THE PHARMACOKINETICS OF N-[C-14-FORMYL]-LEUROSINE IN HUMANS

N-Formyl-leurosine labeled with 14C in the formyl group was administered to six patients with malignant disease, and the pharmacokinetic behavior of the drug was determined. Chromatographic studies on plasma showed the presence of unchanged drug and 7 metabolites. No metabolites were found in the urine. The plasma decay curve of the unchanged drug was biphasic with half-life values of t1 2α = 18.6 min and t1 2β = 4.28 hr. Within 72 hr only 30-40% of the radioactivity could be recovered in urine and feces in 5 patients. One patient consumed laxatives during the treatment. In this case 95% of the 14C-dose was recovered. The contribution made by fecal elimination was 80%. © 1981

Radioecological assessments of the Iodine working group of IAEA's EMRAS programme: Presentation of input data and analysis of results of the prague scenario

In 2003 IAEA launched the EMRAS Programme aiming at evaluating the predictive power of radiological models. The programme continued work of previous international radioecological modelling programmes and comprised several working groups focusing on different aspects of environmental modelling. The Iodine Working Group reassessed the impact of the release of 131I during the Chernobyl accident with the aim of comparing model predictions with environmental data and inter-comparing the model predictions. Measurement data and detailed geographic and demographic descriptions were available for three regions: Plavsk, Warsaw and Prague. As for the Prague Scenario, milk supply regions of three big dairies were chosen for the model validation. Apart from geographic, demographic and agricultural descriptions (e.g. gathering regions of the dairies, feeding regime), the modellers were provided with information on the weather conditions and measurement data of iodine contamination. The most important peculiarities of Prague Scenario were keeping milk cattle in sheds and a special feeding regime during May 1986. The modellers were asked to assess the 131I content in the thyroid of the local population and the resulting dose. The assessments were compared with measurement data. The results of these model calculations and their comparison with experimental data are presented

Validation of environmental transfer models and assessment of the effectiveness of countermeasures using data on 131I releases from Chernobyl

The studies undertaken by the 131I Working Group, part of the International Atomic Energy Agency's EMRAS (Environmental Modelling for Radiation Safety) programme, were focused primarily on evaluating the predictive capability of environmental models. Particular emphasis was placed on applying models to evaluate the effectiveness of countermeasures. © 2008 IAEA