Kidney disease in primary anti-phospholipid antibody syndrome

APS is an autoimmune disease defined by the presence of arterial or venous thrombotic events and/or pregnancy morbidity in patients who test positive for aPL. APS can be isolated (primary APS) or associated with other autoimmune diseases. The kidney is a major target organ in APS, and renal thrombosis can occur at any level within the vasculature of the kidney (renal arteries, intrarenal vasculature and renal veins). Histological findings vary widely, including ischaemic glomeruli and thrombotic lesions without glomerular or arterial immune deposits on immunofluorescence. Renal involvement in patients with definite APS is treated with long-term anticoagulants as warfarin, but new treatments are being tried. The aim of this article is to review the links between primary APS and kidney disease

Physical Properties, Star Formation, and Active Galactic Nucleus Activity in Balmer Break Galaxies at 0 < z < 1

We present a spectroscopic study with the derivation of the physical properties of 37 Balmer break galaxies, which have the necessary lines to locate them in star-forming-AGN diagnostic diagrams. These galaxies span a redshift range from 0.045 to 0.93 and are somewhat less massive than similar samples of previous works. The studied sample has multiwavelength photometric data coverage from the ultraviolet to MIR Spitzer bands. We investigate the connection between star formation and AGN activity via optical, mass-excitation (MEx) and MIR diagnostic diagrams. Through optical diagrams, 31 (84%) star-forming galaxies, 2 (5%) composite galaxies and 3 (8%) AGNs were classified, whereas from the MEx diagram only one galaxy was classified as AGN. A total of 19 galaxies have photometry available in all the IRAC/Spitzer bands. Of these, 3 AGN candidates were not classified as AGN in the optical diagrams, suggesting they are dusty/obscured AGNs, or that nuclear star formation has diluted their contributions. Furthermore, the relationship between SFR surface density (\Sigma_{SFR}) and stellar mass surface density per time unit (\Sigma_{M_{\ast}/\tau}) as a function of redshift was investigated using the [OII] \lambda3727, 3729, H\alpha \lambda6563 luminosities, which revealed that both quantities are larger for higher redshift galaxies. We also studied the SFR and SSFR versus stellar mass and color relations, with the more massive galaxies having higher SFR values but lower SSFR values than less massive galaxies. These results are consistent with previous ones showing that, at a given mass, high-redshift galaxies have on average larger SFR and SSFR values than low-redshift galaxies. Finally, bluer galaxies have larger SSFR values than redder galaxies and for a given color the SSFR is larger for higher redshift galaxies.Comment: preprint version, 36 pages, 17 figures, 3 tables, accepted for publication in the Astrophysical Journa

f(R) wormholes embedded in a pseudo--Euclidean space E5E^{5}

This work is devoted to the study of analytic wormhole solutions within the framework of $f(R)$ gravity theory. To check the possibility of having wormhole structures satisfying energy conditions, by means of the class I approach the pair $\{\Phi(r), b(r)\}$ describing the wormhole geometry has been obtained. Then, in conjunction with a remarkably $f(R)$ gravity model, the satisfaction of the null and weak energy conditions at the wormhole throat and its neighborhood is investigated. To do so, some constant parameters have been bounded restricting the space parameter. In this concern, the $f(R)$ gravity model and its derivatives are playing a major role, specially in considering the violation of the non--existence theorem. Furthermore, the shape function should be bounded from above by the Gronwall--Bellman shape function, where the red--shift function plays a relevant role. By analyzing the main properties at the spatial stations and tidal accelerations at the wormhole throat, possibilities and conditions for human travel are explored.Comment: 20 pages, 21 figure

Minimally deformed wormholes inspired by noncommutative geometry

In this article, new wormhole solutions in the framework of General Relativity are presented. Taking advantage of gravitational decoupling by means of minimal geometric deformation approach and, the so-called noncommutative geometry Gaussian and Lorentzian density profiles, the seminal Morris-Thorne space-time is minimally deformed providing new asymptotically wormhole solutions. Constraining the signature of some parameters, the dimensionless constant $\alpha$ is bounded using the flare-out and energy conditions. In both cases, this results in an energy-momentum tensor that violates energy conditions, thus the space-time is threading by exotic matter. However, it is possible to obtain a positive defined density at the wormhole throat and its neighborhood. To further support the study a thoroughly graphical analysis has been performed.Comment: 20 pages, 6 figures. Accepted Version Fortschritte der physi

Cloud Computing Based Network Analysis in Smart Healthcare System with Neural Network Architecture

