Drug utilization study of anti-hypertensive drugs in a tertiary care hospital

Background: Hypertension is a major non-communicable disease and a risk factor for cardiovascular diseases. The antihypertensive drugs used for its management constitute a significant portion of the medicines prescribed in a health care centre. The aim of our study was to analyse the utilization pattern of anti-hypertensive drugs at a tertiary care hospital in accordance with the WHO prescription indicators.Methods: A prospective cross sectional observational study was carried out in the outpatient of general medicine department of Osmania General Hospital. The prescriptions of the hypertensive patients visiting the outpatient were monitored. From the data collected, the prescription pattern of antihypertensive drugs, and WHO prescription indicators, were analysed.Results: Out of the 301study subjects, 134 (44.51%) were males and 167 (55.48%) were females, with the maximum number of patients (197) falling in the age group 51-70 years. Among the antihypertensive drugs prescribed, Amlodipine was most frequently prescribed (53.15%). The frequently used drugs for monotherapy - amlodipine (26.91%) and for two drug therapy - amlodipine+enalapril (17.27%), and for three drug therapy - atenolol+enalapril+nifedipine (2.32%). The WHO prescribing indicators as analyzed from the data collected are; Average number of drugs prescribed per encounter - 5.64/prescription, Percentage of medicines prescribed by generic name - 89.22%, Percentage of medicines prescribed from essential drug list -90.17% .Conclusions: The study provides an insight into antihypertensive drug usage pattern in tertiary care hospital and their rational use. The study emphasizes the need for preventive measures and effective educative measures in the population about hypertension

Light Curves of Rapidly Rotating Neutron Stars

We consider the effect of rapid rotation on the light curves of neutron stars with hot polar caps. For $P \approx 3$ms spin periods, the pulse fractions can be as much as an order of magnitude larger than with simple slowly-rotating (Schwarzschild) estimates. Doppler boosting, in particular, leads to characteristic distortion and ``soft lags'' in the pulse profiles, which are easily measurable in light curves with moderate energy resolution. With $\sim 10^5$ photons it should also be possible to isolate the more subtle distortions of light travel time variations and frame dragging. Detailed analysis of high quality millisecond pulsar data from upcoming X-ray missions must include these effects

Concept of Grip Assistive Braking on Four Wheelers

Braking systems in all the segments of vehicles seems to be one of the most crucial developing systems. Many research and developments are carried out in terms of braking of a vehicle in order to enhance the braking efficiency and reduction in stopping distance. This article depicts the concept of assistive braking on four wheelers where we elaborately describe the Braking distance, Thinking distance and Stopping distance after which our concept of braking is proposed with all the technical aspects along with the various components and its efficiency in our real time use. This research article mainly focuses on technical aspects that aim to reduce the reaction time and reflex actions of the driver which in turn is used as a factor to reduce the stopping distance of the vehicle. Various types of biological reactions by a human are observed and then a particular muscular reaction is chosen as a source of intimation for our braking system. When an object is spotted by the driver, the reflex action takes place via a receptor, sensory neurons, spinal cord and from where the muscular reaction takes place. A unique steering with an array of grip sensors is designed and incorporated also with various functions of the vehicle but for this instance, we mainly focus on braking assistance of the vehicle. Thus the unique steering wheel plays the role of connection between vehicle and the driver

'Cashew Apple' Juice Blend with Mango, Pineapple and Sapota for Improving Quality of RTS Beverages and Economic Feasibility Thereof

The present study on value-addition in cashew apple (Anacardium occidentale L.) juice by blending it with mango, pineapple and sapota juices for preparation of RTS beverage was conducted during the year 2012-2013 at Horticultural College and Research Institute, Dr. YSR Horticultural University, Andhra Pradesh, in Completely Randomized Design (CRD) with 3 replications and 10 treatments. In the present investigation, 'cashew apple' juice extracted from the fruit was blended with fruit juices of mango, pineapple and sapota in various proportions. RTS beverages prepared from different blends of cashew apple juice were evaluated for physico-chemical and organoleptic properties at 0, 30 and 60 days of storage, and significant differences were observed. RTS beverage prepared from a blend of 25% cashew apple juice + 75% mango juice (T3) recorded a gradual decrease in pH, titrable acidity and ascorbic acid content from 0 to 60 days after storage, whereas, density of the blended juice increased gradually at 0 to 30 days of storage; thereafter it decreased. Total soluble solids, reducing sugars and TSS/Acid ratio gradually increased from 0 to 60 days of storage, followed by 25% cashew apple juice + 75% pineapple juice (T6). Organoleptic score for RTS prepared from 25% cashew apple juice + 75% mango juice blend (T3), followed by 50% cashew apple juice + 50% mango juice blend (T2), 25% cashew apple juice + 75% pineapple juice blend (T6) and 50% cashew apple juice + 50% pineapple juice blend (T5), were found to be high on quality, viz., colour, taste and overall acceptability, up to 60 days of storage, and were economical for RTS preparation

