The Script Work in the Complex Object of Copyrights

In article the questions connected with features of the civil mode of the scenario work as a part of difficult objects of author's rights, such as audiovisual works are investigated (movies, film formats and others). The author in detail considers questions of concepts of the scenario work and a difficult object of author's rights. At the same time the special-purpose character of creation of the scenario work as object of an author's right, namely, for use as a part of difficult objects of author's rights reveals, the interconditionality of concepts, existence of two-level system of author's rights concerning a difficult object, namely, the rights for a difficult object, and the rights to results of intellectual activity which were used during creation of a difficult intellectual property item is proved

Copyright para o cenário de trabalho na Rússia: questões práticas

This article is devoted to litigation in the field of intellectual rights on scenario works in Russia, as well as to the legislative basis of intellectual property objects. The most important features of the work scenario as an object of copyright are considered. The concept of this is defined, examples of judicial practice in Russia related to the protection of work scenarios are given. The spectrum of civil-law ways of protecting these rights is analyzed in case of their violation or contestation by third parties. The issue of the presence or absence of discretionary powers of courts in determining the amount of compensation for protecting the violated exclusive right to a work scenario is under consideration.Este artículo está dedicado al litigio en el campo de los derechos intelectuales en escenarios de trabajo en Rusia, así como a la base legislativa de los objetos de propiedad intelectual. Se consideran las características más importantes del escenario de trabajo como objeto de derecho de autor. Se define el concepto del trabajo de escenarios, se dan ejemplos de prácticas judiciales en Rusia relacionadas con la protección de las obras de escenarios. El espectro de las formas de protección civil de estos derechos se analiza en caso de violación o impugnación por parte de terceros. Se está considerando la cuestión de la presencia o ausencia de facultades discrecionales de los tribunales para determinar el monto de la indemnización por la protección del derecho exclusivo violado a un trabajo de escenario.Este artigo é dedicado ao litígio no campo dos direitos intelectuais em cenários de trabalho na Rússia, bem como à base legislativa de objetos de propriedade intelectual. As características mais importantes do cenário de trabalho são consideradas objeto de direitos autorais. O conceito de trabalho de cenário é definido, exemplos de práticas judiciais na Rússia relacionadas à proteção de obras de cenário são dadas. O espectro de formas de proteção civil desses direitos é analisado em caso de violação ou objeção de terceiros. A questão da presença ou ausência de poderes discricionários dos tribunais está sendo considerada para determinar o montante da compensação pela proteção do direito exclusivo violado a um trabalho de cenário

Chitosan/Poly(2-ethyl-2-oxazoline) films with ciprofloxacin for application in vaginal drug delivery

Chitosan (CHI) and chitosan/poly(2-ethyl-2-oxazoline) (CHI/POZ)-based films were prepared by casting from aqueous solutions of polymer blends with different compositions. Ciprofloxacin was used as a model drug in these formulations. The weight, thickness, folding endurance and transparency of blend films were measured and characterised. All films had a uniform thickness (0.06 ± 0.01 mm) and exhibited sufficient flexibility. The surface pHs of films ranged from 3.76 ± 0.49 to 4.14 ± 0.32, which is within the pH range suitable for vaginal applications. The cumulative release of the drug from the films in experiments in vitro was found to be 42 ± 2% and 56 ± 1% for pure CHI and CHI/POZ (40:60) films, respectively. Drug-free chitosan/poly(2-ethyl-2-oxazoline) films showed weak antimicrobial activity against Escherichia coli. Drug-loaded CHI and CHI/POZ films showed good antimicrobial properties against both Gram-positive Staphylococcus aureus and Gram-negative bacteria Escherichia coli. Mucoadhesive properties of these films with respect to freshly excised sheep vaginal mucosa were evaluated using a tensile method. It was established that all films were mucoadhesive, but an increase in POZ content in the blend resulted in a gradual reduction of their ability to stick to vaginal mucosa. These films could potentially find applications in vaginal drug delivery

APPLICATION OF A PRELIMINARY (PRE-TRIAL) CRIMINAL PROCEEDINGS MODELING METHOD

Purpose: The article conducts the study application of a preliminary (pre-trial) criminal proceedings modeling method. Methodology: We have shown the important role of blended learning in the maintenance and development of the subject-subject model of interaction between students and teachers. The implementation of subject-subject interaction was considered on the example of the discipline "General and professional pedagogy", the electronic course of which is presented on the Moodle platform. Result: In our opinion, the main problem lies in the fact that the investigator constantly has to deal with various kinds of situations that need to be properly perceived, professionally analyzed, and, as quickly as possible, create a complete picture of what happened, however, it is not always possible. For this purpose, the subject of the investigation should use the entire arsenal of available methods, means, and methods that would allow knowing the event that occurred. Applications: This research can be used for universities, teachers, and students. Novelty/Originality: In this research, the model of application of a preliminary (pre-trial) criminal proceedings modeling method is presented in a comprehensive and complete manner

