Preliminary Study on the Impact of Water Quality and Irrigation Practices on Soil Salinity and Crop Production, Gergera Watershed, Atsbi-Wonberta, Tigray, Northern Ethiopia

Possible long term effects on soil salinity and crop production due to the quality of water and irrigation practices is assessed in an area in Gergera Watershed in Atsbi-Wonberta, Tigray, northern Ethiopia. Ten water  samples collected from hand-dug wells and small household ponds, and thirty soil samples from different depths up to ~100cm were tested for  various parameters such as TDS, pH, anions and cations. Data indicate that both water and soil in terms of quality are acceptable for irrigation  purposes. However, at present the soil salinity is not a serious issue but the data suggests its possible increase with time as indicated by two samples. Some of the issues such as use of sprinklers, organic manure, blending, seasonal crops are discussed in the light of maintaining the  required quality, proper utilization of soil and water resources, and for sustainable development.Keywords: Watershed, Water quality, Soil quality, Hand-dug wells, House-hold Ponds

The Gap between Surgical Resident and Faculty Surgeons Concerning Operating Theatre Teaching: Report from Addis Ababa, Ethiopia

Background: In a continent like Africa where the number of surgeons is alarmingly few, training of a large number of residents is the way forward. However, sudden expansion in the number of trainees in an existing teaching environment may bring the quality of the most fundamentaleducation i.e. operation room teaching into question.Method: We wanted to investigate the different perceptions of our surgeons-under-training and faculty concerning preoperative preparation, intra operative teaching and postoperative feedback. A validated questionnaire was administered to our surgical residents and faculty at the Addis Ababa University, School of Medicine, Department of Surgery. Results were analyzed with 2-sample t tests, comparing Likert scores. Findings were significant if the p value was < 0.05.Results: Forty residents (15 second year, 15 third years and 10 final years) and 30 faculty members completed the survey. With respect to preoperative preparation, faculty were significantly more likely to claim that residents’ preparation in terms of reading is low (3.77 vs 2.45; p=0.001) and anatomy review (3.73 vs 2.34; p=0.001) before the procedure. There was a very significant difference with regards to intra-operative teaching activities, i.e teaching of the operative steps (2.60 vs 3.79; p=0.048), instrument handling (2.30 vs 3.72; p=0.002), and surgical technique (2.23vs 3.83; p= 0.001). Residents’ perception of the effort of the faculty to act as a teacher in the operating room was significantly lower compared to the faculty (2.13 vs 3.94; p=0.002). Postoperatively, significant differences were found in perceptions of positive feedback (2.48 vs 3.86; p=0.01) and feedback on areas to improve (1.85 vs 3.34; p=0.001).Conclusion: There is a universal agreement on the need to improve the current residency training. However, the difference between resident and faculty in the teaching-learning process is alarmingly significant. As there is no substitute for the intra-operative training of residents, every effort must be made to not to trade off number of graduates with quality and  competence of surgeons-under-training.  Keywords: Resident, Surgeons, Operating, Theatre, Teachin

Assess Farmer’s Skills on Chickpea (Cicer arietinum (L.) Seed Qualities and its Components in East showa Zone, Ethiopia

In Ethiopia, chickpea is an important grain legume next to faba bean and common bean both in terms of area coverage and production. It is mainly grown as a source of food protein, income generation, and soil fertility restoration and used for animal feed. Quality seed production and associated technologies could be mentioned among the major challenges that limit chickpea production and productivity in Ethiopia. This study was therefore conducted to investigate the experiences and perception of farmers regarding chickpea seed quality. Two representative districts (Ada and Lume) were systematically selected from the major chickpea growing area. 84 seed producers were randomly selected from the districts and interviewed to gather information on perception and experience of chickpea seed production systems. The survey result indicated high adoption rate for improved chickpea varieties in the study areas. Arerti and Habru were among the dominant and widely grown chickpea varieties in the districts. Half of the farmers in the study area experienced that seed quality test are mandatory process in the seed production systems.In the study area, disease is as a major challenge for chickpea seed production so; the seed regulatory unit should consider future work associated to seed health

Assessment of seed quality parameters in different seed sources of chickpea (Cicer arietinum (L.)

