General study of superscaling in quasielastic (e,e′)(e,e') and (ν,μ)(\nu,\mu) reactions using the relativistic impulse approximation

The phenomenon of superscaling for quasielastic lepton induced reactions at energies of a few GeV is investigated within the framework of the relativistic impulse approximation. A global analysis of quasielastic inclusive electron and charged-current neutrino scattering reactions on nuclei is presented. Scaling and superscaling properties are shown to emerge from both types of processes. The crucial role played by final state interactions is evaluated by using different approaches. The asymmetric shape presented by the experimental scaling function, with a long tail in the region of positive values of the scaling variable, is reproduced when the interaction in the final state between the knockout nucleon and the residual nucleus is described within the relativistic mean field approach. The impact of gauge ambiguities and off-shell effects in the scaling function is also analyzed.Comment: 34 pages, 14 figures, accepted in Phys. Rev. C. Section II has been shortene

Well-Posedness And Accuracy Of The Ensemble Kalman Filter In Discrete And Continuous Time

The ensemble Kalman filter (EnKF) is a method for combining a dynamical model with data in a sequential fashion. Despite its widespread use, there has been little analysis of its theoretical properties. Many of the algorithmic innovations associated with the filter, which are required to make a useable algorithm in practice, are derived in an ad hoc fashion. The aim of this paper is to initiate the development of a systematic analysis of the EnKF, in particular to do so in the small ensemble size limit. The perspective is to view the method as a state estimator, and not as an algorithm which approximates the true filtering distribution. The perturbed observation version of the algorithm is studied, without and with variance inflation. Without variance inflation well-posedness of the filter is established; with variance inflation accuracy of the filter, with resepct to the true signal underlying the data, is established. The algorithm is considered in discrete time, and also for a continuous time limit arising when observations are frequent and subject to large noise. The underlying dynamical model, and assumptions about it, is sufficiently general to include the Lorenz '63 and '96 models, together with the incompressible Navier-Stokes equation on a two-dimensional torus. The analysis is limited to the case of complete observation of the signal with additive white noise. Numerical results are presented for the Navier-Stokes equation on a two-dimensional torus for both complete and partial observations of the signal with additive white noise

Tildrakizumab in the treatment of psoriasis: latest evidence and place in therapy.

Psoriasis is a chronic inflammatory disorder that is clinically characterized by scaly cutaneous plaques. New evidence suggests that dysregulation of interleukin (IL)-23, a key cytokine in the T-helper-17 pathway, plays a vital role in the development of psoriatic systemic inflammation. The novel biologic medication tildrakizumab is among the first drugs with specific action against IL-23 that has recently been approved by the United States Food and Drug Administration and the European Medicines Agency for moderate-to-severe psoriasis. Tildrakizumab has been shown in large randomized controlled trials to be effective in improving skin manifestations as well as enhancing quality of life outcomes in patients with psoriasis. Its simple dosing, prolonged duration of action, and mild adverse event profile make it a practical option for patients; however, only a small number of trials have investigated the clinical effectiveness of tildrakizumab, and long-term data regarding the drug's efficacy and safety are currently limited. Hence, further research is needed to better understand the risks and benefits of tildrakizumab. This review summarizes and analyzes phase I, phase II, and phase III clinical trials that investigate the mechanism, pharmacokinetics, efficacy, and safety of tildrakizumab. It also identifies areas in which additional studies are warranted to further elucidate the advantages of tildrakizumab over other biologic therapies

