Raman spectra and Magnetization of all-ferromagnetic superlattices grown on (110) oriented SrTiO3

Superlattices consist of two ferromagnets La0.7Sr0.3MnO3(LSMO)and SrRuO3(SRO) were grown in (110)-orientation on SrTiO3(STO) substrates. The x-ray diffraction and Raman spectra of these superlattices show the presence of in-plane compressive strain and orthorhombic structure of less than 4 u.c. thick LSMO spacer,respectively. Magnetic measurements reveal several features including reduced magnetization, enhanced coercivity, antiferromagnetic coupling, and switching from antiferromagnetic to ferromagnetic coupling with magnetic field orientations. These magnetic properties are explained by the observed orthorhombic structure of spacer LSMO in Raman scattering which occurs due to the modification in the stereochemistry of Mn at the interfaces of SRO and LSMO

Characterization Of Glipizide-Loaded Polymethacrylate Microspheres Prepared By An Emulsion Solvent Evaporation Method

Purpose: The purpose of the present investigation was to formulate and evaluate microencapsulated glipizide produced by the emulsion – solvent evaporation method, Method: Microspheres were prepared using polymethacrylate polymers (Eudragit® RS 100 and RL 100) by solvent evaporation method and characterized for their micromeritic properties and drug loading, as well as by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy. In vitro release studies were performed in phosphate buffer (pH 7.4). Result: The resulting microspheres obtained by solvent evaporation method were white and free flowing in nature. The mean particle size of microspheres ranged from 420 - 660 μm and the encapsulation efficiencies ranged from 40.27 - 86.67 %. The encapsulation efficiency was also found to be dependant on nature of polymer used in the formulation. The infrared spectra confirmed the stable character of glipizide in the drug-loaded microspheres. Scanning electron microscopy revealed that the microspheres were spherical in nature. From the in vitro drug dissolution studies it was found that the sustaining effect of microspheres depended on the polymer concentration, amount of dispersant used and the type of polymer used in the formulation. The mechanism of drug release from the microspheres was found to be non-Fickian type. Conclusion: Eudragit® microspheres containing glipizide could be prepared successfully by using an emulsion solvent evaporation technique using polymethacrylate polymers, which will not only sustain the release of drug but also manage the complicacy of the diabetes in a better manner. Keywords: glipizide, Eudragit®, microspheres, controlled release, polymethacrylate.Tropical Journal of Pharmaceutical Research Vol. 7 (1) 2008: pp. 879-88

Evolution of microstructure and optical properties of TiO2/Au nanocomposite

TiO2/Au nanocomposite has been synthesized by mixing Au with milled TiO2 nanopowder through wet chemical route. The effect of Au on the microstructural and optical properties of TiO2 nanopowder has been studied by XRD, FESEM, UV Visible, PL and FTIR techniques. Our study indicates that Au causes the decrease of crystallite size of TiO2 by accumulating on the circumference of these nanoparticles. TiO2/Au nanocomposite exhibits strong spectral response in the visible range due to the surface plasmon effect. Band gap of TiO2 nanopowder reduces from 3.4 eV to 3.1 eV while making composite with Au. The PL spectra showed that emission peak intensity of TiO2 nanopowder decreases in the presence of Au. The reductions in band gap and electron-hole recombination in TiO2/Au nanocomposite suggest that TiO2/Au could be a good candidate for photocatalysis