In Ethiopia, chickpea is an important grain legume next to faba bean and common bean. Quality seed production and associated technologies could be mentioned among the major challenges that limit chickpea production and productivity in Ethiopia. This study was conducted to assess the quality of seeds at different generation classes as obtained from various sources that would contribute an estimate of more than half the chickpea seed suppliers. Thirty one seed samples taken from ten different formal seed sources and four seed classes were used to test physical, physiological and seed health parameters. The result of the laboratory study indicated that seed sources and classes have affected highly significantly the moisture content and hundred seed weight. Correlation analysis showed that seed purity had positive and highly significantly influenced standard germination, vigor index, seedling dry weight and hundred seed weight. Similarly, vigor index was correlated positively and highly significantly with speed of standard germination and root length. Considering seed health as standard quality parameters showed that no seed sources and classes met the standards set by the national seed quality. The seed regulatory unit should be considered in the future in enhancing the seed standard levels and on undermined factors associated to seed health

Targeted molecular therapy of anaplastic thyroid carcinoma with AEE788

Anaplastic Thyroid Carcinoma (ATC) is one of the most aggressive human malignancies with a mean survival of only 6 months. The poor prognosis of patients with ATC reflects the current lack of curative therapeutic options and the need for development of novel therapeutic strategies. In this study, we report the results of a preclinical study of AEE788, a dual inhibitor of Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor (VEGFR) tyrosine kinases, against ATC. AEE788 was able to inhibit the proliferation and induce apoptosis of ATC cell lines in vitro. Administration of AEE788, alone and in combination with paclitaxel, to athymic nude mice bearing s.c. ATC xenografts inhibited the growth of ATC xenografts by 44% and 69%, respectively, compared with the control group. Furthermore, tumors from mice treated with AEE788, alone and in combination with paclitaxel, showed increase in apoptosis of tumor cells by ∼6- and 8-fold, respectively, compared with the control group. The microvessel density within the ATC xenografts was decreased by >80% in the mice treated with AEE788 alone and in combination with paclitaxel compared with the control group. Lastly, immunofluorescence microscopy showed the inhibition of EGFR autophosphorylation on the tumor cells as well as the inhibition of VEGFR-2 autophosphorylation on tumor endothelium. Considering the fact that curative options seldom exist for patients with ATC, concurrent inhibition of EGFR and VEGFR tyrosine kinases seems to be a valid and promising anticancer strategy for these patients

Analysis of maternal and newborn training curricula and approaches to inform future trainings for routine care, basic and comprehensive emergency obstetric and newborn care in the low- and middle-income countries: Lessons from Ethiopia and Nepal

Program managers routinely design and implement specialised maternal and newborn health trainings for health workers in low- and middle-income countries to provide better-coordinated care across the continuum of care. However, in these countries details on the availability of different training packages, skills covered in those training packages and the gaps in their implementation are patchy. This paper presents an assessment of maternal and newborn health training packages to describe differences in training contents and implementation approaches used for a range of training packages in Ethiopia and Nepal. We conducted a mixed-methods study. The quantitative assessment was conducted using a comprehensive assessment questionnaire based on validated WHO guidelines and developed jointly with global maternal and newborn health experts. The qualitative assessment was conducted through key informant interviews with national stakeholders involved in implementing these training packages and working with the Ministries of Health in both countries. Our quantitative analysis revealed several key gaps in the technical content of maternal and newborn health training packages in both countries. Our qualitative results from key informant interviews provided additional insights by highlighting several issues with trainings related to quality, skill retention, logistics, and management. Taken together, our findings suggest four key areas of improvement: first, training materials should be updated based on the content gaps identified and should be aligned with each other. Second, trainings should address actual health worker performance gaps using a variety of innovative approaches such as blended and self-directed learning. Third, post-training supervision and ongoing mentoring need to be strengthened. Lastly, functional training information systems are required to support planning efforts in both countries

Epidermal Growth Factor Receptor (EGFR) is overexpressed in anaplastic thyroid cancer and the EGFR inhibitor gefitinib inhibits the growth of anaplastic thyroid cancer

