English-learning infants’ perception of word stress patterns

Adult speakers of different free stress languages (e.g., English, Spanish) differ both in their sensitivity to lexical stress and in their processing of suprasegmental and vowel quality cues to stress. In a head-turn preference experiment with a familiarization phase, both 8-month-old and 12-month-old English-learning infants discriminated between initial stress and final stress among lists of Spanish-spoken disyllabic nonwords that were segmentally varied (e.g. [ˈnila, ˈtuli] vs [luˈta, puˈki]). This is evidence that English-learning infants are sensitive to lexical stress patterns, instantiated primarily by suprasegmental cues, during the second half of the first year of life

Appearance of the Single Gyroid Network Phase in Nuclear Pasta Matter

Nuclear matter under the conditions of a supernova explosion unfolds into a rich variety of spatially structured phases, called nuclear pasta. We investigate the role of periodic network-like structures with negatively curved interfaces in nuclear pasta structures, by static and dynamic Hartree-Fock simulations in periodic lattices. As the most prominent result, we identify for the first time the {\it single gyroid} network structure of cubic chiral $I4_123$ symmetry, a well known configuration in nanostructured soft-matter systems, both as a dynamical state and as a cooled static solution. Single gyroid structures form spontaneously in the course of the dynamical simulations. Most of them are isomeric states. The very small energy differences to the ground state indicate its relevance for structures in nuclear pasta.Comment: 7 pages, 4 figure

Identification of Exosite-Targeting Inhibitors of Anthrax Lethal Factor by High-Throughput Screening

SummaryProtease inhibitor discovery has focused almost exclusively on compounds that bind to the active site. Inhibitors targeting protease exosites, regions outside of the active site that influence catalysis, offer potential advantages of increased specificity but are difficult to systematically discover. Here, we describe an assay suitable for detecting exosite-targeting inhibitors of the metalloproteinase anthrax lethal factor (LF) based on cleavage of a full-length mitogen-activated protein kinase kinase (MKK) substrate. We used this assay to screen a small-molecule library and then subjected hits to a secondary screen to exclude compounds that efficiently blocked cleavage of a peptide substrate. We identified a compound that preferentially inhibited cleavage of MKKs compared with peptide substrates and could suppress LF-induced macrophage cytolysis. This approach should be generally applicable to the discovery of exosite-targeting inhibitors of many additional proteases

The Economics of Residential Solar and Battery Storage: Analyzing the Impact of the Joint IOU Proposal for Net Metering 3.0 in California

The California Public Utilities Commission (CPUC) is currently deciding on the structure of the next net metering program, which will determine how customers who install solar panels (and battery storage) under this new program will be compensated for excess energy that they export to the grid, and the additional fees that these solar customers will have to pay. The major investor-owned utility (IOU) companies in the state and some legislators have argued that the current net metering programs are far too generous to the customers and that they create an inequity by favoring the wealthy and causing a cost shift to the poorer non-solar customers. The IOUs have jointly proposed a set of regulations to the CPUC. In this paper, we examine the financial implications to residential customers who go solar under the new net metering program if the joint IOU proposal were to be adopted. We examine the case of a hypothetical southern California home that consumes the average amount of electricity (for that region) and estimate its electricity bills for various load profiles, assuming no solar or battery storage, with solar alone, and with solar and battery storage. For the two latter scenarios, we determine the ideal system configuration that will maximize the customer’s financial returns. In all cases, we determine that the joint IOU proposal for net metering will make residential solar panel and battery storage installations financially unattractive even in the best-case scenarios. In short, if the CPUC adopts the joint IOU proposal then residential solar installations in the state would likely come to an abrupt stop. We also analyze the economics of going off-grid (where a customer completely cuts himself off from the electrical grid) and find that it does not make sense for customers to go off-grid without being willing to cut consumption or make other compromises

On the effect of Ti on Oxidation Behaviour of a Polycrystalline Nickel-based Superalloy

Titanium is commonly added to nickel superalloys but has a well-documented detrimental effect on oxidation resistance. The present work constitutes the first atomistic-scale quantitative measurements of grain boundary and bulk compositions in the oxide scale of a current generation polycrystalline nickel superalloy performed through atom probe tomography. Titanium was found to be particularly detrimental to oxide scale growth through grain boundary diffusion

