4,088 research outputs found

    The Right to Liberty in a Good Society

    Get PDF

    The Relationship of School Enrollment Size with Academic Achievement in Secondary Schools

    Get PDF
    This investigation was designed to examine the relationship between school enrollment size and academic achievement. Fourteen schools in the East-Central region of Illinois formed the focus of this study. The schools were grouped according to the number of enrolled students: small-size (less than 300); mid-size (300-799); and large-size (over 800). Data for the study were obtained from the 1987 School Report Cards. Report Cards are documents that were completed by schools in the state of Illinois to review the status of their educational programs. Data from the Report Cards included measures of academic achievement and also descriptive data on the schools involved in the study. Academic achievement was defined as a composite of a student\u27s progress in school as determined by graduation rates, achievement test scores, and core-curriculum enrollment rates. Low-income enrollment rates, pupil-teacher ratios, attendance rates, and per pupil expenditures were used to provide a descriptive profile of the schools involved in the study. Additional information regarding course offerings was obtained from school reports supplied by school administrators. Statistical analysis procedures were performed on these data and included frequency distributions and correlational analyses. Overall, it was found that school characteristics differed in small-size, mid-size and large-size schools. It was also determined that the characteristics associated with small-size schools were significantly related to academic achievement (p \u3c .05). The results of the study indicated that small-size schools facilitated for high levels of academic achievement

    Residual acceleration data on IML-1: Development of a data reduction and dissemination plan

    Get PDF
    A residual acceleration data analysis plan is developed that will allow principal investigators of low-gravity experiments to efficiently process their experimental results in conjunction with accelerometer data. The basic approach consisted of the following program of research: (1) identification of sensitive experiments and sensitivity ranges by order of magnitude estimates, numerical modelling, and investigator input; (2) research and development towards reduction, supplementation, and dissemination of residual acceleration data; and (3) implementation of the plan on existing acceleration data bases

    Re-examining Competition and Education in Collegiate Forensics: Establishing the Need for a Pedagogical Prerogative Perspective

    Get PDF
    The authors examine the dominant metaphors used to guide collegiate forensics practice during the last four decades. The interplay between education and competition serve as a focus for the analysis. The authors establish the need for a pedagogical prerogative perspective as a means of enhancing the educational value of intercollegiate individual events

    The proteosome inhibitor MG132 attenuates Retinoic Acid Receptor trans-activation and enhances trans-repression of Nuclear Factor κB. Potential relevance to chemo-preventive interventions with retinoids

    Get PDF
    BACKGROUND: Nuclear factor kappa B (NFκB) is a pro-malignant transcription factor with reciprocal effects on pro-metastatic and anti-metastatic gene expression. Interestingly, NFκB blockade results in the reciprocal induction of retinoic acid receptors (RARs). Given the established property of RARs as negative regulators of malignant progression, we postulated that reciprocal interactions between NFκB and RARs constitute a signaling module in metastatic gene expression and malignant progression. Using Line 1 tumor cells as a model for signal regulation of metastatic gene expression, we investigated the reciprocal interactions between NFκB and RARs in response to the pan-RAR agonist, all-trans retinoic acid (at-RA) and the pan-RAR antagonist, AGN193109. RESULTS: At-RA [0.1–1 μM] dose-dependently activated RAR and coordinately trans-repressed NFκB, while AGN193109 [1–10 μM] dose-dependently antagonized the effects of at-RA. At-RA and AGN193109 reciprocally regulate pro-metastatic matrix metalloprotease 9 (MMP 9) and its endogenous inhibitor, the tissue inhibitor of metalloprotease 1 (TIMP 1), in a manner consistent with the putative roles of NFκB and RAR in malignant progression. Activation of RAR concurs with its ubiquitination and proteosomal degradation. Accordingly, the proteosome inhibitor, MG132 [5 μM], blocked RAR degradation, quelled RAR trans-activation and enhanced RAR trans-repression of NFκB. CONCLUSION: We conclude that reciprocal interactions between NFκB and RARs constitute a signaling module in metastatic gene expression and malignant progression and propose that the dissociative effect of proteosome inhibitors could be harnessed towards enhancing the anticancer activity of retinoids

    Some Computational Insights on the Optimal Bus Transit Route Network Design Problem

    Get PDF
    The objective of this paper is to present some computational insights based on previous extensive research experiences on the optimal bus transit route network design problem (BTRNDP) with zonal demand aggregation and variable transit demand. A multi-objective, nonlinear mixed integer model is developed. A general meta-heuristics-based solution methodology is proposed. Genetic algorithms (GA), simulated annealing (SA), and a combination of the GA and SA are implemented and compared to solve the BTRNDP. Computational results show that zonal demand aggregation is necessary and combining metaheuristic algorithms to solve the large scale BTRNDP is very promising

    Originalism After Dobbs, Bruen, and Kennedy: The Role of History and Tradition

    Get PDF
    In three recent cases, the constitutional concepts of history and tradition have played important roles in the reasoning of the Supreme Court. Dobbs v. Jackson Women’s Health Organization relied on history and tradition to overrule Roe v. Wade. New York State Rifle & Pistol Ass’n v. Bruen articulated a history and tradition test for the validity of laws regulating the right to bear arms recognized by the Second Amendment. Kennedy v. Bremerton School District looked to history and tradition in formulating the test for the consistency of state action with the Establishment Clause. These cases raise important questions about the Court’s approach to constitutional interpretation and construction. Do Dobbs, Bruen, and Kennedy represent a new theory of constitutional interpretation and construction based on history and tradition? In the alternative, should the references to history and tradition in these opinions be understood through the lens of Constitutional Pluralism as modalities of constitutional argument? Finally, can the use of history and tradition in Dobbs, Bruen, and Kennedy be reconciled with the Supreme Court’s embrace of Public Meaning Originalism? Part I of this Article elucidates the constitutional concepts of history and tradition. Part II lays out four distinct roles that history and tradition can play: (1) as evidence of original meaning and purpose, (2) as modalities of constitutional argument within a constitutional pluralist framework, (3) as a novel constitutional theory, which we call “Historical Traditionalism,” and (4) as an implementing doctrine. Part III investigates the roles of history and tradition in Dobbs, Bruen, and Kennedy. Part IV articulates a comprehensive strategy for the incorporation of history and tradition in constitutional jurisprudence
    corecore