Epidemiology of ChiVMV and loss assessment in capsicum (Capsicum annum var. grossum Sendt)

The survey was conducted during rabi season (2021) to determine the incidence of mosaic disease of capsicum in major capsicum growing districts namely, Chikkaballapura, Kolar, Bengaluru rural and Ramanagar. The per cent incidence of mosaic disease based on symptoms in field was recorded, highest in Ramanagar (54.85%) and the least incidence of mosaic disease was observed in Chikkaballapura (26.85%). Transmission and host range studies under glasshouse conditions revealed that ChiVMV is transmitted mechanically. Among 16 host plants tested, 7 plant species (Nicotiana tabacum cv. Samsun, N. glutinosa, N. occidentalis, Datura metel, Physalis floridana, S. nigrum, Capsicum annum) were infected with the Chilli veinal mottle virus disease and the symptom could be seen in 20-25 days. The per cent transmission of ChiVMV by aphid Aphis gossypii was studied. The results showed that ChiVMV can be transmitted by A. gossypii. However, five aphids per plant showed highest per cent transmission (100%). The effect of different dates of inoculation on different plant growth parameters was also studied, the highest per cent disease transmission was observed in T1: Inoculation 15 days after sowing (100.00%)

Radiation and Mass Transfer Effects on Transient Free Convection Flow of a Dissipative Fluid past Semi-Infinite Vertical Plate with Uniform Heat and Mass Flux

Effect of radiation and mass transfer on the transient free convection flow of a dissipative past semi-infinite vertical plate with uniform heat and mass flux is analyzed, by taking into account the effect of viscous dissipation. This type of problems finds application in many technological and engineering fields such as plasma studies, petroleum industries, MHD energy generators, cooling of nuclear reactors, the boundary layer control in aerodynamics, crystal growth and furnace engineering. The Rosseland approximation is used to describe the radiative heat transfer in the limit of the optically thick fluid. The non-linear, coupled equations are solved using an implicit finite difference scheme of Crank-Nicolson type. Transient temperature, concentration and velocity profiles, local and average skinfriction coefficient, Nusselt number and Sherwood number are presented graphically and discussed. It is observed that, when the radiation parameter increases the velocity and temperature decrease accompanied by simultaneous reduction in both momentum and thermal boundary layers

Finite Difference Analysis of Radiative Free Convection Flow Past an Impulsively Started Vertical Plate with Variable Heat and Mass Flux

A numerical solution of the unsteady radiative free convection flow of an incompressible viscous fluid past an impulsively started vertical plate with variable heat and mass flux is presented here. This type of problem finds application in many technological and engineering fields such as rocket propulsion systems, spacecraft re-entry aerothermodynamics, cosmical flight aerodynamics, plasma physics, glass production and furnace engineering. The fluid is gray, absorbing-emitting but non-scattering medium and the Rosseland approximation is used to describe the radiative heat flux in the energy equation. The governing non-linear, coupled equations are solved using an implicit finite difference scheme. Numerical results for the velocity, temperature, concentration, the local and average skinfriction, the Nusselt and Sherwood number are shown graphically, for different values of Prandtl number, Schmidt number, thermal Grashof number, mass Grashof number, radiation parameter, heat flux exponent and the mass flux exponent. It is observed that, when the radiation parameter increases, the velocity and temperature decrease in the boundary layer. The local and average skin-friction increases with the increase in radiation parameter. For increasing values of radiation parameter the local as well as average Nusselt number increases

Limonene and BEZ 235 induce apoptosis in COLO-320 and HCT-116 colon cancer cells

Deregulated apoptosis is the hall mark of many cancers, therefore every defect in apoptosis pathway could be a potential target for cancer treatment.The anticancer mechanism of limonene could be multifactorial. However, induction of apoptosis in cancer cells is proposed as the predominant mechanism in several of preclinical studies. Therefore, we determined to investigate the role of apoptosis in the anticancer activity of limonene and BEZ235 combination in COLO-320 and HCT-116 colon cancer cells. Cells after treatments were assessed for apoptosis by DAPI staining for fluorescent microscopic examination of apoptotic cells, estimation of caspases activities, Bcl-2 family proteins in addition to cell cycle analysis by flowcytometry. Results show that both drugs induced apoptosis as demonstrated by increased caspases activity, significant alterations in pro and anti-apoptotic proteins of Bcl-2 family in promoting apoptosis and cell cycle arrest at G1 phase. Over all, it is indicated that limonene and BEZ exerted anticancer activity is mediated through induction of apoptosis involving mitochondria mediated intrinsic death pathway in the selected CRC cells

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Kinetic Studies of the Solvent Extraction of Molybdenum(VI) by 2- Thenoyltrifluoroacetone

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