A Summer Range Shelter

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Accretion mode changes in Centaurus X-3

We report here discovery of the existence of two different accretion modes in the high mass X-ray binary pulsar Cen X-3 during its high states. The multiband X-ray light curves of Cen X-3 lasting for more than 3400 days obtained with the All Sky Monitor (ASM) onboard the Rossi X-ray Timing Explorer (RXTE) shows many episodes of high and low X-ray intensities. The high intensity phases last between a few to upto 110 days and the separation between two high intensity phases also varies widely. One remarkable feature deduced from the RXTE-ASM light curves is that during these high intensity phases, Cen X-3 manifests in two very distinct spectral states. When the source makes a transition from the low intensity phase to the high intensity phase, it adopts one of these two spectral states and during the entire high intensity phase remains in that particular spectral state. During December 2000 to April 2004, all the high intensity episodes showed a hardness ratio which is significantly larger than the same during all the high states prior to and subsequent to this period. It is also found that most of the soft outbursts reach a nearly constant peak flux in the 5--12 keV band. For comparison, similar analysis was carried out on the long term X-ray light curves of three other X-ray binary pulsars Her X-1, Vela X-1, and SMC X-1. Results obtained with these sources are also presented here and we found that none of the other sources show such a behaviour. From these observations, we suggest that Cen X-3 has two different accretion modes and in the course of nine years it has exhibited two switch overs between these.Comment: 5 pages, 5 postscript figures, accepted for publication in Astronomy and Astrophysics Letter

Top-Quark Mass and Bottom-Quark Decay

The possibility of a long B-meson lifetime is explored, in which case the weak mixing angles θ_2 and θ_3 are quite small. This allows the derivation of a lower bound on the top-quark mass as a function of the B-meson lifetime, by comparison of the short-distance prediction for the CP-nonconservation parameter ε with its experimental value. The bound is significant for τ_B>4×10^(-13) s

Determination of transmitter function by neuronal activity

The role of neuronal activity in the determination of transmitter function was studied in cultures of dissociated sympathetic neurons from newborn rat superior cervical ganglia. Cholinergic and adrenergic differentiation were assayed by incubating the cultures with radioactive choline and tyrosine and determining the rate of synthesis and accumulation of labelled acetylcholine and catecholamines. As in previous studies, pure neuronal cultures grown in control medium displayed much lower ratios of acetylcholine synthesis to catecholamine synthesis than did sister cultures grown in medium previously conditioned by incubation on appropriate nonneuronal cells (conditioned medium). However, here we report that neurons treated with the depolarizing agents elevated K+ or veratridine, or stimulated directly with electrical current, either before or during application of conditioned medium, displayed up to 300-fold lower acetylcholine/catecholamine ratios than they would have without depolarization, and thus remained primarily adrenergic. Elevated K+ and veratridine produced this effect on cholinergic differentiation without significantly altering neuronal survival. Because depolarization causes Ca2+ entry in a number of cell types, the effects of several Ca2+ agonists and antagonists were investigated. In the presence of the Ca2+ antagonists D600 or Mg2+, K+ did not prevent the induction of cholinergic properties by conditioned medium. Thus depolarization, either steady or accompanying activity, is one of the factors determining whether cultured sympathetic neurons become adrenergic or cholinergic, and this effect may be mediated by Ca2+

Probability for Primordial Black Holes in Multidimensional Universe with Nonlinear Scalar Curvature Terms

We investigate multi-dimensional universe with nonlinear scalar curvature terms to evaluate the probability of creation of primordial black holes. For this we obtain Euclidean instanton solution in two different topologies: (a) $S^{D-1}$ - topology which does not accommodate primordial black holes and (b) $S^1\times S^{D-2}$-topology which accommodates a pair of black holes. The probability for quantum creation of an inflationary universe with a pair of black holes has been evaluated assuming a gravitational action which is described by a polynomial function of scalar curvature with or without a cosmological constant ($\Lambda$) using the framework of semiclassical approximation of Hartle-Hawking boundary conditions. We discuss here a class of new gravitational instantons solution in the $R^4$-theory which are relevant for cosmological model building.Comment: 18 pages, no figure. accepted in Phys. Rev.

A Complex Stereochemical Relay Approach To The Antimalarial Alkaloid Ocimicide A1. Evidence For A Structural Revision

Ocimicide A1 (1) and the semisynthetic derivative ocimicide A2 (2) are highly potent antimalarial agents efficacious against chloroquine-sensitive and -resistant Plasmodium falciparum strains with IC50 values in the nanomolar and picomolar range, respectively. Members of this family have demonstrated radical cure in rhesus monkeys, without detectable toxicity, but their structure–function relationships and mechanism of action are unknown. Herein we describe a twelve-step synthesis of an advanced N-acylated pentacyclic precursor to the proposed structure of 1 (11% overall yield). Instability and poor P. falciparum growth inhibition of the corresponding free donor–acceptor cyclopropylamine, and large discrepancies between reported and both experimental and DFT-calculated 13C chemical shifts and coupling constants, suggest that substantial revision of the proposed structures may be necessary