The Economic Impact of Social Ties: Evidence from German Reunification

We use the fall of the Berlin Wall in 1989 to show that personal relationships which individuals maintain for non-economic reasons can be an important determinant of regional economic growth. We show that West German households who have social ties to East Germany in 1989 experience a persistent rise in their personal incomes after the fall of the Berlin Wall. Moreover, the presence of these households significantly affects economic performance at the regional level: it increases the returns to entrepreneurial activity, the share of households who become entrepreneurs, and the likelihood that firms based within a given West German region invest in East Germany. As a result, West German regions which (for idiosyncratic reasons) have a high concentration of households with social ties to the East exhibit substantially higher growth in income per capita in the early 1990s. A one standard deviation rise in the share of households with social ties to East Germany in 1989 is associated with a 4.6 percentage point rise in income per capita over six years. We interpret our findings as evidence of a causal link between social ties and regional economic development.economic development, German reuni cation, networks, social ties

The Impact of Stealthy Attacks on Smart Grid Performance: Tradeoffs and Implications

The smart grid is envisioned to significantly enhance the efficiency of energy consumption, by utilizing two-way communication channels between consumers and operators. For example, operators can opportunistically leverage the delay tolerance of energy demands in order to balance the energy load over time, and hence, reduce the total operational cost. This opportunity, however, comes with security threats, as the grid becomes more vulnerable to cyber-attacks. In this paper, we study the impact of such malicious cyber-attacks on the energy efficiency of the grid in a simplified setup. More precisely, we consider a simple model where the energy demands of the smart grid consumers are intercepted and altered by an active attacker before they arrive at the operator, who is equipped with limited intrusion detection capabilities. We formulate the resulting optimization problems faced by the operator and the attacker and propose several scheduling and attack strategies for both parties. Interestingly, our results show that, as opposed to facilitating cost reduction in the smart grid, increasing the delay tolerance of the energy demands potentially allows the attacker to force increased costs on the system. This highlights the need for carefully constructed and robust intrusion detection mechanisms at the operator.Comment: Technical report - this work was accepted to IEEE Transactions on Control of Network Systems, 2016. arXiv admin note: substantial text overlap with arXiv:1209.176

High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion

Background and aim: Perivascular adipose tissue (PVAT) positively regulates vascular function through production of factors such as adiponectin but this effect is attenuated in obesity. The enzyme AMP-activated protein kinase (AMPK) is present in PVAT and is implicated in mediating the vascular effects of adiponectin. In this study, we investigated the effect of an obesogenic high fat diet (HFD) on aortic PVAT and whether any changes involved AMPK. Methods: Wild type Sv129 (WT) and AMPKα1 knockout (KO) mice aged 8 weeks were fed normal diet (ND) or HFD (42% kcal fat) for 12 weeks. Adiponectin production by PVAT was assessed by ELISA and AMPK expression studied using immunoblotting. Macrophages in PVAT were identified using immunohistochemistry and markers of M1 and M2 macrophage subtypes evaluated using real time-qPCR. Vascular responses were measured in endothelium-denuded aortic rings with or without attached PVAT. Carotid wire injury was performed and PVAT inflammation studied 7 days later. Key results: Aortic PVAT from KO and WT mice was morphologically indistinct but KO PVAT had more infiltrating macrophages. HFD caused an increased infiltration of macrophages in WT mice with increased expression of the M1 macrophage markers Nos2 and Il1b and the M2 marker Chil3. In WT mice, HFD reduced the anticontractile effect of PVAT as well as reducing adiponectin secretion and AMPK phosphorylation. PVAT from KO mice on ND had significantly reduced adiponectin secretion and no anticontractile effect and feeding HFD did not alter this. Wire injury induced macrophage infiltration of PVAT but did not cause further infiltration in KO mice. Conclusions: High-fat diet causes an inflammatory infiltrate, reduced AMPK phosphorylation and attenuates the anticontractile effect of murine aortic PVAT. Mice lacking AMPKα1 phenocopy many of the changes in wild-type aortic PVAT after HFD, suggesting that AMPK may protect the vessel against deleterious changes in response to HFD