Case report-baboon syndrome with paracetamol

Adverse drug reaction (ADR) is defined as “any response to drug which is noxious or unintended and occurs at a dose normally used in man for prophylaxis, diagnosis or treatment of diseases or for modification of physiological function”. Among the ADRs reported, cutaneous drug reactions are most common. Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), also known as baboon syndrome (BS), is included in the spectrum of systemically induced allergic contact dermatitis. Characteristics of SDRIFE include a sharply defined symmetric erythema in the gluteal area and in the flexural or intertriginous folds without any systemic symptoms or signs. We present a case of 30-year-old female with baboon syndrome after taking the combination of paracetamol and diclofenac. Awareness of SDRIFE (BS) as an unusual drug reaction is especially important since the connection between skin eruption and drug exposure may easily be overlooked or misdiagnosed

Role of neutron transfer in the reaction mechanism of 9^9Be+169^{169}Tm, 181^{181}Ta, 187^{187}Re and 197^{197}Au systems

The contribution of one neutron stripping cross section to the total reaction cross section has been studied for $^9$Be projectile incident on $^{169}$Tm, $^{181}$Ta, $^{187}$Re and $^{197}$Au targets around Coulomb barrier energy. The measured one neutron stripping cross sections for these systems have been compared with the coupled channel calculations. The recently developed global set of optical model potential parameters for $^9$Be projectile has been used in the present calculations. The cumulative of measured complete fusion (CF), incomplete fusion (ICF), one neutron stripping and calculated non-capture breakup (NCBU) cross sections is found to explain almost the reaction cross sections for all the targets. A very small contribution from target inelastic states and elastic breakup may contribute to the remaining part. The percentage fraction of cross section for CF, ICF, one neutron stripping, and NCBU over reaction cross section show the dominance of neutron transfer and NCBU at below barrier energies while CF and ICF processes have the major contribution at above barrier energies.Comment: 12 pages, 3 figure

Serum magnesium and its association with vascular calcification in chronic kidney disease patients on haemodialysis

Background: Cardiovascular disease is one of the leading causes of death in chronic kidney disease (CKD). It has been observed that haemodialysis patients have a high prevalence of cardiac risk factors with further risk due to abnormal mineral metabolism. A study has demonstrated that a higher serum magnesium significantly decreased the mortality risk in haemodialysis patients and lower serum Mg level has been found to be associated with increased mortality in them. The aim of the study was to characterize the relationship between Mg level and vascular calcification in CKD patients.Methods: It was a cross sectional study conducted in 100 CKD patients attending outpatient and inpatient ward of Tagore Medical College and Hospital, Chennai, Tamil Nadu, India. Serum magnesium levels will be measured using Xylidyl blue method. Carotid intimal medial thickness will be measured using Doppler.Results: In the study 10 patients did not show the sign of any calcification. Among the remaining 90 patients, 42 patients showed calcification and 48 patients showed stenosis. The statistical analysis showed a spearman correlation coefficient value of 0.201 thus showing only a weak association.Conclusion: The present study showed that only a weak relationship exists between the magnesium level and vascular calcification

Serum Magnesium and Its Association with Vascular Calcification in Chronic Kidney Disease Patients on Haemodialysis

Background: Cardiovascular disease is one of the leading causes of death in chronic kidney disease (CKD). It has been observed that haemodialysis patients have a high prevalence of cardiac risk factors with further risk due to abnormal mineral metabolism. A study has demonstrated that a higher serum magnesium significantly decreased the mortality risk in haemodialysis patients and lower serum Mg level has been found to be associated with increased mortality in them. The aim of the study was to characterize the relationship between Mg level and vascular calcification in CKD patients. Methods: It was a cross sectional study conducted in 100 CKD patients attending outpatient and inpatient ward of Tagore Medical College and Hospital, Chennai, Tamil Nadu, India. Serum magnesium levels will be measured using Xylidyl blue method. Carotid intimal medial thickness will be measured using Doppler. Results: In the study 10 patients did not show the sign of any calcification. Among the remaining 90 patients, 42 patients showed calcification and 48 patients showed stenosis. The statistical analysis showed a spearman correlation coefficient value of 0.201 thus showing only a weak association. Conclusion: The present study showed that only a weak relationship exists between the magnesium level and vascular calcificatio.

A Comprehensive Survey of Deep Learning: Advancements, Applications, and Challenges

Artificial intelligence's "deep learning" discipline has taken off, revolutionizing a variety of industries, from computer vision and natural language processing to healthcare and finance. Deep learning has shown extraordinary effectiveness in resolving complicated issues, and it has a wide range of potential applications, from autonomous vehicles to healthcare. The purpose of the survey to study deep learning's present condition, including recent advancements, difficulties, and constraints since the subject is currently fast growing. The basic ideas of deep learning, such as neural networks, activation functions, and optimization algorithms, are first introduced. We next explore numerous topologies, emphasizing their distinct properties and uses, including convolutional neural networks (CNNs), recurrent neural networks (RNNs), and generative adversarial networks (GANs). Further concepts, applications, and difficulties of deep learning are all covered in this survey paper's thorough review. This survey aid the academics, professionals, and individuals who want to learn more about deep learning and explore its applications to challenging situations in the real world