Enhanced monitoring of the preterm infant during stabilization in the delivery room

Monitoring of preterm infants in the delivery room (DR) remains limited. Current guidelines suggest that pulse oximetry should be available for all preterm infant deliveries, and that if intubated a colorimetric carbon dioxide detector should provide verification of correct endotracheal tube placement. These two methods of assessment represent the extent of objective monitoring of the newborn commonly performed in the DR. Monitoring non-invasive ventilation effectiveness (either by capnography or respiratory function monitoring) and cerebral oxygenation (near-infrared spectroscopy) is becoming more common within research settings. In this article, we will review the different modalities available for cardiorespiratory and neuromonitoring in the DR and assess the current evidence base on their feasibility, strengths, and limitations during preterm stabilization

Response: Commentary: Enhanced monitoring of the preterm infant during stabilization in the delivery room

A commentary on: Enhanced Monitoring of the Preterm Infant during Stabilization in the Delivery Room by Hutchon DJ. Front Pediatr (2016) 4:64. doi: 10.3389/fped.2016.0006

Correlations, inhomogeneous screening, and suppression of spin-splitting in quantum wires at strong magnetic fields

A self-consistent treatment of exchange and correlation interactions in a quantum wire (QW) subject to a strong perpendicular magnetic field is presented using a modified local-density approximation (MLDA). The influence of many-body interactions on the spin-splitting between the two lowest Landau levels (LLs) is calculated within the screened Hartree-Fock approximation (SHFA), for filling factor \nu=1, and the strong spatial dependence of the screening properties of electrons is taken into account. In comparison with the Hartree-Fock result, the spatial behavior of the occupied LL in a QW is strongly modified when correlations are included. Correlations caused by screening at the edges strongly suppress the exchange splitting and smoothen the energy dispersion at the edges. The theory accounts well for the experimentally observed strong suppression of the spin-splitting pertinent to the \nu=1 quantum Hall effect (QHE) state as well as the destruction of this state in long, quasi-ballistic GaAlAs/GaAs QWs.Comment: Text 23 pages in Latex/Revtex/preprint format, 6 Postscript figures, submitted to Physical Review

Design and performance testing of quantitative real time PCR assays for influenza A and B viral load measurement

Background: The antiviral effect of anti-influenza drugs such as zanamivir may be demonstrated in patients as an increased rate of decline in viral load over a time course of treatment as compared with placebo. Historically this was measured using plaque assays, or Culture Enhanced Enzyme Linked Immunosorbent Assay (CE-ELISA). Objectives: to develop and characterise real time quantitative PCR (qPCR) assays to measure influenza A and B viral load in clinical samples, that offer improvements over existing methods, in particular virus infectivity assays. Study design: The dynamic range and robustness were established for the real time qPCR assays along with stability of the assay components. Cross validation of the real time PCR assays with CE-ELISA was performed by parallel testing of both serial dilutions of three different subtypes of cultured virus and a panel of influenza positive throat swab specimens. Results: the assays were specific for influenza A and B and the dynamic ranges were at least seven logs. The assay variability was within acceptable limits but increased towards the lower limit of quantification, which was 3.33 log10 viral cDNA copies/ml of virus transport medium (ten viral RNA copies/PCR). The components of the assay were robust enough to withstand extended storage and several freeze–thawcycles. For the real time PCR assays the limit of quantification was equivalent to the virus infectivity cut off, which equates to a 93-fold increase in sensitivity. Conclusion: Well characterised real time PCR assays offer significant improvements over the existing methods for measuring the viral load of strains of influenza A and B in clinical specimens

A New Class of Resonances at the Edge of the Two Dimensional Electron Gas

We measure the frequency dependent capacitance of a gate covering the edge and part of a two-dimensional electron gas in the quantum Hall regime. In applying a positive gate bias, we create a metallic puddle under the gate surrounded by an insulating region. Charging of the puddle occurs via electron tunneling from a metallic edge channel. Analysis of the data allows direct extraction of this tunneling conductance. Novel conductance resonances appear as a function of gate bias. Samples with gates ranging from 1-170~$\mu$m along the edge display strikingly similar resonance spectra. The data suggest the existence of unexpected structure, homogeneous over long length scales, at the sample edge.Comment: 13 pages (revtex) including 4 figure

