil
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