The role of lipids in drug absorption throught the GIT

Os vectores lipídicos apresentam inúmeras vantagens para a administração oral de substâncias farmacológicas, p.ex. são compostos por moléculas lipídicas semelhantes àquelas que figuram nos tecidos humanos, tornando-se biocompatíveis, biotoleráveis e biodegradáveis. São exemplos as tradicionais emulsões O/A, as suspensões de nanopartículas lipídicas (SLNs e NLC s) e, recentemente, as SolEmuls®, que permitem localizar fármacos fracamente solúveis em ambas as fases das emulsões, na camada interfacial de lecitina. Este artigo aborda o papel dos lípidos no aumento da absorção e da biodisponibilidade de fármacos administrados oralmente. Lipid carriers show several advantages for oral delivery of pharmacologically active drugs, e.g. are composed of lipid molecules similar to those in human tissues, becoming therefore biocompatible, biotolerable and biodegradable. Examples include traditional o/w emulsions, suspensions of lipid nanoparticles (SLNs and NLC s) and, recently, the SolEmuls®, which allows localizing poorly soluble drug molecules both in oil and aqueous phases, in the interfacial layer of lecithin. This paper reports on the role of lipids in enhancing both drug absorption and bioavailability when administered orally

The "zeroth law" of turbulence: Isotropic turbulence simulations revisited

The dimensionless kinetic energy dissipation rate C_epsilon is estimated from numerical simulations of statistically stationary isotropic box turbulence that is slightly compressible. The Taylor microscale Reynolds number Re_lambda range is 20 < Re_lambda < 220 and the statistical stationarity is achieved with a random phase forcing method. The strong Re_lambda dependence of C_epsilon abates when Re_lambda approx. 100 after which C_epsilon slowly approaches approx 0.5 a value slightly different to previously reported simulations but in good agreement with experimental results. If C_epsilon is estimated at a specific time step from the time series of the quantities involved it is necessary to account for the time lag between energy injection and energy dissipation. Also, the resulting value can differ from the ensemble averaged value by up to +-30%. This may explain the spread in results from previously published estimates of C_epsilon.Comment: 7 pages, 7 figures. Submitted to Phys. Rev.

Case Studies in Web-Controlled Devices and Remote Manipulation

The concept of distance learning has been more and more articulated during the past few years and is expected to shortly turn into a practical education system within current high level learning institutions. The chances are that distance learning would transparently extend colleges and institutes of education, and could plausibly overtake and turn into a preferred choice of higher education, especially for adult and working students. The concept would be unachievable without the current technology, for example, the impressive worldwide accessibility of the Internet. The main idea in e-learning is to build adequate solutions that could assure educational training over the Internet, without requiring a personal presence at the degree offering institution. For example, being able to obtain a Bachelor’s degree in Computer Engineering from an accredited institution while residing thousands of miles away from it and actually never seeing it, except maybe for the graduation ceremony. The advantages are immediate and of unique importance, to enumerate a few: Scholarship / education costs can be reduced dramatically, both from a student’s perspective and the institution’s (no need for room and board, for example); The usually tedious immigration and naturalization issues that are common with international students are eliminated; The limited campus facilities, faculty members and course schedules an institution can offer are no longer a boundary; Working adults can consider upgrading skills without changing their lifestyle

Strong Approximation of Empirical Copula Processes by Gaussian Processes

We provide the strong approximation of empirical copula processes by a Gaussian process. In addition we establish a strong approximation of the smoothed empirical copula processes and a law of iterated logarithm

Renormalisation and fixed points in Hilbert Space

The energies of low-lying bound states of a microscopic quantum many-body system of particles can be worked out in a reduced Hilbert space. We present here and test a specific non-perturbative truncation procedure. We also show that real exceptional points which may be present in the spectrum can be identified as fixed points of coupling constants in the truncation procedure.Comment: 4 pages, 1 tabl