Non-equilibrium mechanics and dynamics of motor activated gels

The mechanics of cells is strongly affected by molecular motors that generate forces in the cellular cytoskeleton. We develop a model for cytoskeletal networks driven out of equilibrium by molecular motors exerting transient contractile stresses. Using this model we show how motor activity can dramatically increase the network's bulk elastic moduli. We also show how motor binding kinetics naturally leads to enhanced low-frequency stress fluctuations that result in non-equilibrium diffusive motion within an elastic network, as seen in recent \emph{in vitro} and \emph{in vivo} experiments.Comment: 21 pages, 8 figure

Nematic and Polar order in Active Filament Solutions

Using a microscopic model of interacting polar biofilaments and motor proteins, we characterize the phase diagram of both homogeneous and inhomogeneous states in terms of experimental parameters. The polarity of motor clusters is key in determining the organization of the filaments in homogeneous isotropic, polarized and nematic states, while motor-induced bundling yields spatially inhomogeneous structures.Comment: 4 pages. 3 figure

Direct Current Electrical Stimulation Increases the Fusion Rate of Spinal Fusion Cages

Study Design. A randomized experimental evaluation of direct current stimulation in a validated animal model with an experimental control group, using blinded radiographic, biomechanical, histologic, and statistical measures. Objectives. To evaluate the efficacy of the adjunctive use of direct current stimulation on the fusion rate and speed of healing of titanium interbody fusion cages packed with autograft in a sheep lumbar interbody fusion model. Summary of Background Data. Titanium lumbar interbody spinal fusion cages have been reported to be 90% effective for single-level lumbar interbody fusion. However, fusion rates are reported to be between 70% and 80% in patients with multilevel fusions or with risk factors such as obesity, tobacco use, or metabolic disorders. The authors hypothesized that direct current stimulation would increase the fusion rate of titanium interbody fusion cages packed with autograft in a sheep lumbar interbody fusion model. Methods. Twenty-two sheep underwent lumbar discectomy and fusion at L4–L5 with an 11- × 20-mm Bagby and Kuslich (BAK) cage packed with autograft. Seven sheep received a BAK cage and no current. Seven sheep had a cage and a 40-μA current applied with a direct current stimulator. Eight sheep had a BAK cage and a 100-μA current applied. All sheep were killed 4 months after surgery. The efficacy of electrical stimulation in promoting interbody fusion was assessed by performing radiographic, biomechanical, and histologic analyses in a blinded fashion. Results. The histologic fusion rate increased as the direct current dose increased from 0 μA to 40 μA to 100 μA (P \u3c 0.009). Histologically, all animals in the 100-μA group had fusions in both the right and left sides of the cage. Direct current stimulation had a significant effect on increasing the stiffness of the treated motion segment in right lateral bending (P \u3c 0.120), left lateral bending (P \u3c 0.017), right axial rotation (P \u3c 0.004), left axial rotation (P \u3c 0.073), extension (P \u3c 0.078), and flexion (P \u3c 0.029) over nonstimulated levels. Conclusion. Direct current stimulation increased the histologic and biomechanical fusion rate and the speed of healing of lumbar interbody spinal fusion cages in an ovine model at 4 months

A Chandra View of the Normal SO Galaxy NGC 1332: II: Solar Abundances in the Hot Gas and Implications for SN Enrichment

We present spectral analysis of the diffuse emission in the normal, isolated, moderate-Lx S0 NGC 1332, constraining both the temperature profile and the metal abundances in the ISM. The characteristics of the point source population and the gravitating matter are discussed in two companion papers. The diffuse emission comprises hot gas, with an ~isothermal temperature profile (~0.5 keV), and emission from unresolved point-sources. In contrast with the cool cores of many groups and clusters, we find a small central temperature peak. We obtain emission-weighted abundance contraints within 20 kpc for several key elements: Fe, O, Ne, Mg and Si. The measured iron abundance (Z_Fe=1.1 in solar units; >0.53 at 99% confidence) strongly excludes the very sub-solar values often historically reported for early-type galaxies but agrees with recent observations of brighter galaxies and groups. The abundance ratios, with respect to Fe, of the other elements were also found to be ~solar, although Z_o/Z_Fe was significantly lower (<0.4). Such a low O abundance is not predicted by simple models of ISM enrichment by Type Ia and Type II supernovae, and may indicate a significant contribution from primordial hypernovae. Revisiting Chandra observations of the moderate-Lx, isolated elliptical NGC 720, we obtain similar abundance constraints. Adopting standard SNIa and SNII metal yields, our abundance ratio constraints imply 73+/-5% and 85+/-6% of the Fe enrichment in NGC 1332 and NGC 720, respectively, arises from SNIa. Although these results are sensitive to the considerable systematic uncertainty in the SNe yields, they are in good agreement with observations of more massive systems. These two moderate-Lx early-type galaxies reveal a consistent pattern of metal enrichment from cluster scales to moderate Lx/Lb galaxies. (abridged)Comment: 12 pages, 4 figures, accepted for publication in ApJ. Minor changes to match published versio