STUDENT VIEWS ON DOWNSHIFTER LIFESTYLE IN URBAN ENVIRONMENTS

Purpose of the study: The relevance of the article is due to the rethinking of employment by students and the emergence of new forms of income, due to the emergence of Internet resources.  Today, more and more people are revising their work schedules, switching to freelancing or so-called free employment, reducing working hours. In this regard, this article is aimed at studying students' ideas about the lifestyle of downshifters in an urban environment. Methodology: As a research methodology, a qualitative approach was applied using ethnographic strategies to dive into the world of everyday practices of informants and better understand how their daily lives are structured, which is especially important when studying ideas about lifestyle. A detailed description of the ideas about individual everyday practices allows us to identify the type in a social phenomenon. Method of information gathering - in-depth interview, which allows determining the main motives and beliefs of informants. Results: The article revealed that in the view of the majority of students, downshifters are satisfied with their lifestyle; travel a lot; have a low civil position, mainly carry out their household activities in solitude and are not married. It is shown that work for downshifters, in the view of students, should be enjoyable, and if this is not possible for any reason, it is fair for them to do work that does not lead to emotional and physical exhaustion. In the students' views, five groups of downshifters were identified: those who left well paid but stressful work; having the ability to work remotely; devoting more time to personal development; peaked careers and decided to change the profile of activity; transformed their hobby into a profession. Applications of this study: The data obtained in the work can be used in the field of labor and employment of young people, social psychology, the psychology of education, age psychology, sociology, as well as for further theoretical development of this issue. Novelty/Originality of this study: Because the phenomenon of downshifting is not sufficiently studied, and the concept has no clear definition, many people in the society can call themselves downshifters who are not really downshifters indeed, and Vice versa, many people do not realize themselves downshifters, being downshifters in fact. This seems to be a certain problem for studying this social group

Synthesis and Evaluation of a Conjugate Vaccine Composed of Staphylococcus aureus Poly-N-Acetyl-Glucosamine and Clumping Factor A

The increasing frequency, severity and antimicrobial resistance of Staphylococcus aureus infections has made the development of immunotherapies against this pathogen more urgent than ever. Previous immunization attempts using monovalent antigens resulted in at best partial levels of protection against S. aureus infection. We therefore reasoned that synthesizing a bivalent conjugate vaccine composed of two widely expressed antigens of S. aureus would result in additive/synergetic activities by antibodies to each vaccine component and/or in increased strain coverage. For this we used reductive amination, to covalently link the S. aureus antigens clumping factor A (ClfA) and deacetylated poly-N-β-(1–6)-acetyl-glucosamine (dPNAG). Mice immunized with 1, 5 or 10 µg of the dPNAG-ClfA conjugate responded in a dose-dependent manner with IgG to dPNAG and ClfA, whereas mice immunized with a mixture of ClfA and dPNAG developed significantly lower antibody titers to ClfA and no antibodies to PNAG. The dPNAG-ClfA vaccine was also highly immunogenic in rabbits, rhesus monkeys and a goat. Moreover, affinity-purified, antibodies to ClfA from dPNAG-ClfA immune serum blocked the binding of three S. aureus strains to immobilized fibrinogen. In an opsonophagocytic assay (OPKA) goat antibodies to dPNAG-ClfA vaccine, in the presence of complement and polymorphonuclear cells, killed S. aureus Newman and, to a lower extent, S. aureus Newman ΔclfA. A PNAG-negative isogenic mutant was not killed. Moreover, PNAG antigen fully inhibited the killing of S. aureus Newman by antisera to dPNAG-ClfA vaccine. Finally, mice passively vaccinated with goat antisera to dPNAG-ClfA or dPNAG-diphtheria toxoid conjugate had comparable levels of reductions of bacteria in the blood 2 h after infection with three different S. aureus strains as compared to mice given normal goat serum. In conclusion, ClfA is an immunogenic carrier protein that elicited anti-adhesive antibodies that fail to augment the OPK and protective activities of antibodies to the PNAG cell surface polysaccharide

