63 research outputs found

    Indicators of affective empathy, cognitive empathy and social attention during emotional clips in relation to aggression in three-year-olds

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    Research indicates that impaired empathy is a risk factor of aggression and that social attention is important for empathy. The role of social attention in associations between empathy and aggression has not yet been fully elucidated. Therefore, indicators of affective empathy, cognitive empathy, social attention, and aggression were simultaneously assessed in children aged 45 months. A total of 61 mother–child dyads participated in a lab visit, during which maternal reports of aggression were obtained. Children watched three clips showing a sad, scared, and happy child, respectively, and a neutral social clip while heart rate was recorded. Heart rate change from nonsocial baseline clips to emotional clips was calculated as an index of affective empathy. Questions about the emotions of the children in the clips were asked to assess cognitive empathy. Social attention was defined as time spent looking at faces during the clips. Correlation analyses revealed negative associations between affective empathy and aggression and between social attention and aggression. Furthermore, multivariate linear regression analyses indicated that the association between affective empathy and aggression was moderated by social attention; the negative association between affective empathy and aggression was stronger in children with relatively reduced social attention. No association was found between cognitive empathy and aggression. Therefore, both affective empathy and social attention are important targets for early interventions that aim to prevent or reduce aggression

    Associations between empathy, inhibitory control, and physical aggression in toddlerhood

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    Impaired empathy has been associated with aggression in children, adolescents and adults, but results have been contradictory for the preschool period. Impaired inhibitory control also increases the risk of aggression, and possibly moderates empathy‐aggression associations. The current study investigated whether empathy and inhibitory control are associated with aggression in toddlerhood. Furthermore, we aimed to clarify the role of inhibitory control in empathy and aggression, specifically, whether inhibitory control moderates the association between empathy and aggression. During a laboratory visit at age 30 months (N = 103), maternal reports of physical aggression were obtained and child inhibitory control was examined using a gift delay task. Empathy was examined by obtaining behavioral observations and recording physiological responses (heart rate response and respiratory sinus arrhythmia response) to an empathy‐eliciting event (i.e., simulated distress). Reduced inhibitory control was associated with more aggression. Behavioral and physiological indicators of empathy were not associated with aggression. Hierarchical regression analyses revealed an interaction effect of heart rate response to distress simulation with inhibitory control in the prediction of aggression. Post hoc analyses indicated a negative association between heart rate response and aggression when inhibitory control was high, but a positive association was found in toddlers who demonstrated low inhibitory control. These results suggest that children are less aggressive when they have both high levels of empathy and inhibitory control. Therefore, both empathy and inhibition are important targets for interventions aiming to reduce or prevent aggression at a young age

    Infant emotional responses to challenge predict empathic behavior in toddlerhood

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    Although emotional responses are theorized to be important in the development of empathy, findings regarding the prediction of early empathic behavior by infant behavioral and physiological responses are mixed. This study examined whether behavioral and physiological responses to mild emotional challenge (still face paradigm and car seat task) in 118 infants at age 6 months predicted empathic distress and empathic concern in response to an empathy‐evoking task (i.e, experimenter's distress simulation) at age 20 months. Correlation analyses, corrected for sex and baseline levels of physiological arousal, showed that stronger physiological and behavioral responses to emotional challenge at age 6 months were positively related to observed empathic distress, but not empathic concern, at age 20 months. Linear regression analyses indicated that physiological and behavioral responses to challenge at 6 months independently predicted empathic distress at 20 months, which suggests an important role for both physiological and behavioral emotional responses in empathy development. In addition, curvilinear regression analyses showed quadratic associations between behavioral responses at 6 months, and empathic distress and empathic concern at 20 months, which indicates that moderate levels of behavioral responsivity predict the highest levels of empathic distress and empathic concern

    Farmacokinetiek en plasmaspiegels van tricyclische antidepressiva bij bejaarden

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    Interpretatie van bloedspiegels van tricyclische antidepressiva bij fatale intoxicaties

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    Mild impairments of motor imagery skills in children with DCD