Permeation of CO2 and N2 through glassy poly(dimethyl phenylene) oxide under steady- and presteady-state conditions

Glassy polymers are often used for gas separations because of their high selectivity. Although the dual-mode permeation model correctly fits their sorption and permeation isotherms, its physical interpretation is disputed, and it does not describe permeation far from steady state, a condition expected when separations involve intermittent renewable energy sources. To develop a more comprehensive permeation model, we combine experiment, molecular dynamics, and multiscale reaction–diffusion modeling to characterize the time-dependent permeation of N2 and CO2 through a glassy poly(dimethyl phenylene oxide) membrane, a model system. Simulations of experimental time-dependent permeation data for both gases in the presteady-state and steady-state regimes show that both single- and dual-mode reaction–diffusion models reproduce the experimental observations, and that sorbed gas concentrations lag the external pressure rise. The results point to environment-sensitive diffusion coefficients as a vital characteristic of transport in glassy polymers

Extremely Metal-Poor Galaxies: The HI Content

Extremely metal-poor (XMP) galaxies are chemically, and possibly dynamically, primordial objects in the local Universe. Our objective is to characterize the HI content of the XMP galaxies as a class, using as a reference the list of 140 known local XMPs compiled by Morales-Luis et al. (2011). We have observed 29 XMPs, which had not been observed before at 21 cm, using the Effelsberg radio telescope. This information was complemented with HI data published in literature for a further 53 XMPs. In addition, optical data from the literature provided morphologies, stellar masses, star-formation rates and metallicities. Effelsberg HI integrated flux densities are between 1 and 15 Jy km/s, while line widths are between 20 and 120 km/s. HI integrated flux densities and line widths from literature are in the range 0.1 - 200 Jy km/s and 15 - 150 km/s, respectively. Of the 10 new Effelsberg detections, two sources show an asymmetric double-horn profile, while the remaining sources show either asymmetric (7 sources) or symmetric (1 source) single-peak 21 cm line profiles. An asymmetry in the HI line profile is systematically accompanied by an asymmetry in the optical morphology. Typically, the g-band stellar mass-to-light ratios are ~0.1, whereas the HI gas mass-to-light ratios may be up to 2 orders of magnitude larger. Moreover, HI gas-to-stellar mass ratios fall typically between 10 and 20, denoting that XMPs are extremely gas-rich. We find an anti-correlation between the HI gas mass-to-light ratio and the luminosity, whereby fainter XMPs are more gas-rich than brighter XMPs, suggesting that brighter sources have converted a larger fraction of their HI gas into stars. The dynamical masses inferred from the HI line widths imply that the stellar mass does not exceed 5% of the dynamical mass, while the \ion{H}{i} mass constitutes between 20 and 60% of the dynamical mass. (abridged)Comment: 30 pages, accepted for A&

A predictive phenomenological tool at small Bjorken-x

We present the results from global fits of inclusive DIS experimental data using the Balitsky-Kovchegov equation with running coupling.Comment: 5 pages, 2 figures, prepared for the Proceedings of 'Hot Quarks 2010

Shear flow induced isotropic to nematic transition in a suspension of active filaments

We study the effects of externally applied shear flow on a model of suspensions of motors and filaments, via the equations of active hydrodynamics [PRL {\bf 89} (2002) 058101; {\bf 92} (2004) 118101]. In the absence of shear, the orientationally ordered phase of {\it both} polar and apolar active particles is always unstable at zero-wavenumber. An imposed steady shear large enough to overcome the active stresses stabilises both apolar and moving polar phases. Our work is relevant to {\it in vitro} studies of active filaments, the reorientation of endothelial cells subject to shear flow and shear-induced motility of attached cells.Comment: 8 pages, 4 figures submitted to Europhysics Letter

Cumulative Risk Effects in the Bullying of Children and Young People with Autism Spectrum Conditions

Students with autism are more likely to be bullied than their typically developing peers. However, several studies have shown that their likelihood of being bullied increases in the context of exposure to certain risk factors (e.g. behaviour difficulties, poor peer relationships). This study explores vulnerability to bullying from a cumulative risk perspective, where the number of risks rather than their nature is considered. 722 teachers and 119 parents of young people with ASC participated in the study. Established risk factors were summed to form a cumulative risk score in teacher and parent models. There was evidence of a cumulative risk effect in both models, suggesting that as the number of risks increased, so did exposure to bullying. A quadratic effect was found in the teacher model, indicating that there was a disproportionate increase in the likelihood of being bullied in relation to the number of risk factors to which a young person was exposed. In light of these findings, it is proposed that more attention needs to be given to the number of risks to which children and young people with ASC are exposed when planning interventions and providing a suitable educational environment