Pigment Epithelium-Derived Factor – An Angiostatic Factor with a Broader Function in Melanoma

Capítulo 8: Open Access.Supported by grants Ministerio de Educacion y Ciencia SAF2007-62292 and SAF2010-19256 to BJ. AFB has been supported by a CSIC-JAE fellowship and JLO by a SAF2007-62292 contract.Peer Reviewe

Conference Proceedings of the 1st Conference in Business Research and Management

This edited book contains the conference proceedings of the “1st Conference in Business Research and Management”, organized by the University of Castilla – La Mancha and the University of Rome “Tor Vergata”. The Conference took place on May 26th and 27th 2022, at the University of Castilla – La Mancha in Toledo. The aim of the Conference was to discuss the most important managerial and organizational implications of the pandemic and the future challenges that public and private organizations will have to face in the coming years, the so–called “New Normal”. The volume contains all the 49 extended abstracts presented during the Conference

Autoconcepto académico y toma de decisiones en el alumnado de bachillerato

ABSTRACTThis article shows the relationship between academic self‐concept, perceived academic self‐concept, and decision making in Secondary Education. 454 students take part in this research. The instrument used in this article was a questionnaire containing an adaptation “Self‐Concept of Ability General Scale”, “Perceived Parental Evaluation of Ability Scale” and “Perceived Teacher’s Evaluations of Ability Scale” from Brookover, Erickson y Joiner (1967). The statistical analysis shows high correlations between analysed variables. The students who choose the University: a) they value their academic years; b) they become aware a good impression about their parents and teachers and about their high school achievement; c) they adopt a more responsible attitude towards their future studies, from those who choose another option. The results provide interesting suggestions to generate intervention strategies in the academic and working decision making process.RESUMEN Este trabajo analiza las relaciones entre el autoconcepto académico y el autoconcepto académico percibido con la toma de decisiones de los alumnos de Bachillerato. En la investigación participaron 454 alumnos. El instrumento utilizado fue un cuestionario en el que se incluyó una adaptación para el Bachillerato de las escalas “Qué Opinas de ti Mismo”, “Qué Opinan Tus Padres de Ti” y “Qué Opinan Tus profesores de Ti” de Brookover, Erickson y Joiner (1967). Los análisis estadísticos muestran altas correlaciones entre las variables analizadas. Los alumnos que optan por la Universidad: a) valoran más favorablemente su faceta académica; b) perciben en sus padres y en el profesorado una valoración más positiva de su rendimiento en Bachillerato; c) adoptan una actitud más responsable hacia sus estudios que quienes eligen otra opción. Los resultados aportan interesantes sugerencias para generar estrategias de intervención en los procesos de toma de decisiones académico-laborales. ABSTRACT This article shows the relationship between academic self‐concept, perceived academic self‐concept, and decision making in Secondary Education. 454 students take part in this research. The instrument used in this article was a questionnaire containing an adaptation “Self‐Concept of Ability General Scale”, “Perceived Parental Evaluation of Ability Scale” and “Perceived Teacher’s Evaluations of Ability Scale” from Brookover, Erickson y Joiner (1967). The statistical analysis shows high correlations between analysed variables. The students who choose the University: a) they value their academic years; b) they become aware a good impression about their parents and teachers and about their high school achievement; c) they adopt a more responsible attitude towards their future studies, from those who choose another option. The results provide interesting suggestions to generate intervention strategies in the academic and working decision making process

Measurement of the production cross section for W-bosons in association with jets in pp collisions at s=7 TeV with the ATLAS detector

This Letter reports on a first measurement of the inclusive W + jets cross section in proton-proton collisions at a centre-of-mass energy of 7 TeV at the LHC, with the ATLAS detector. Cross sections, in both the electron and muon decay modes of the W-boson, are presented as a function of jet multiplicity and of the transverse momentum of the leading and next-to-leading jets in the event. Measurements are also presented of the ratio of cross sections sigma (W + >= n)/sigma(W + >= n - 1) for inclusive jet multiplicities n = 1-4. The results, based on an integrated luminosity of 1.3 pb(-1), have been corrected for all known detector effects and are quoted in a limited and well-defined range of jet and lepton kinematics. The measured cross sections are compared to particle-level predictions based on perturbative QCD. Next-to-leading order calculations, studied here for n <= 2, are found in good agreement with the data. Leading-order multiparton event generators, normalized to the NNLO total cross section, describe the data well for all measured jet multiplicitie

Hidden Gems on a Ring: Infant Massive Clusters and Their Formation Timeline Unveiled by ALMA, HST, and JWST in NGC 3351

We use 0.1 '' observations from the Atacama Large Millimeter Array (ALMA), Hubble Space Telescope (HST), and JWST to study young massive clusters (YMCs) in their embedded "infant" phase across the central starburst ring in NGC 3351. Our new ALMA data reveal 18 bright and compact (sub-)millimeter continuum sources, of which 8 have counterparts in JWST images and only 6 have counterparts in HST images. Based on the ALMA continuum and molecular line data, as well as ancillary measurements for the HST and JWST counterparts, we identify 14 sources as infant star clusters with high stellar and/or gas masses (similar to 105 M circle dot), small radii (less than or similar to 5 pc), large escape velocities (6-10 km s-1), and short freefall times (0.5-1 Myr). Their multiwavelength properties motivate us to divide them into four categories, likely corresponding to four evolutionary stages from starless clumps to exposed H ii region-cluster complexes. Leveraging age estimates for HST-identified clusters in the same region, we infer an evolutionary timeline, ranging from similar to 1-2 Myr before cluster formation as starless clumps, to similar to 4-6 Myr after as exposed H ii region-cluster complexes. Finally, we show that the YMCs make up a substantial fraction of recent star formation across the ring, exhibit a nonuniform azimuthal distribution without a very coherent evolutionary trend along the ring, and are capable of driving large-scale gas outflows

