Merging several separate data acquisition systems at GANIL

International audienceThe Grand Accélérateur National d'Ions (GANIL) as a National User's facility must answer to the problems of synchronization for the coupling of resident and external acquisition systems. For this a solution made up of a C-size VXI electronics called CENTRUM and a software named MERGER was adopted. The technique used for synchronization is based on the distribution of a 32-bit event number or a 48-bit timestamp. The tagged events sent by the various acquisition systems on the network are assembled by MERGER in a single event and sent for the analysis and storag

Influence of Nitrogen Fertilization on the Quality and Quantity of Streamflow from a Forested Watershed

This project was designed to determine the effects of nitrogen fertilization on the quality and quantity of streamflow eminating from an eastern hardwood forest watershed. A 40.67 ha watershed, located in mountainous eastern Kentucky, was aerially fertilized in late April 1975. The forest stand was principally oak, hickory, and yellow poplar, 50 - 55 years of age and in a relatively undisturbed condition. A helicopter applied anunonium nitrate at a rate of 504 kg/ha. Because a large part of applied nitrogen fertilizer ends up in the highly mobile nitrate nitrogen.form, this is the principal ion monitored in this study. No effort was made to avoid live streams during application and, consequently, very high levels of nitrate nitrogen were detected (640 mg/1) in streamfiow within the watershed. Levels potentially toxic to humans and animals persisted in the streamflow for several days following application. Although elevated concentrations of nitrate nitrogen persisted in streamflow leaving the watershed over a two year period no algal blooms or excessive growth of aquatic plants were noted. Rather high concentrations of nitrate nitrogen were found in the soils of the watershed, with greatest concentrations in the surface layer (0 - 5 cm), intermediate amounts at 15 - 20 cm, and the lowest concentrations at the 41 - 46 cm depth. The effects of the fertilizer application on soils persisted less than one year in the 0 - 46 cm depth sampled. Analysis of streamf1ow records indicated a reduction in water yield the first and second growing seasons after treatment. Gross budgeting of nitrate nitrogen inputs vs. outputs suggests this anion accumulates on these relatively undisturbed watersheds at an annual rate of 3 to 5 kg/ha

Effect of substrate thermal resistance on space-domain microchannel

In recent years, Fluorescent Melting Curve Analysis (FMCA) has become an almost ubiquitous feature of commercial quantitative PCR (qPCR) thermal cyclers. Here a micro-fluidic device is presented capable of performing FMCA within a microchannel. The device consists of modular thermally conductive blocks which can sandwich a microfluidic substrate. Opposing ends of the blocks are held at differing temperatures and a linear thermal gradient is generated along the microfluidic channel. Fluorescent measurements taken from a sample as it passes along the micro-fluidic channel permits fluorescent melting curves to be generated. In this study we measure DNA melting temperature from two plasmid fragments. The effects of flow velocity and ramp-rate are investigated, and measured melting curves are compared to those acquired from a commercially available PCR thermocycler

Cross-site assessment of road design packages

This report develop a concept for evaluating alternative design solutions for urban streets: the Street Performance Assessment Scheme. It should be generally valid and applicable to any redesign task, to compare the performance of a road/street section: (1) with the goals formulated for each case study, (2) in situations before and after the implementation of a redesign solution, and (3) between different case studies in cross-site assessments. In this report, the Street Performance Assessment Scheme is applied to streets in five European cities. These streets have major movement and 'place' functions and have limited space availabilities, and are thus typical examples for the most challenging design tasks that urban street designers face

Built Environment Determinants of Pedestrian Activities and Their Consideration in Urban Street Design