Computed tomography depiction of normal inguinal lymph nodes in children

Background: The aim of the study was to establish computed tomography (CT) characteristics, distribution and provide normative data about size of normal inguinal lymph nodes in a paediatric population. Materials and methods: Four hundred eighty-one otherwise healthy children (147 girls, mean age: 8.87, range 0–17 years) underwent pelvic CT in the setting of high-energy trauma were included in the study. Both axial and coronal 1.25-mm reconstructions were evaluated for the presence, location (deep or superficial), number, presence of fat attenuation, and shape of the lymph nodes, short-axis diameter of the biggest lymph node for each of right and left inguinal regions. Results: A total of 7556 lymph nodes were detected in 481 subjects (the mean count of superficial and deep inguinal lymph nodes was 13.35 [range 6–23] and 2.36 [range 0–7] per subject, respectively): 15% (1135/7556) deep located, 85% (6421/7556) superficially located, 86.6% (6547/7556) with fat attenuation, 99.2% (7496/7556) oval in shape, 0.8% (60/7556) spherical. The short-axis diameter of the lymph nodes increased with age. Pearson’s correlation coefficient for superficial and deep lymph nodes in boys and girls, respectively: 0.538 (p < 0.001), 0.504 (p < 0.001), 0.452 (p < 0.001) and 0.268 (p < 0.001). The mean maximum short-axis diameters in different age groups and gender varied between 6.33 ± 0.85 mm and 8.68 ± 1.33 mm for superficial, 3.62 ± 1.16 mm and 5.83 ± 1.05 mm for deep inguinal lymph nodes. Conclusions: Inguinal lymph nodes were multiple, commonly contained fat, and were oval in shape. The data determined about inguinal lymph node size in different paediatric age groups may be applicable as normative data in daily clinical CT evaluation practice

Potential Synergy Activity of the Novel Ceragenin, CSA-13, against Carbapenem-Resistant Acinetobacter baumannii Strains Isolated from Bacteremia Patients

Carbapenem-resistant Acinetobacter baumannii is an important cause of nosocomial infections, particularly in patients in the intensive care units. As chronic infections are difficult to treat, attempts have been made to discover new antimicrobials. Ceragenins, designed to mimic the activities of antimicrobial peptides, are a new class of antimicrobial agents. In this study, the in vitro activities of CSA-13 either alone or in combination with colistin (sulphate), tobramycin, and ciprofloxacin were investigated using 60 carbapenem-resistant A. baumannii strains isolated from bacteremia patients blood specimens. MICs and MBCs were determined by microbroth dilution technique. Combinations were assessed by using checkerboard technique. The MIC 50 values (mg/L) of CSA-13, colistin, tobramycin, and ciprofloxacin were 2, 1, 1.25, and 80, respectively. The MIC 90 (mg/L) of CSA-13 and colistin were 8 and 4. The MBCs were equal to or twice greater than those of the MICs. Synergistic interactions were mostly seen with CSA-13-colistin (55%), whereas the least synergistic interactions were observed in the CSA-13-tobramycin (35%) combination. No antagonism was observed. CSA-13 appears to be a good candidate for further investigations in the treatment of A. baumannii infections. However, future studies should be performed to correlate the safety, efficacy, and pharmacokinetic parameters of this molecule

Quality and Safety Aspects of Infant Nutrition

Quality and safety aspects of infant nutrition are of key importance for child health, but oftentimes they do not get much attention by health care professionals whose interest tends to focus on functional benefits of early nutrition. Unbalanced diets and harmful food components induce particularly high risks for untoward effects in infants because of their rapid growth, high nutrient needs, and their typical dependence on only one or few foods during the first months of life. The concepts, standards and practices that relate to infant food quality and safety were discussed at a scientific workshop organized by the Child Health Foundation and the Early Nutrition Academy jointly with the European Society for Paediatric Gastroenterology, Hepatology and Nutrition, and a summary is provided here. The participants reviewed past and current issues on quality and safety, the role of different stakeholders, and recommendations to avert future issues. It was concluded that a high level of quality and safety is currently achieved, but this is no reason for complacency. The food industry carries the primary responsibility for the safety and suitability of their products, including the quality of composition, raw materials and production processes. Introduction of new or modified products should be preceded by a thorough science based review of suitability and safety by an independent authority. Food safety events should be managed on an international basis. Global collaboration of food producers, food-safety authorities, paediatricians and scientists is needed to efficiently exchange information and to best protect public health. Copyright (C) 2012 S. Karger AG, Base