Ergonomics of Farm Women in Manual Paddy Threshing

Thin-layer drying experiments with Roselle (Hibiscus sabdariffa .L) were carried out in a constant temperature and humidity chamber. Four temperatures (35, 45, 55, and 65°C) and five relative humidities (30, 35, 40, 45, and 50%RH) were tested. Statistical analysis on twelve thinlayer drying model proved the superiority of two-term exponential model. The objectives of this work were to evaluate and validate the two-term exponential model; besides, examine the effects of the drying conditions on the drying rate and constant. Validation of the developed model was done using two criterions, plotting of the predicted against experimental moisture contents and the residual versus predicted moisture content. The average values of the drying constant (k) and coefficient (a) weA study was taken up to have a comparative study on the ergonomics of farm women in pedal threshing with single and double operators (N =15) and to suggest modifications for further reduction of human drudgery. The mean HR work was found to be 135.9 ± 1.3 and 121.2 ±1.0 beats/min respectively with single and double operators; a significant (P < 0.01) reduction of 10.82 %. The corresponding work pulse (Δ HR) was 65.7 ± 0.9 and 51.5 ± 1.6 beats/min. The Δ HR was more than the allowable limit of 40 beats/min. HR work steadied after 6 minutes of threshing and there was complete recovery of HR after 6 minutes with double operators and 8 minutes with single operator. The increase in HR/kg of grain threshed was found to be 146.4 ± 4.4 and 76.0 ± 4.1 in case of single and double operators respectively; a significant reduction of 48 %. The workload decreased by 13.5 % with double operators but was still higher than the allowable limit of 35 % of VO2 max. The energy expenditure rate (ERR) was 18.9 ± 0.4 kJ/min with single operator and reduced to 16.6 ± 0.3 kJ/min with double operators. The total cardiac cost of work (TCCW) and physiological cost of work (PCW) reduced by 19.84 and 20 % with double operators. No significant variation of blood lactate accumulation between single and double operators was observed. The pedal force required was 232.3 ± 7.0 N and 199.7 ± 5.8 N in case of single operator and double operators respectively but was higher than the mean leg strength of the women of the eastern region of India. Higher pedal force application with double operators increased the number strokes/min (96/min) leading to a 51.15 % increase in output capacity of the thresher per hour per person. An increase of length of the pedal by 2 cm was suggested to reduce the force requirement. The length of the threshing drum can be reduced from 60.5 cm to 40 cm to be used by single operator or it can be increased to 75 cm to comfortably accommodate two persons.e 0.009167 and 0.776132, respectively

Fragmentation of a Circular Disc by Impact on a Frictionless Plate

The break-up of a two-dimensional circular disc by normal and oblique impact on a hard frictionless plate is investigated by molecular dynamics simulations. The disc is composed of numerous unbreakable randomly shaped convex polygons connected together by simple elastic beams that break when bent or stretched beyond a certain limit. It is found that for both normal and oblique impacts the crack patterns are the same and depend solely on the normal component of the impact velocity. Analysing the pattern of breakage, amount of damage, fragment masses and velocities, we show the existence of a critical velocity which separates two regimes of the impact process: below the critical point only a damage cone is formed at the impact site (damage), cleaving of the particle occurs at the critical point, while above the critical velocity the disc breaks into several pieces (fragmentation). In the limit of very high impact velocities the disc suffers complete disintegration (shattering) into many small fragments. In agreement with experimental results, fragment masses are found to follow the Gates-Gaudin-Schuhmann distribution (power law) with an exponent independent of the velocity and angle of impact. The velocity distribution of fragments exhibit an interesting anomalous scaling behavior when changing the impact velocity and the size of the disc.Comment: submitted to J. Phys: Condensed Matter special issue on Granular Medi

Preliminary investigation of the antioxidant, anti-diabetic, and anti-inflammatory activity of Enteromorpha intestinalis extracts

Marine algae are a promising source of potent bioactive agents against oxidative stress, diabetes, and inflammation. However, the possible therapeutic effects of many algal metabolites have not been exploited yet. In this regard, we explored the therapeutic potential of Enteromorpha intestinalis extracts obtained from methanol, ethanol, and hexane, in contrasting oxidative stress. The total phenolic (TPC) and flavonoids (TFC) content were quantified in all extracts, with ethanol yielding the best values (about 60 and 625 mg of gallic acid and rutin equivalents per gram of extract, respectively). Their antioxidant potential was also assessed through DPPH•, hydroxyl radical, hydrogen peroxide, and superoxide anion scavenging assays, showing a concentration-dependent activity which was greater in the extracts from protic and more polar solvents. The α-amylase and α-glucosidase activities were estimated for checking the antidiabetic capacity, with IC50 values of about 3.8 μg/mL for the methanolic extract, almost as low as those obtained with acarbose (about 2.8 and 3.3 μg/mL, respectively). The same extract also showed remarkable anti-inflammatory effect, as determined by hemolysis, protein denaturation, proteinase and lipoxygenase activity assays, with respectable IC50 values (about 11, 4, 6, and 5 μg/mL, respectively), also in comparison to commercially used drugs, such as acetylsalicylic acid