Local Anisotropy of Fluids using Minkowski Tensors

Statistics of the free volume available to individual particles have previously been studied for simple and complex fluids, granular matter, amorphous solids, and structural glasses. Minkowski tensors provide a set of shape measures that are based on strong mathematical theorems and easily computed for polygonal and polyhedral bodies such as free volume cells (Voronoi cells). They characterize the local structure beyond the two-point correlation function and are suitable to define indices $0\leq \beta_\nu^{a,b}\leq 1$ of local anisotropy. Here, we analyze the statistics of Minkowski tensors for configurations of simple liquid models, including the ideal gas (Poisson point process), the hard disks and hard spheres ensemble, and the Lennard-Jones fluid. We show that Minkowski tensors provide a robust characterization of local anisotropy, which ranges from $\beta_\nu^{a,b}\approx 0.3$ for vapor phases to $\beta_\nu^{a,b}\to 1$ for ordered solids. We find that for fluids, local anisotropy decreases monotonously with increasing free volume and randomness of particle positions. Furthermore, the local anisotropy indices $\beta_\nu^{a,b}$ are sensitive to structural transitions in these simple fluids, as has been previously shown in granular systems for the transition from loose to jammed bead packs

Minkowski Tensors of Anisotropic Spatial Structure

This article describes the theoretical foundation of and explicit algorithms for a novel approach to morphology and anisotropy analysis of complex spatial structure using tensor-valued Minkowski functionals, the so-called Minkowski tensors. Minkowski tensors are generalisations of the well-known scalar Minkowski functionals and are explicitly sensitive to anisotropic aspects of morphology, relevant for example for elastic moduli or permeability of microstructured materials. Here we derive explicit linear-time algorithms to compute these tensorial measures for three-dimensional shapes. These apply to representations of any object that can be represented by a triangulation of its bounding surface; their application is illustrated for the polyhedral Voronoi cellular complexes of jammed sphere configurations, and for triangulations of a biopolymer fibre network obtained by confocal microscopy. The article further bridges the substantial notational and conceptual gap between the different but equivalent approaches to scalar or tensorial Minkowski functionals in mathematics and in physics, hence making the mathematical measure theoretic method more readily accessible for future application in the physical sciences

Structure-based development of specific inhibitors for individual cathepsins and their medical applications

Specific inhibitors for individual cathepsins have been developed based on their tertiary structures of X-ray crystallography. Cathepsin B-specific inhibitors, CA-074 and CA-030, and cathepsin L specific inhibitors, CLIK-148 and CLIK-195, were designed as the epoxysuccinate derivatives. Cathepsin S inhibitor, CLIK-060, and cathepsin K inhibitor, CLIK-166, were synthesized. These inhibitors can use in vitro and also in vivo, and show no toxicity for experimental animals by the amounts used as the cathepsin inhibitor

Growth rate of small-scale dynamo at low magnetic Prandtl numbers

In this study we discuss two key issues related to a small-scale dynamo instability at low magnetic Prandtl numbers and large magnetic Reynolds numbers, namely: (i) the scaling for the growth rate of small-scale dynamo instability in the vicinity of the dynamo threshold; (ii) the existence of the Golitsyn spectrum of magnetic fluctuations in small-scale dynamos. There are two different asymptotics for the small-scale dynamo growth rate: in the vicinity of the threshold of the excitation of the small-scale dynamo instability, $\lambda \propto \ln({\rm Rm}/ {\rm Rm}^{\rm cr})$, and when the magnetic Reynolds number is much larger than the threshold of the excitation of the small-scale dynamo instability, $\lambda \propto {\rm Rm}^{1/2}$, where ${\rm Rm}^{\rm cr}$ is the small-scale dynamo instability threshold in the magnetic Reynolds number ${\rm Rm}$. We demonstrated that the existence of the Golitsyn spectrum of magnetic fluctuations requires a finite correlation time of the random velocity field. On the other hand, the influence of the Golitsyn spectrum on the small-scale dynamo instability is minor. This is the reason why it is so difficult to observe this spectrum in direct numerical simulations for the small-scale dynamo with low magnetic Prandtl numbers.Comment: 14 pages, 1 figure, revised versio