The Divine Clockwork: Bohr's correspondence principle and Nelson's stochastic mechanics for the atomic elliptic state

We consider the Bohr correspondence limit of the Schrodinger wave function for an atomic elliptic state. We analyse this limit in the context of Nelson's stochastic mechanics, exposing an underlying deterministic dynamical system in which trajectories converge to Keplerian motion on an ellipse. This solves the long standing problem of obtaining Kepler's laws of planetary motion in a quantum mechanical setting. In this quantum mechanical setting, local mild instabilities occur in the Kelperian orbit for eccentricities greater than 1/\sqrt{2} which do not occur classically.Comment: 42 pages, 18 figures, with typos corrected, updated abstract and updated section 6.

Measuring the Impact of Inner City Markets on CBD Retail Sales

[Excerpt] Observers of Central Business District (CBD) retailing performance have reported many adjustments in recent decades. Sales have steadily declined, relatively and absolutely, since World War II. The function and trade area of the CBD has changed, the clientele is different, and retail establishments have adopted new locational strategies. Contributing substantially to the changing character of CBDs has been the pervasive and continuing decentralization of the metropolitan population. Nearly two decades ago, Vance (1962) conceptualized the impact of this decentralization process as one of relegating the CBD to that of (1) a seller of mass appeal goods to an inner city market and (2) a seller of specialty goods to the metropolitan market. More recently, it appears that a scaling back has also occurred in the specialty goods area. Increasingly, specialty goods sales have been sustained by those who are downtown because of employment or business

Nonlinear Dynamic Behavior of Pile Groups: Effects of Plasticity of Soil

The effects of material nonlinearity of soil on dynamic behavior of a single pile and pile groups are investigated. An advanced plasticity based soil model, HiSS, is incorporated in the finite element formulation. To simulate radiation effects, proper boundary conditions are used. The model and algorithm are verified with analytical results that are available for elastic and elasto-plastic soil models. Analyses are performed for seismic excitation as well as for loads applied on the pile cap and the effect of nonlinearity is investigated. Effects of spacing between piles are investigated. It was found that the effect of soil nonlinearity on the seismic response is very much dependent on the frequency of excitation. At low frequencies, its effect is significant but at higher frequencies it is negligible. For the loading on a pile cap, the nonlinearity decreases the dynamic stiffness of the soil-pile system. Effect of nonlinearity on the dynamic stiffness is shown to be sensitive to the spacing between piles. Nonlinearity suppresses wave interference effects among piles and thus reduces the stiffness significantly at excitation frequencies where the group effect is most important

Monoamine oxidase (MAO) inhibitory effects of candidate MAO inhibitors found in cigarette smoke.

There is strong evidence that tobacco smoke inhibits both MAO A and MAO B isoforms in the body. However, which components of cigarette smoke are responsible for MAO inhibition is not clear yet. Our group has identified six previously unidentified candidate MAO inhibitors from the tobacco smoke. The MAO inhibitory effects of these candidate inhibitors were compared with that of nicotine and TPM (Tobacco Particulate Matter). An SH-SY5Y cell line was exposed to different regimens of ethanol (control), nicotine, TPM and the cocktail of candidate inhibitors. A final concentration 0.2 μM nicotine was used and the concentration of each candidate inhibitor was relative to that originally found in TPM. We found that nicotine did not have any significant MAO inhibitory effect compared to the control. TPM inhibited overall MAO activity by 39%, while the MAO inhibition by cocktail of candidate inhibitors was 47%. The results suggest that the candidate inhibitors identified by our group are the major contributors to the total MAO inhibitory activity depicted by cigarette smoke and potentially unlocks the mystery behind the components responsible for MAO inhibition by cigarette smoke in smokers

Effect of Plasticity of Soil on Seismic Response of Pile Foundation: Parametric Study

Much of the reported research on the dynamic analysis of pile foundations assumes linear behavior of soil that may not be valid at strong excitations. In this paper material nonlinearity of soil caused by plasticity and work hardening is considered for the dynamic analysis of pile foundations. An advanced plasticity based soil model, HISS, is incorporated in a finite element technique. Analysis is carried out in the time domain. The algorithm is verified with available analytical results and then linear and nonlinear responses of a single end bearing pile are compared. Effects of different frequencies of excitation (harmonic) and ratio of rigidity of soil and pile have been investigated