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    Item does not contain fulltextIt has been hypothesized that the underlying mechanism of clumsy motor behaviour in children with Developmental Coordination Disorder (DCD) is caused by a deficit in the internal modelling for motor control. An internal modelling deficit can be shown on a behavioural level by a task that requires motor imagery. Motor imagery skills are suggested to be related to anticipatory action planning, but motor imagery and action planning have not been tested within the same child. In the present study, action planning and motor imagery skills were assessed in 82 children between 7 and 12 years of age. Twenty-one of these children met the criteria for DCD, which was assessed by the McCarron Assessment of Neuromuscular Development and 56 of these children were used in the control group. Motor imagery was tested by a mental rotation task of hands that were shown from a back and palm point of view. The results show that motor imagery is affected in children with DCD but only in conditions with complex task constraints (i.e., rotation of hand stimuli presented in palm view). These results provide partial support for the internal modelling deficit hypothesis. We were not able to elicit motor planning deficits in this group, however, and argue that more complex planning tasks may be needed to identify such deficits

    Instability of the DNPH-formaldehyde derivative in the certified reference material BCR-551 stored at -70 °C but not at -20 °C

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    During the post-certification stability monitoring of the certified reference material (CRM) BCR-551 (DNPHderivatives dissolved in acetonitrile), a decreased concentration of one of the analytes of this CRM, formaldehyde DNPH-derivative, was detected in reference samples (stored at -70 °C) while normal "on sale" samples (stored at -20 °C) remained stable. This behaviour is contrary to the expectation of better stability at lower temperatures. Apparently, the formaldehyde DNPH-derivative reacts with dinitrophenylhydrazine (DNPH) left-over from the synthesis phase, to produce two new substances. These substances have been elucidated as C13H12N8O8 (substance 1) and C20H16N12O12 (substance 2) which, based on their structure, are suggested to be produced consecutively: DNPH + formaldehyde DNPH-derivative -> substance 1 substance 1 + formaldehyde DNPH-derivative -> substance 2 Since acetonitrile freezes at -45 °C, reference samples are frozen at -70 °C while normal samples are still liquid at -20 °C. We believe that this leads to a cryo-concentration of the solutes above the eutectic point and thus to an increased reaction rate in the reference samples. This case demonstrates that care should be taken when extrapolating stability results towards conditions that never have been tested, especially if phase transitions are involved, even at temperature as low as -70 °C. Furthermore, a slower degradation rate at lower temperatures can be overcompensated by a higher concentration due to cryo-concentration above the eutectic temperature.JRC.D.2-Standards for Innovation and sustainable Developmen

    Insufficient health care capacity for patients requiring immediate admission; a prospective study in a general hospital in Amsterdam, March-November 2001

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    OBJECTIVE: To gain insight into the shortage in health care capacity for patients who require immediate admission to hospital.DESIGN: Prospective, descriptive.METHOD: During the period 1 March-30 November 2001, data were collected on all patients presenting at the casualty department at the Sint Lucas Andreas Hospital in Amsterdam, the Netherlands, who had a surgical, internal medicine or neurological condition which required immediate admission and who could not be admitted due to a shortage in health care capacity. The following data were registered: date of transfer, age, gender, diagnosis, referring specialty, time of telephone call, accepting hospital and time of acceptance. During the same period, the surgery department also noted details of patients requiring immediate admission or transfer whom they turned away after presentation via the telephone by either the general practitioner or a different hospital.RESULTS: 131 patients could not be admitted, 68 men and 63 women with a mean age of 69 years. The distribution across the specialties was as follows: surgery: 63 patients (48%; mean age: 68 years); internal medicine: 48 patients (37%; 65 years); neurology: 20 patients (15%; 74 years). The most common reasons for admission were proximal femur fractures (24; 18%) and gastrointestinal disorders (27; 21%). Mean duration from making the telephone call until acceptance elsewhere was 70 min (range: 1-330) for surgery, 42 min (5-180) for internal medicine and 116 min (10-870) for neurology. The transfer of patients with proximal femur fractures (97 min) and cerebrovascular accident (129 min) took the longest. During the same period, 170 patients were refused by the department of surgery for first-time admission or transfer.</p
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