Virial Masses of Black Holes from Single Epoch Spectra of AGN

We describe the general problem of estimating black hole masses of AGN by calculating the conditional probability distribution of M_BH given some set of observables. Special attention is given to the case where one uses the AGN continuum luminosity and emission line widths to estimate M_BH, and we outline how to set up the conditional probability distribution of M_BH given the observed luminosity, line width, and redshift. We show how to combine the broad line estimates of M_BH with information from an intrinsic correlation between M_BH and L, and from the intrinsic distribution of M_BH, in a manner that improves the estimates of M_BH. Simulation was used to assess how the distribution of M_BH inferred from the broad line mass estimates differs from the intrinsic distribution, and we find that this can lead to an inferred distribution that is too broad. We use these results and a sample of 25 sources that have recent reverberation mapping estimates of AGN black hole masses to investigate the effectiveness of using the C IV emission line to estimate M_BH and to indirectly probe the C IV region size--luminosity (R--L) relationship. We estimated M_BH from both C IV and H-Beta for a sample of 100 sources, including new spectra of 29 quasars. We find that the two emission lines give consistent estimates if one assumes R \propto L^{1/2}_{UV} for both lines.Comment: 38 pages, 6 figures, accepted by Ap

Wide energy-window view on the density of states and hole mobility of poly(p-phenylene vinylene)

Using an electrochemically gated transistor, we achieved controlled and reversible doping of poly(p-phenylene vinylene) in a large concentration range. Our data open a wide energy-window view on the density of states (DOS) and show, for the first time, that the core of the DOS function is Gaussian, while the low-energy tail has a more complex structure. The hole mobility increases by more than four orders of magnitude when the electrochemical potential is scanned through the DOS.Comment: 4 pages, 4 figure

Prompt Electromagnetic Transients from Binary Black Hole Mergers

Binary black hole (BBH) mergers provide a prime source for current and future interferometric GW observatories. Massive BBH mergers may often take place in plasma-rich environments, leading to the exciting possibility of a concurrent electromagnetic (EM) signal observable by traditional astronomical facilities. However, many critical questions about the generation of such counterparts remain unanswered. We explore mechanisms that may drive EM counterparts with magnetohydrodynamic simulations treating a range of scenarios involving equal-mass black-hole binaries immersed in an initially homogeneous fluid with uniform, orbitally aligned magnetic fields. We find that the time development of Poynting luminosity, which may drive jet-like emissions, is relatively insensitive to aspects of the initial configuration. In particular, over a significant range of initial values, the central magnetic field strength is effectively regulated by the gas flow to yield a Poynting luminosity of $10^{45}-10^{46} \rho_{-13} M_8^2 \, {\rm erg}\,{\rm s}^{-1}$, with BBH mass scaled to $M_8 \equiv M/(10^8 M_{\odot})$ and ambient density $\rho_{-13} \equiv \rho/(10^{-13} \, {\rm g} \, {\rm cm}^{-3})$. We also calculate the direct plasma synchrotron emissions processed through geodesic ray-tracing. Despite lensing effects and dynamics, we find the observed synchrotron flux varies little leading up to merger.Comment: 22 pages, 21 figures; additional reference + clarifying text added to match published versio

The oral microbiome and adverse pregnancy outcomes.

Significant evidence supports an association between periodontal pathogenic bacteria and preterm birth and preeclampsia. The virulence properties assigned to specific oral pathogenic bacteria, for example, Fusobacterium nucleatum, Porphyromonas gingivalis, Filifactor alocis, Campylobacter rectus, and others, render them as potential collaborators in adverse outcomes of pregnancy. Several pathways have been suggested for this association: 1) hematogenous spread (bacteremia) of periodontal pathogens; 2) hematogenous spread of multiple mediators of inflammation that are generated by the host and/or fetal immune response to pathogenic bacteria; and 3) the possibility of oral microbial pathogen transmission, with subsequent colonization, in the vaginal microbiome resulting from sexual practices. As periodontal disease is, for the most part, preventable, the medical and dental public health communities can address intervention strategies to control oral inflammatory disease, lessen the systemic inflammatory burden, and ultimately reduce the potential for adverse pregnancy outcomes. This article reviews the oral, vaginal, and placental microbiomes, considers their potential impact on preterm labor, and the future research needed to confirm or refute this relationship