Interfacial elastic relaxation during the ejection of bi-layered tablets

The predilection of a bi-layered tablet to fail in the interface region after its initial formation in the compaction process reduces its practicality as a choice for controlled release solid drug delivery system. Hence, a fundamental appreciation of the governing mechanism that causes the weakening of the interfacial bonds within the bi-layered tablet is crucial in order to improve the overall bi-layered tablet mechanical integrity. This work has shown that the occurrence of the elastic relaxation in the interface region during the ejection stage of the compaction process decreases with the increase in the bi-layered tablet interface strength. This is believed to be due to the increase in the plastic bonding in the interface region. The tablet diametrical elastic relaxation affects the tablet height elastic relaxation, where the impediment of the tablet height expansion is observed when the interface region experiences a diametrical expansion

Helicity-dependent photoabsorption cross sections on the nucleon

We examine the energy dependence of single-meson photoproduction as it contributes to the Gerasimov-Drell-Hearn (GDH) sum rule. For photon energies above approximately 1 GeV, through the full resonance region, this contribution dominates the proton sum rule integral. Over the same energy region, our single-pion contribution to the neutron sum rule also qualitatively follows a recent set of GDH data. The predicted neutral-pion contribution to the neutron sum rule is nearly zero above 1 GeV in this result. The SAID and Mainz (MAID) results are very different for a number of observables over this energy region.Comment: 7 pages, 5 figur

On the Extraction of Cross Sections for pi0 and eta Photoproduction off Neutrons from Deuteron Data

We discuss the procedure of extracting the photoproduction cross section for neutral pseudoscalar mesons off neutrons from deuteron data. The main statement is that the final-state interaction (FSI) corrections for the proton and neutron target are in general not equal, but for pi0 production there are special cases were they have to be identical and there are large regions in the parameter space of incident photon energy and pion polar angle, \theta^*, where they happen to be quite similar. The corrections for both target nucleons are practically identical for $\pi_0$ production in the energy range of the Delta(1232)3/2+ resonance due to the specific isospin structure of this excitation. Also above the $\Delta$-isobar range large differences between proton and neutron correction factors are only predicted for extreme forward angles ($\theta^*$ < 20 deg), but the results are similar for larger angles. Numerical results for the gp-->pi0p and gn-->pi0n correction factors are discussed. Also the model description for the available data on the differential gd-->pi0pn cross sections are given.Comment: 16 pages, 5 figures; v2 fixed several minor typo

Extracting the photoproduction cross section off the neutron gn-->pi-p from deuteron data with FSI effects

The incoherent pion photoproduction reaction gd-->pi-pp is considered theoretically in a wide energy region Eth =< Eg =< 2700 MeV. The model applied contains the impulse approximation as well as the NN- and piN-FSI amplitudes. The aim of the paper is to study a reliable way for getting the information on elementary gn-->pi-p reaction cross section beyond the impulse approximation for gd-->pi-pp. For the elementary gN-->piN, NN-->NN, and piN-->piN amplitudes, the results of the GW DAC are used. There are no additional theoretical constraints. The calculated cross section dSigma/dOmega(gd->pi-pp) are compared with existing data. The procedure used to extract information on the differential cross section dSigma/dOmega(gn-->pi-p) on the neutron from the deuteron data using the FSI correction factor R is discussed. The calculations for R versus pi-p CM angle \theta_1 of the outgoing pion are performed at different photon-beam energies with kinematical cuts for "quasi-free" process gn-->pi-p. The results show a sizeable FSI effect R \neq 1 from S-wave part of pp-FSI at small angles close to \theta_1 ~ 0: this region narrows as the photon energy increases. At larger angles, the effect is small (|R-1|<<1) and agrees with estimations of FSI in the Glauber approach.Comment: 28 pages, 5 figures, 1 tabl

Ratios of Elastic Scattering of Pions from 3H and 3He

We have measured the elastic-scattering ratios of normalized yields for charged pions from 3H and 3He in the backward hemisphere. At 180 MeV, we completed the angular distribution begun with our earlier measurements, adding six data points in the angular range of 119 deg to 169 deg in the pi-nucleus center of mass. We also measured an excitation function with data points at 142, 180, 220, and 256 MeV incident pion energy at the largest achievable angle for each energy between 160 deg and 170 deg in the pi-nucleus center of mass. This excitation function corresponds to the energies of our forward-hemisphere studies. The data, taken as a whole, show an apparent role reversal of the two charge-symmetric ratios r1 and r2 in the backward hemisphere. Also, for data > 100 deg we observe a strong dependence on the four-momentum transfer squared (-t) for all of the ratios regardless of pion energy or scattering angle, and we find that the superratio R data match very well with calculations based on the forward-hemisphere data that predicts the value of the difference between the even-nucleon radii of 3H and 3He. Comparisons are also made with recent calculations incorporating different wave functions and double scattering models.Comment: RevTex 8pages, 12 figure file