Open Access Solutions for Biodiversity Journals: Don’t Replace One Problem with Another

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PHANGS-JWST First Results: Multiwavelength View of Feedback-driven Bubbles (the Phantom Voids) across NGC 628

We present a high-resolution view of bubbles within the Phantom Galaxy (NGC 628), a nearby (similar to 10 Mpc), star-forming (similar to 2 M (circle dot) yr(-1)), face-on (i similar to 9 degrees) grand-design spiral galaxy. With new data obtained as part of the Physics at High Angular resolution in Nearby GalaxieS (PHANGS)-JWST treasury program, we perform a detailed case study of two regions of interest, one of which contains the largest and most prominent bubble in the galaxy (the Phantom Void, over 1 kpc in diameter), and the other being a smaller region that may be the precursor to such a large bubble (the Precursor Phantom Void). When comparing to matched-resolution H alpha observations from the Hubble Space Telescope, we see that the ionized gas is brightest in the shells of both bubbles, and is coincident with the youngest (similar to 1 Myr) and most massive (similar to 10(5) M (circle dot)) stellar associations. We also find an older generation (similar to 20 Myr) of stellar associations is present within the bubble of the Phantom Void. From our kinematic analysis of the H I, H-2 (CO), and H ii gas across the Phantom Void, we infer a high expansion speed of around 15 to 50 km s(-1). The large size and high expansion speed of the Phantom Void suggest that the driving mechanism is sustained stellar feedback due to multiple mechanisms, where early feedback first cleared a bubble (as we observe now in the Precursor Phantom Void), and since then supernovae have been exploding within the cavity and have accelerated the shell. Finally, comparison to simulations shows a striking resemblance to our JWST observations, and suggests that such large-scale, stellar-feedback-driven bubbles should be common within other galaxies

PHANGS-JWST First Results: A Statistical View on Bubble Evolution in NGC 628

The first JWST observations of nearby galaxies have unveiled a rich population of bubbles that trace the stellar-feedback mechanisms responsible for their creation. Studying these bubbles therefore allows us to chart the interaction between stellar feedback and the interstellar medium, and the larger galactic flows needed to regulate star formation processes globally. We present the first catalog of bubbles in NGC 628, visually identified using Mid-Infrared Instrument F770W Physics at High Angular resolution in Nearby GalaxieS (PHANGS)-JWST observations, and use them to statistically evaluate bubble characteristics. We classify 1694 structures as bubbles with radii between 6 and 552 pc. Of these, 31% contain at least one smaller bubble at their edge, indicating that previous generations of star formation have a local impact on where new stars form. On large scales, most bubbles lie near a spiral arm, and their radii increase downstream compared to upstream. Furthermore, bubbles are elongated in a similar direction to the spiral-arm ridgeline. These azimuthal trends demonstrate that star formation is intimately connected to the spiral-arm passage. Finally, the bubble size distribution follows a power law of index p = −2.2 ± 0.1, which is slightly shallower than the theoretical value by 1-3.5σ that did not include bubble mergers. The fraction of bubbles identified within the shells of larger bubbles suggests that bubble merging is a common process. Our analysis therefore allows us to quantify the number of star-forming regions that are influenced by an earlier generation, and the role feedback processes have in setting the global star formation rate. With the full PHANGS-JWST sample, we can do this for more galaxies

The PHANGS-JWST Treasury Survey: Star Formation, Feedback, and Dust Physics at High Angular Resolution in Nearby GalaxieS

The PHANGS collaboration has been building a reference data set for the multiscale, multiphase study of star formation and the interstellar medium (ISM) in nearby galaxies. With the successful launch and commissioning of JWST, we can now obtain high-resolution infrared imaging to probe the youngest stellar populations and dust emission on the scales of star clusters and molecular clouds (∼5-50 pc). In Cycle 1, PHANGS is conducting an eight-band imaging survey from 2 to 21 μm of 19 nearby spiral galaxies. Optical integral field spectroscopy, CO(2-1) mapping, and UV-optical imaging for all 19 galaxies have been obtained through large programs with ALMA, VLT-MUSE, and Hubble. PHANGS-JWST enables a full inventory of star formation, accurate measurement of the mass and age of star clusters, identification of the youngest embedded stellar populations, and characterization of the physical state of small dust grains. When combined with Hubble catalogs of ∼10,000 star clusters, MUSE spectroscopic mapping of ∼20,000 H ii regions, and ∼12,000 ALMA-identified molecular clouds, it becomes possible to measure the timescales and efficiencies of the earliest phases of star formation and feedback, build an empirical model of the dependence of small dust grain properties on local ISM conditions, and test our understanding of how dust-reprocessed starlight traces star formation activity, all across a diversity of galactic environments. Here we describe the PHANGS-JWST Treasury survey, present the remarkable imaging obtained in the first few months of science operations, and provide context for the initial results presented in the first series of PHANGS-JWST publications