Unc-4 acts to promote neuronal identity and development of the take-off circuit in the Drosophila CNS

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A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo

The microtubule binding proteintau is strongly implicated in multiple neurodegenerative disorders, includingfrontotemporal dementia and parkinsonism linkedto chromosome 17 (FTDP-17), which is caused by mutations intau.In vitro, FTDP-17 mutant versions oftau can reduce microtubule binding and increase the aggregation of tau, but the mechanism by which these mutations promote disease in vivo is not clear. Here we take a combined biochemical and in vivo modeling approach to define functional properties of tau driving neurotoxicity in vivo. We express wild-type human tau and five FTDP-17 mutant forms of tau inDrosophila using a site-directed insertion strategy to ensure equivalent levels of expression. We then analyze multiple markers of neurodegeneration and neurotoxicity in transgenic animals, including analysis of both males and females. We find that FTDP-17 mutations act to enhance phosphorylation of tau and thus promote neurotoxicity in an in vivo setting. Further, we demonstrate that phosphorylation-dependent excess stabilization of the actin cytoskeleton is a key phosphorylation-dependent mediator of the toxicity of wild-type tau and of all the FTDP-17 mutants tested. Finally, we show that important downstream pathways, including autophagy and the unfolded protein response, are coregulated with neurotoxicity and actin cytoskeletal stabilization in brains of flies expressing wild-type human and various FTDP-17 tau mutants, supporting a conserved mechanism of neurotoxicity of wild-type tau and FTDP-17 mutant tau in disease pathogenesis.This work wassupported by National Institutes of Health-National Institute of Neurological Disorders and Stroke Grant R01-NS-08339

The Capaciousness of No: Affective Refusals as Literacy Practices

© 2020 The Authors. Reading Research Quarterly published by Wiley Periodicals, Inc. on behalf of International Literacy Association The authors considered the capacious feeling that emerges from saying no to literacy practices, and the affective potential of saying no as a literacy practice. The authors highlight the affective possibilities of saying no to normative understandings of literacy, thinking with a series of vignettes in which children, young people, and teachers refused literacy practices in different ways. The authors use the term capacious to signal possibilities that are as yet unthought: a sense of broadening and opening out through enacting no. The authors examined how attention to affect ruptures humanist logics that inform normative approaches to literacy. Through attention to nonconscious, noncognitive, and transindividual bodily forces and capacities, affect deprivileges the human as the sole agent in an interaction, thus disrupting measurements of who counts as a literate subject and what counts as a literacy event. No is an affective moment. It can signal a pushback, an absence, or a silence. As a theoretical and methodological way of thinking/feeling with literacy, affect proposes problems rather than solutions, countering solution-focused research in which the resistance is to be overcome, co-opted, or solved. Affect operates as a crack or a chink, a tiny ripple, a barely perceivable gesture, that can persist and, in doing so, hold open the possibility for alternative futures

Necessary and sufficient conditions for path-independence of Girsanov transformation for infinite-dimensional stochastic evolution equations

Based on a recent result on linking stochastic differential equations on ℝ d to (finite-dimensional) Burger-KPZ type nonlinear parabolic partial differential equations, we utilize Galerkin type finite-dimensional approximations to characterize the path-independence of the density process of Girsanov transformation for the infinite-dimensional stochastic evolution equations. Our result provides a link of infinite-dimensional semi-linear stochastic differential equations to infinite-dimensional Burgers-KPZ type nonlinear parabolic partial differential equations. As an application, this characterization result is applied to stochastic heat equation in one space dimension over the unit interval

Rethinking the social impacts of the arts

The paper presents a critical discussion of the current debate over the social impacts of the arts in the UK. It argues that the accepted understanding of the terms of the debate is rooted in a number of assumptions and beliefs that are rarely questioned. The paper goes on to present the interim findings of a three‐year research project, which aims to rethink the social impact of the arts, with a view to determining how these impacts might be better understood. The desirability of a historical approach is articulated, and a classification of the claims made within the Western intellectual tradition for what the arts “do” to people is presented and discussed