Tatárjuharos tölgyesek (Aceri tatarici­-Quercetum pubescentis-roboris Zólyomi 1957) a Mezőföldön

Dolgozatunkban húsz mezőföldi tölgyes erdőmaradványon elvégzett összehasonlító fitocö- nológiai elemzés eredményeit mutatjuk be. A vizsgált állományok számos sajátossága, így az erdő különböző fényviszonyokat eredményező belső struktúrája, a sztyepfajok (Festucion rupicolae) és a mezofil erdei ele - mek (Fagetalia) együttes előfordulása, valamint a szárazgyepekre (Festuco-Brometea), illetve a száraz tölgye - sekre (Quercetea pubescentis-petraeae) jellemző fajok tekintélyes aránya, nagymértékű egyezést mutatott a Magyarországról leírt sztyeperdők ( Aceri tatarici-Quercetum pubescentis-roboris ) megfelelő paramétereivel. Az európai és eurázsiai flóraelemek mellett az állományokban jelentős arányban vannak jelen szubmediterrán, pontuszi és kontinentális elemek is. Mindezek alapján megállapítottuk, hogy a vizsgált állományok az erdőssz - tyep szubmediterrán erdőtípusát képviselik

Use of r(+)-n-propargyl-1-aminoindan to treat or prevent hearing loss

A method of treating or inhibiting hearing loss in a mammalian subject, comprising administering to the subject an amount of R(+)-N-propargyl-1-aminoindan or pharmaceutically acceptable salt thereof effective to treat or inhibit the hearing loss in the subject

Imaging high-resolution structure of GFP-expressing neurons in neocortex in vivo

To detect subtle changes in neuronal morphology in response to changes in experience, one must image neurons at high resolution in vivo over time scales of minutes to days. We accomplished this by infecting postmitotic neurons in rat and mouse barrel cortex with a Sindbis virus carrying the gene for enhanced green fluorescent protein. Visualized with 2-photon excitation laser scanning microscopy, infected neurons showed bright fluorescence that was distributed homogeneously throughout the cell, including axonal and dendritic arbors. Single dendritic spines could routinely be resolved and their morphological dynamics visualized. Viral infection and imaging were achieved throughout postnatal development up to early adulthood (P 8-30), although the viral efficiency of infection decreased with age. This relatively noninvasive method for fluorescent labeling and imaging of neurons allows the study of morphological dynamics of neocortical neurons and their circuits in vivo

In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography

The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor-DNA interfaces, and modulate gene expression pathways in cell culture experiments. The 18F-radiolabeled polyamides were prepared by oxime ligation between 4-[18F]-fluorobenzaldehyde and a hydroxylamine moiety at the polyamide C terminus. Small animal PET imaging of radiolabeled polyamides administered to mice revealed distinct differences in the biodistribution of a 5-ring β-linked polyamide versus an 8-ring hairpin, which exhibited better overall bioavailability. In vivo imaging of pyrrole-imidazole polyamides by PET is a minimum first step toward the translation of polyamide-based gene regulation from cell culture to small animal studies