An Sveir Model for Assessing Potential Impact of an Imperfect Anti-SARS Vaccine

The control of severe acute respiratory syndrome (SARS), a fatal contagious viral disease that spread to over 32 countries in 2003, was based on quarantine of latently infected individuals and isolation of individuals with clinical symptoms of SARS. Owing to the recent ongoing clinical trials of some candidate anti-SARS vaccines, this study aims to assess, via mathematical modelling, the potential impact of a SARS vaccine, assumed to be imperfect, in curtailing future outbreaks. A relatively simple deterministic model is designed for this purpose. It is shown, using Lyapunov function theory and the theory of compound matrices, that the dynamics of the model are determined by a certain threshold quantity known as the control reproduction number (Rv). If Rv ≤ 1, the disease will be eliminated from the community; whereas an epidemic occurs if Rv \u3e 1. This study further shows that an imperfect SARS vaccine with infection-blocking efficacy is always beneficial in reducing disease spread within the community, although its overall impact increases with increasing efficacy and coverage. In particular, it is shown that the fraction of individuals vaccinated at steady-state and vaccine efficacy play equal roles in reducing disease burden, and the vaccine must have efficacy of at least 75% to lead to effective control of SARS (assuming R0 = 4). Numerical simulations are used to explore the severity of outbreaks when Rv \u3e 1

Towards democratic intelligence oversight: Limits, practices, struggles

Despite its common usage, The meaning of 'democratic' in democratic intelligence oversight has rarely been spelled out. In this paper, we situate questions regarding intelligence oversight within broader debates about the meanings and practices of democracy. We argue that the literature on intelligence oversight has tended to implicitly or explicitly follow liberal and technocratic ideas of democracy, which have limited the understanding of oversight both in academia and in practice. Thus, oversight is mostly understood as an expert, institutional and partially exclusive arrangement that is supposed to strike a balance between individual freedom and collective security with the goal of establishing the legitimacy of, and trust in intelligence work in a national setting. ‘Healthy’ or ‘efficient’ democratic oversight then becomes a matter of technical expertise, non-partisanship, and the ability to guard secrets. By analysing three moments of struggle around what counts as intelligence oversight across Germany, the UK, and the USA, this paper elucidates their democratic stakes. Through a practice-based approach, we argue that oversight takes much more agonistic, contentious, transnational, and public forms. However, these democratic practices reconfiguring oversight remain contested or contained by dominant views on what constitutes legitimate and effective intelligence oversight

X-ray and UV spectroscopy of Cygnus X-1 = HDE226868

Observations are presented of Cygnus X-1 with the solid-state spectrometer on the Einstein Observatory. The X-ray spectra of two intensity dips viewed near superior conjunction did not exhibit increased photoelectric absorption. Rather the data support a model in which an increase in the electron scattering optical depth modifies both the observed spectrum and the intensity. The characteristic temperature of the intervening material is greater than 5 x 10 to the 7th power K. These measurements were in part simultaneous with observations by IUE. The ultra violet spectrum and intensity remained relatively constant during an X-ray intensity dip

Antigiardial activity of novel guanidine compounds

From four focused compound libraries based on the known anticoccidial agent robenidine, 44 compounds total were synthesised and screened for antigiardial activity. All active compounds were counter-screened for antibiotic and cytotoxic action. Of the analogues examined, 21 displayed IC50<5 μM, seven with IC50<1.0 μM. Most active were 2,2′-bis{[4-(trifluoromethoxy)phenyl]methylene}carbonimidic dihydrazide hydrochloride (30), 2,2′-bis{[4-(trifluoromethylsulfanyl)phenyl]methylene}carbonimidic dihydrazide hydrochloride (32), and 2,2′-bis[(2-bromo-4,5-dimethoxyphenyl)methylene]carbonimidic dihydrazide hydrochloride (41) with IC50=0.2 μM. The maximal observed activity was a 5 h IC50 value of 0.2 μM for 41. The clinically used metronidazole was inactive at this timepoint at a concentration of 25 μM. Robenidine off-target effects at bacteria and cell line toxicity were removed. Analogue 41 was well tolerated in mice treated orally (100 mg/kg). Following 5 h treatment with 41, no Giardia regrowth was noted after 48 h

