One-step synthesis of methyl arylacetates from acetophenones using lead(IV) acetate

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A novel, general method for the synthesis of 2-methyl-substituted and 2-unsubstituted methyl 5-aryl-2,4-pentadienoates

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Partial reductive demethylthiolation of a-ketoketene S,S-acetals with sodium borohydride/nickel chloride: a new, general method for 2-methylthio-1-alkenyl ketones

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A three component one-pot synthesis of N-amino-2-pyridone derivatives catalyzed by KF-Al₂O₃

<p>Synthesis of 1,6-diamino-4-phenyl-3,5-dicyano-2-pyridone derivatives <i>via</i> a one-pot, three-component reaction of aryl aldehydes, malononitrile, and cyanoacetic hydrazide at room temperature using KF-Al₂O₃ as a recyclable catalyst have been developed. The reaction proceeds through the initial Knoevenagel condensation between aldehyde and malononitrile in the presence of KF-Al₂O₃ to form the benzylidene derivative which then undergoes Michael addition with cyanoacetic hydrazide followed by intramolecular cyclization of the resulting intermediate to produce the N-amino-2-pyridones in good to excellent yields. The structure of the synthesized compounds were characterized and established on the basis of their spectral data analysis and single-crystal XRD analysis.</p