Pedestrian facilities have been regarded in urban street design as “leftover spaces” for years, but, currently, there is a growing interest in walking and improving the quality of street environments. Designing pedestrian facilities presents the challenge of simultaneously accommodating (1) pedestrians who want to move safely and comfortably from point A to B (movement function); as well as (2) users who wish to rest, communicate, shop, eat, and enjoy life in a pleasant environment (place function). The aims of this study are to provide an overview of how the task of designing pedestrian facilities is addressed in international guidance material for urban street design, to compare this with scientific evidence on determinants of pedestrian activities, and to finally develop recommendations for advancing provisions for pedestrians. The results show that urban street design guidance is well advanced in measuring space requirements for known volumes of moving pedestrians, but less in planning pleasant street environments that encourage pedestrian movement and place activities. A stronger linkage to scientific evidence could improve guidance materials and better support urban street designers in their ambition to provide safe, comfortable and attractive street spaces that invite people to walk and to stay

Avaliação das Flutuações de Concentração em uma Pluma de Dispersão de Poluentes

Avaliação das flutuações de concentração em uma pluma dedispersão de poluente

Scaling of the Critical Function for the Standard Map: Some Numerical Results

The behavior of the critical function for the breakdown of the homotopically non-trivial invariant (KAM) curves for the standard map, as the rotation number tends to a rational number, is investigated using a version of Greene's residue criterion. The results are compared to the analogous ones for the radius of convergence of the Lindstedt series, in which case rigorous theorems have been proved. The conjectured interpolation of the critical function in terms of the Bryuno function is discussed.Comment: 26 pages, 3 figures, 13 table

Head-to-head comparison of two angiography-derived fractional flow reserve techniques in patients with high-risk acute coronary syndrome: A multicenter prospective study.

FFRangio and QFR are angiography-based technologies that have been validated in patients with stable coronary artery disease. No head-to-head comparison to invasive fractional flow reserve (FFR) has been reported to date in patients with acute coronary syndromes (ACS). This study is a subset of a larger prospective multicenter, single-arm study that involved patients diagnosed with high-risk ACS in whom 30-70% stenosis was evaluated by FFR. FFRangio and QFR - both calculated offline by 2 different and blinded operators - were calculated and compared to FFR. The two co-primary endpoints were the comparison of the Pearson correlation coefficient between FFRangio and QFR with FFR and the comparison of their inter-observer variability. Among 134 high-risk ACS screened patients, 59 patients with 84 vessels underwent FFR measurements and were included in this study. The mean FFR value was 0.82 ± 0.40 with 32 (38%) being ≤0.80. The mean FFRangio was 0.82 ± 0.20 and the mean QFR was 0.82 ± 0.30, with 27 (32%) and 25 (29%) being ≤0.80, respectively. The Pearson correlation coefficient was significantly better for FFRangio compared to QFR, with R values of 0.76 and 0.61, respectively (p = 0.01). The inter-observer agreement was also significantly better for FFRangio compared to QFR (0.86 vs 0.79, p < 0.05). FFRangio had 91% sensitivity, 100% specificity, and 96.8% accuracy, while QFR exhibited 86.4% sensitivity, 98.4% specificity, and 93.7% accuracy. In patients with high-risk ACS, FFRangio and QFR demonstrated excellent diagnostic performance. FFRangio seems to have better correlation to invasive FFR compared to QFR but further larger validation studies are required

Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry

The analysis of myo-inositol phosphates (InsPs) and myo-inositol pyrophosphates (PP-InsPs) is a daunting challenge due to the large number of possible isomers, the absence of a chromophore, the high charge density, the low abundance, and the instability of the esters and anhydrides. Given their importance in biology, an analytical approach to follow and understand this complex signaling hub is desirable. Here, capillary electrophoresis (CE) coupled to electrospray ionization mass spectrometry (ESI-MS) is implemented to analyze complex mixtures of InsPs and PP-InsPs with high sensitivity. Stable isotope labeled (SIL) internal standards allow for matrix-independent quantitative assignment. The method is validated in wild-type and knockout mammalian cell lines and in model organisms. SIL-CE-ESI-MS enables the accurate monitoring of InsPs and PP-InsPs arising from compartmentalized cellular synthesis pathways, by feeding cells with either [13C6]-myo-inositol or [13C6]-D-glucose. In doing so, we provide evidence for the existence of unknown inositol synthesis pathways in mammals, highlighting the potential of this method to dissect inositol phosphate metabolism and signalling