The true cost of hidden waiting times for cataract surgery in Australia

Cataract surgery is a safe, effective and common elective procedure in Australia but access is inequitable. True waiting times for cataract care are undisclosed or inconsistently reported by governments. Estimates of true waiting times range from 4 to 30 months and have been extended during the coronavirus disease 2019 (COVID-19) pandemic. Comparative analysis revealed that reducing waiting periods from 12 to 3 months would result in estimated public health system cost savings of $6.6 million by preventing 50 679 falls. Investment in public cataract services to address current unmet needs would prevent avoidable vision impairment and associated negative consequences

Draft genome sequence of Neurospora crassa strain FGSC 73

Citation: Baker, S. E., Schackwitz, W., Lipzen, A., Martin, J., Haridas, S., LaButti, K., . . . McCluskey, K. (2016). Draft genome sequence of Neurospora crassa strain FGSC 73. Genome Announcements, 3(2). doi:10.1128/genomeA.00074-15Citation: Baker, S., Schackwitz, W., Lipzen, A., . . . McCluskey, K. (2015). Draft Genome Sequence of Neurospora crassa Strain FGSC 73. Genome Announcements, 3(2), e00074-15. https://doi.org/10.1128/genomeA.00074-15We report the elucidation of the complete genome of the Neurospora crassa (Shear and Dodge) strain FGSC 73, a mat-a, trp-3 mutant strain. The genome sequence around the idiotypic mating type locus represents the only publicly available sequence for a mat-a strain. 40.42 Megabases are assembled into 358 scaffolds carrying 11,978 gene models. © 2015 Baker et al

Oxygen Recovery Kinetics in the Forearm Flexors of Multiple Ability Groups of Rock Climbers

Fryer, SM, Stoner, L, Dickson, TG, Draper, SB, McCluskey, MJ, Hughes, JD, How, SC, and Draper, N. Oxygen recovery kinetics in the forearm flexors of multiple ability groups of rock climbers. J Strength Cond Res 29(6): 1633-1639, 2015-The purpose of this study was to determine muscle tissue oxidative capacity and recovery in intermediate, advanced, and elite rock climbers. Forty-four male participants performed (a) sustained and (b) intermittent contractions at 40% of maximal volitional contraction (MVC) on a sport-specific fingerboard until volitional fatigue. Near-infrared spectroscopy was used to assess muscle tissue oxygenation during both the exercise and the 5-minutes passive recovery period, in the flexor digitorum profundus (FDP) and flexor carpi radialis (FCR). During the sustained contraction only, muscle tissue deoxygenation (O2 debt) in the FDP and FCR was significantly greater in elite climbers compared with the control, intermediate, and advanced groups (FDP: 32 vs. 15, 19, 22%; FCR: 19 vs. 11, 8, 15%, respectively). However, elite climbers had a significantly quicker time to half recovery (T1/2) than the control and intermediate groups in the FDP (8 vs. 95 and 47 seconds, respectively) and the FCR (7 vs. 30 and 97 seconds, respectively) because the O2% recovered per second being significantly greater (FDP: 4.2 vs. 0.7 and 0.3; FCR: 4.8 vs. 0.1 and 0.2, respectively). Furthermore, during the intermittent contraction, T1/2 in elite climbers was significantly quicker compared with the control and intermediate groups in the FDP (8 vs. 93 and 83 seconds, respectively) and FCR (16 vs. 76 and 50 seconds, respectively). Consequently, lower-level climbers should focus training on specific intermittent fatigue protocols. Competition or elite climbers should make use of appropriate rests on route to aid recovery and increase the chances of reaching the next hold