A revised age, structural model and origin for the North Pennine Orefield in the Alston Block, northern England: intrusion (Whin Sill)-related base metal (Cu–Pb–Zn–F) mineralization

Mineralization and associated fluid migration events in the c. 1500 km2 North Pennine Orefield (NPO) are known to be associated with tectonic activity, but the age of these tectonic events and origins of the base metal sulfide mineralization remain unresolved. New fieldwork in the Alston Block shows that mineralization post-dates a weakly developed phase of north–south shortening consistent with far-field Variscan basin inversion during the late Carboniferous. New observations of field relationships, coupled with microstructural observations and stress inversion analyses, together with Re–Os sulfide geochronology show that the vein-hosted mineralization (apart from barium minerals) was synchronous with a phase of north–south extension and east–west shortening coeval with emplacement of the Whin Sill (c. 297–294 Ma). Thus the development of the NPO was related to an early Permian regional phase of transtensional deformation, mantle-sourced hydrothermal mineralization and magmatism in northern Britain. Previously proposed Mississippi Valley Type models, or alternatives relating mineralization to the influx of Mesozoic brines, can no longer be applied to the development of the NPO in the Alston Block. Our findings also mean that existing models for equivalent base metal sulfide fields worldwide (e.g. Zn–Pb districts of Silesia, Poland and Tennessee, USA) may need to be reassessed

Far-Infrared Excitations below the Kohn Mode: Internal Motion in a Quantum Dot

We have investigated the far-infrared response of quantum dots in modulation doped GaAs heterostructures. We observe novel modes at frequencies below the center-of-mass Kohn mode. Comparison with Hartree-RPA calculations show that these modes arise from the flattened potential in our field-effect confined quantum dots. They reflect pronounced relative motion of the charge density with respect to the center-of-mass.Comment: 8 pages, LaTeX with integrated 6 PostScript figure

Charge and current oscillations in Fractional quantum Hall systems with edges

Stationary solutions of the Chern-Simons effective field theory for the fractional quantum Hall systems with edges are presented for Hall bar, disk and annulus. In the infinitely long Hall bar geometry (non compact case), the charge density is shown to be monotonic inside the sample. In sharp contrast, spatial oscillatory modes of charge density are found for the two circular geometries, which indicate that in systems with compact geometry, charge and current exist also far from the edges.Comment: 16 pages, 6 figures Revte

Solution of the Schr\"odinger Equation for Quantum Dot Lattices with Coulomb Interaction between the Dots

The Schr\"odinger equation for quantum dot lattices with non-cubic, non-Bravais lattices built up from elliptical dots is investigated. The Coulomb interaction between the dots is considered in dipole approximation. Then only the center of mass (c.m.) coordinates of different dots couple with each other. This c.m. subsystem can be solved exactly and provides magneto- phonon like collective excitations. The inter-dot interaction is involved only through a single interaction parameter. The relative coordinates of individual dots form decoupled subsystems giving rise to intra-dot excitations. As an example, the latter are calculated exactly for two-electron dots. Emphasis is layed on qualitative effects like: i) Influence of the magnetic field on the lattice instability due to inter-dot interaction, ii) Closing of the gap between the lower and the upper c.m. mode at B=0 for elliptical dots due to dot interaction, and iii) Kinks in the single dot excitation energies (versus magnetic field) due to change of ground state angular momentum. It is shown that for obtaining striking qualitative effects one should go beyond simple cubic lattices with spherical dots. We also prove a more general version of the Kohn Theorem for quantum dot lattices. It is shown that for observing effects of electron- electron interaction between the dots in FIR spectra (breaking Kohn's Theorem) one has to consider dot lattices with at least two dot species with different confinement tensors.Comment: 11 figures included as ps-file

Effect of isospin dependent cross-section on fragment production in the collision of charge asymmetric nuclei

To understand the role of isospin effects on fragmentation due to the collisions of charge asymmetric nuclei, we have performed a complete systematical study using isospin dependent quantum molecular dynamics model. Here simulations have been carried out for $^{124}X_{n}+ ^{124}X_{n}$, where n varies from 47 to 59 and for $^{40}Y_{m}+ ^{40}Y_{m}$, where m varies from 14 to 23. Our study shows that isospin dependent cross-section shows its influence on fragmentation in the collision of neutron rich nuclei