Purpose: No effective treatment options currently are available to patients with Anaplastic Thyroid Cancer (ATC), resulting in high mortality rates. Epidermal Growth Factor (EGF) has been shown to play a role in the pathogenesis of many types of cancer and its receptor (EGFR) provides an attractive target for molecular therapy. Experimental Design: The expression of EGFR was determined in ATC in vitro and in vivo and in human tissue arrays of ATC. We assessed the potential of the EGFR inhibitor gefitinib (“Iressa,” ZD1839) to inhibit EGFR activation in vitro and in vivo, inhibit ATC cellular proliferation, induce apoptosis and reduce the growth of ATC cells in vivo when administered alone and in combination with paclitaxel. Results: EGFR was overexpressed in ATC cell lines in vitro and in vivo and in human ATC specimens. Activation of EGFR by EGF was blocked by the addition of gefitinib. In vitro studies showed that gefitinib greatly inhibited cellular proliferation and induced apoptosis in ATC cell lines and slowed tumor growth in a nude mouse model of thyroid carcinoma cells injected subcutaneously. Conclusions: ATC cells consistently overexpress EGFR, rendering this receptor a potential target for molecular therapy. Gefitinib effectively blocks activation of EGFR by EGF, inhibits ATC cellular proliferation and induces apoptosis in vitro. Our in vivo results show that gefitinib has significant antitumor activity against ATC in a subcutaneous nude mouse tumor model and therefore is a potential candidate for human clinical trials

Rapidity and centrality dependence of particle production for identified hadrons in Cu+Cu collisions at sNN=200\sqrt{s_{NN}} = 200 GeV

The BRAHMS collaboration has measured transverse momentum spectra of pions, kaons, protons and antiprotons at rapidities 0 and 3 for Cu+Cu collisions at $\sqrt{s_{NN}} = 200$ GeV. As the collisions become more central the collective radial flow increases while the temperature of kinetic freeze-out decreases. The temperature is lower and the radial flow weaker at forward rapidity. Pion and kaon yields with transverse momenta between 1.5 and 2.5 GeV/c are suppressed for central collisions relative to scaled $p+p$ collisions. This suppression, which increases as the collisions become more central is consistent with jet quenching models and is also present with comparable magnitude at forward rapidity. At such rapidities initial state effects may also be present and persistence of the meson suppression to high rapidity may reflect a combination of jet quenching and nuclear shadowing. The ratio of protons to mesons increases as the collisions become more central and is largest at forward rapidities.Comment: 19 pages, 11 figures and 6 table

Rapidity dependence of deuteron production in Au+Au collisions at sNN\sqrt{s_{NN}} = 200 GeV

We have measured the distributions of protons and deuterons produced in high energy heavy ion Au+Au collisions at RHIC over a very wide range of transverse and longitudinal momentum. Near mid-rapidity we have also measured the distribution of anti-protons and anti-deuterons. We present our results in the context of coalescence models. In particular we extract the "volume of homogeneity" and the average phase-space density for protons and anti-protons. Near central rapidity the coalescence parameter $B_2(p_T)$ and the space averaged phase-space density $(p_T)$ are very similar for both protons and anti-protons. For protons we see little variation of either $B_2(p_T)$ or the space averaged phase-space density as the rapidity increases from 0 to 3. However both these quantities depend strongly on $p_T$ at all rapidities. These results are in contrast to lower energy data where the proton and anti-proton phase-space densities are different at $y$=0 and both $B_2$ and $f$ depend strongly on rapidity.Comment: Document updated after proofs received from PR

Mapping Robots to Therapy and Educational Objectives for Children with Autism Spectrum Disorder

The aim of this study was to increase knowledge on therapy and educational objectives professionals work on with children with autism spectrum disorder (ASD) and to identify corresponding state of the art robots. Focus group sessions (n = 9) with ASD professionals (n = 53) from nine organisations were carried out to create an objectives overview, followed by a systematic literature study to identify state of the art robots matching these objectives. Professionals identified many ASD objectives (n = 74) in 9 different domains. State of the art robots addressed 24 of these objectives in 8 domains. Robots can potentially be applied to a large scope of objectives for children with ASD. This objectives overview functions as a base to guide development of robot interventions for these children