Coherent photoproduction of pi(+) from He-3

We have measured the differential cross section for the gamma He-3 -\u3e pi(+)t reaction. This reaction was studied using the Continuous Electron Beam Accelerator Facility (CEBAF) Large Acceptance Spectrometer (CLAS) at Jefferson Lab. Real photons produced with the Hall-B bremsstrahlung tagging system in the energy range from 0.50 to 1.55 GeV were incident on a cryogenic liquid He-3 target. The differential cross sections for the gamma He-3 -\u3e pi(+)t reaction were measured as a function of photon-beam energy and pion-scattering angle. Theoretical predictions to date cannot explain the large cross sections except at backward angles, showing that additional components must be added to the model

Effects of the Selective Serotonin Reuptake Inhibitor Fluoxetine on Counterregulatory Responses to Hypoglycemia in Individuals With Type 1 Diabetes

OBJECTIVE—Previous work has demonstrated that chronic administration of the serotonin reuptake inhibitor (SSRI) fluoxetine augments counterregulatory responses to hypoglycemia in healthy humans. However, virtually no information exists regarding the effects of fluoxetine on integrated physiological counterregulatory responses during hypoglycemia in type 1 diabetes. Therefore, the specific aim of this study was to test the hypothesis that 6-week use of the SSRI fluoxetine would amplify autonomic nervous system (ANS) counterregulatory responses to hypoglycemia in individuals with type 1 diabetes

A measurement of the differential cross section for the two-body photodisintegration of 3He at theta_LAB = 90deg using tagged photons in the energy range 14 -- 31 MeV

The two-body photodisintegration of 3He has been investigated using tagged photons with energies from 14 -- 31 MeV at MAX-lab in Lund, Sweden. The two-body breakup channel was unambiguously identified by the (nonsimultaneous) detection of both protons and deuterons. This approach was made feasible by the over-determined kinematic situation afforded by the tagged-photon technique. Proton- and deuteron-energy spectra were measured using four silicon surface-barrier detector telescopes located at a laboratory angle of 90deg with respect to the incident photon-beam direction. Average statistical and systematic uncertainties of 5.7% and 6.6% in the differential cross section were obtained for 11 photon-energy bins with an average width of 1.2 MeV. The results are compared to previous experimental data measured at comparable photon energies as well as to the results of two recent Faddeev calculations which employ realistic potential models and take into account three-nucleon forces and final-state interactions. Both the accuracy and precision of the present data are improved over the previous measurements. The data are in good agreement with most of the previous results, and favor the inclusion of three-nucleon forces in the calculations.Comment: 12 pages, 13 figures; further Referee comments addresse

Charge-Symmetry Violation in Pion Scattering from Three-Body Nuclei

We discuss the experimental and theoretical status of charge-symmetry violation (CSV) in the elastic scattering of pi+ and pi- on 3H and 3He. Analysis of the experimental data for the ratios r1, r2, and R at Tpi = 142, 180, 220, and 256 MeV provides evidence for the presence of CSV. We describe pion scattering from the three-nucleon system in terms of single- and double-scattering amplitudes. External and internal Coulomb interactions as well as the Delta-mass splitting are taken into account as sources of CSV. Reasonable agreement between our theoretical calculations and the experimental data is obtained for Tpi = 180, 220, and 256 MeV. For these energies, it is found that the Delta-mass splitting and the internal Coulomb interaction are the most important contributions for CSV in the three-nucleon system. The CSV effects are rather sensitive to the choice of pion-nuclear scattering mechanisms, but at the same time, our theoretical predictions are much less sensitive to the choice of the nuclear wave function. It is found, however, that data for r2 and R at Tpi = 142 MeV do not agree with the predictions of our model, which may indicate that there are additional mechanisms for CSV which are important only at lower energies.Comment: 26 pages of RevTeX, 16 postscript figure

Pre-Congestion Notification marking

Pre-Congestion Notification (PCN) builds on the concepts of RFC 3168, "The addition of Explicit Congestion Notification to IP". However, Pre-Congestion Notification aims at providing notification before any congestion actually occurs. Pre-Congestion Notification is applied to real-time flows (such as voice, video and multimedia streaming) in DiffServ networks. As described in [CL-DEPLOY], it enables "pre" congestion control through two procedures, flow admission control and flow pre-emption. The draft proposes algorithms that determine when a PCN-enabled router writes Admission Marking and Pre-emption Marking in a packet header, depending on the traffic level. The draft also proposes how to encode these markings. We present simulation results with PCN working in an edge-to-edge scenario using the marking algorithms described. Other marking algorithms will be investigated in the future