Nonautonomous Hamiltonian Systems and Morales-Ramis Theory I. The Case x¨=f(x,t)\ddot{x}=f(x,t)

In this paper we present an approach towards the comprehensive analysis of the non-integrability of differential equations in the form $\ddot x=f(x,t)$ which is analogous to Hamiltonian systems with 1+1/2 degree of freedom. In particular, we analyze the non-integrability of some important families of differential equations such as Painlev\'e II, Sitnikov and Hill-Schr\"odinger equation. We emphasize in Painlev\'e II, showing its non-integrability through three different Hamiltonian systems, and also in Sitnikov in which two different version including numerical results are shown. The main tool to study the non-integrability of these kind of Hamiltonian systems is Morales-Ramis theory. This paper is a very slight improvement of the talk with the almost-same title delivered by the author in SIAM Conference on Applications of Dynamical Systems 2007.Comment: 15 pages without figures (19 pages and 6 figures in the published version

Two-dimensional approach to relativistic positioning systems

A relativistic positioning system is a physical realization of a coordinate system consisting in four clocks in arbitrary motion broadcasting their proper times. The basic elements of the relativistic positioning systems are presented in the two-dimensional case. This simplified approach allows to explain and to analyze the properties and interest of these new systems. The positioning system defined by geodesic emitters in flat metric is developed in detail. The information that the data generated by a relativistic positioning system give on the space-time metric interval is analyzed, and the interest of these results in gravimetry is pointed out.Comment: 11 pages, 5 figures. v2: a brief description of the principal bibliography has been adde

The Agents-are-Substitutes Property in Continuous Generalized Assignment Problems

The VCG mechanism has some nice properties if the agents-are-substitutes property holds.For example, for combinatorial auctions the property assures that the VCG mechanism is supported by a pricing equilibrium. The existence of such a pricing equilibrium is a necessary condition for the existence of ascending auctions that are equivalent to the VCG mechanism.Although it is known that the agents-are-substitutes property is important in several settings few problems or subclasses of problems are proven to have the property.In this paper we show for a class of problems that the agents-are-substitutes property holds. Moreover we give two rather natural and small extensions that do not have this property in general.Furthermore we show that in our simple problem class we need the possibility of price discrimination.operations research and management science;

AdS/CFT correspondence and D1/D5 systems in theories with 16 supercharges

We discuss spectra of $AdS_3$ supergravities, arising in the near horizon geometry of D1/D5 systems in orbifolds/orientifolds of type IIB theory with 16 supercharges. These include models studied in a recent paper (hep-th/0012118), where the group action involves also a shift along a transversal circle, as well as IIB/$\Omega I_4$, which is dual to IIB on $K3$. After appropriate assignements of the orbifold group eigenvalues and degrees to the supergravity single particle spectrum, we compute the supergravity elliptic genus and find agreement, in the expected regime of validity, with the elliptic genus obtained using U-duality map from (4,4) CFTs of U-dual backgrounds. Since this U-duality involves the exchange of KK momentum $P$ and D1 charge $N$, it allows us to test the (4,4) CFTs in the $P < N/4$ and $N < P/4$ regimes by two different supergravity duals.Comment: 28 pages, no figure

Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1

In a screen designed to discover suppressors of mitotic catastrophe, we identified the Xenopus ortholog of 53BP1 (X53BP1), a BRCT protein previously identified in humans through its ability to bind the p53 tumor suppressor. X53BP1 transcripts are highly expressed in ovaries, and the protein interacts with Xp53 throughout the cell cycle in embryonic extracts. However, no interaction between X53BP1 and Xp53 can be detected in somatic cells, suggesting that the association between the two proteins may be developmentally regulated. X53BP1 is modified via phosphorylation in a DNA damage-dependent manner that correlates with the dispersal of X53BP1 into multiple foci throughout the nucleus in somatic cells. Thus, X53BP1 can be classified as a novel participant in the DNA damage response pathway. We demonstrate that X53BP1 and its human ortholog can serve as good substrates in vitro as well as in vivo for the ATM kinase. Collectively, our results reveal that 53BP1 plays an important role in the checkpoint response to DNA damage, possibly in collaboration with ATM

Integrability of Stochastic Birth-Death processes via Differential Galois Theory

Stochastic birth-death processes are described as continuous-time Markov processes in models of population dynamics. A system of infinite, coupled ordinary differential equations (the so-called master equation) describes the time-dependence of the probability of each system state. Using a generating function, the master equation can be transformed into a partial differential equation. In this contribution we analyze the integrability of two types of stochastic birth-death processes (with polynomial birth and death rates) using standard differential Galois theory. We discuss the integrability of the PDE via a Laplace transform acting over the temporal variable. We show that the PDE is not integrable except for the (trivial) case in which rates are linear functions of the number of individuals