The recent progressions in Artificial Intelligence (AI), the Internet of Things (IoT), and cloud computing transformed the traditional healthcare system into a smart healthcare system. Medical services can be improved through the incorporation of key technologies namely AI and IoT. The convergence of AI and IoT renders several openings in the healthcare system. In machine learning, deep learning can be considered a renowned topic with a wide range of applications like biomedicine, computer vision, speech recognition, drug discovery, visual object detection, natural language processing, disease prediction, bioinformatics, etc. Among these applications, medical science-related and health care applications were raised dramatically. This study develops a Cloud computing-based network analysis in the smart healthcare systems with neural network (CCNA-SHSNN) architecture. The presented CCNA-SHSNN technique assists in the decision-making process of the healthcare system in a real time cloud environment. For data pre-processing, the CCNA-SHSNN technique uses a normalization approach. Secondly, the CCNA-SHSNN technique applies the autoencoder (AE) model for healthcare data classification in the CC platform. At last, the gravitational search algorithm (GSA) is used for hyperparameter optimization of the AE model. The experimental outcomes are determined on a benchmark dataset and the outcomes signify the outperforming efficiency of the CCNA-SHSNN technique compared to existing techniques

The afterglow and kilonova of the short GRB 160821B

GRB 160821B is a short duration gamma-ray burst (GRB) detected and localized by the Neil Gehrels Swift Observatory in the outskirts of a spiral galaxy at z=0.1613, at a projected physical offset of 16 kpc from the galaxy's center. We present X-ray, optical/nIR and radio observations of its counterpart and model them with two distinct components of emission: a standard afterglow, arising from the interaction of the relativistic jet with the surrounding medium, and a kilonova, powered by the radioactive decay of the sub-relativistic ejecta. Broadband modeling of the afterglow data reveals a weak reverse shock propagating backward into the jet, and a likely jet-break at 3.5 d. This is consistent with a structured jet seen slightly off-axis while expanding into a low-density medium. Analysis of the kilonova properties suggests a rapid evolution toward red colors, similar to AT2017gfo, and a low nIR luminosity, possibly due to the presence of a long-lived neutron star. The global properties of the environment, the inferred low mass (M_ej < 0.006 Msun) and velocities (v > 0.05 c) of lanthanide-rich ejecta are consistent with a binary neutron star merger progenitor.Comment: 14 pages, 6 figures, MNRAS, in press. Moderate revision, added Figure 5 and X-ray data to Table

Galaxies behind the Galactic plane: First results and perspectives from the VVV Survey

Vista Variables in The Via Lactea (VVV) is an ESO variability survey that is performing observations in near infrared bands (ZYJHKs) towards the Galactic bulge and part of the disk with the completeness limits at least 3 mag deeper than 2MASS. In the present work, we searched in the VVV survey data for background galaxies near the Galactic plane using ZYJHKs photometry that covers 1.636 square degrees. We identified 204 new galaxy candidates by analyzing colors, sizes, and visual inspection of multi-band (ZYJHKs) images. The galaxy candidates colors were also compared with the predicted ones by star counts models considering a more realistic extinction model at the same completeness limits observed by VVV. A comparison of the galaxy candidates with the expected one by Milennium simulations is also presented. Our results increase the number density of known galaxies behind the Milky Way by more than one order of magnitude. A catalog with galaxy properties including ellipticity, Petrosian radii and ZYJHKs magnitudes is provided, as well as comparisons of the results with other surveys of galaxies towards Galactic plane.Comment: 27 pages, 10 figures, 2 tables; in press at The Astronomical Journa

Cardiac abnormalities in the toxic oil syndrome, with comparative observations on the eosinophilia-myalgia syndrome

AbstractEarly in the course of studies of the Spanish toxic oil syndrome it was recognized that vascular lesions were a major problem, most logically attributable to endothelial damage by the toxic oil. However, most clinical attention has been directed to the pulmonary complications and the evolution into a scleroderma-like illness later. p]In this study of 11 victims of the toxic oil syndrome careful postmortem studies of the coronary arteries and conduction system and neural structures of the heart demonstrated major injury to all those components of the heart. Obliterative fibrosis of the sinus node in four cases resembled findings in fatal scleroderma heart disease, and in eight the cardiac lesions resembled those of lupus erythematosus.The more impressive pathologic features involved the coronary arteries and neural structures, which were abnormal in every heart. The arterial disease included widespread focal fibromuscular dysplasia, but there was also an unusual myointimal proliferative degeneration of both small and large coronary arteries in five patients, four of whom were young women. In two hearts, portions of the inner wall of the sinus node artery had actually detached and embolized downstream. Coronary arteritis was rarely found. Inflammatory and noninflammatory degeneration of cardiac nerves was widespread. Fatty infiltration, fibrosis and degeneration were present in the coronary chemoreceptor.In most respects these cardiac abnormalities resemble those described in the eosinophilia-myalgia syndrome caused by an altered form of l-tryptophan. In both diseases there is good reason to anticipate more clinical cardiac difficulties than have so far been reported, and even more basis for future concern, especially relative to coronary disease and cardiac electrical instability