DDAO Controlled Synthesis of Organo-Modified Silica Nanoparticles with Encapsulated Fluorescent Boron Dipyrrins and Study of Their Uptake by Cancerous Cells

The design of cargo carriers with high biocompatibility, unique morphological characteristics, and capability of strong bonding of fluorescent dye is highly important for the development of a platform for smart imaging and diagnostics. In this paper, BODIPY-doped silica nanoparticles were prepared through a "one-pot" soft-template method using a sol-gel process. Several sol-gel precursors have been used in sol-gel synthesis in the presence of soft-template to obtain the silica-based materials with the most appropriate morphological features for the immobilization of BODIPY molecules. Obtained silica particles have been shown to be non-cytotoxic and can be effectively internalized into the cervical cancer cell line (HeLa). The described method of synthesis allows us to obtain silica-based carriers with an immobilized fluorescent dye that provide the possibility for real-time imaging and detection of these carriers

Pharmacokinetics of dipeptide mimetic BDNF GSB-106 in rats

Pharmacokinetics of the GSB-106 in variety of administration ways in rats was studied. After single oral administration the test substance was determined for 4 h in the blood plasma. Half-life was 0.65 h. The GSB-106 tissue availability in high-vascularized organs (liver, kidney, spleen) was over then skeletal muscle. In brain (target-organ) that parameter was 0.05. In the 24-hour urine the parent compound was not detected and in the feces were determined of 0.0001 % GSB-106 after oral administration in dose 150 mg/kg. The absolute bioavailability of GSB-106 was 5.6 %

ПОТЕНЦИАЛЬНЫЕ ВОЗМОЖНОСТИ ПОВЫШЕНИЯ УРОЖАЙНОСТИ ПШЕНИЦЫ НА ЭРОДИРОВАННЫХ ПОЧВАХ ПРИ ИСПОЛЬЗОВАНИИ ФОСФАТМОБИЛИЗУЮЩЕГО ИНОКУЛЯНТА

The field experiment data show that application of phosphorus-solubilizing inoculant increases spring wheat and winter wheat yields at different slope elements – watershed, medium and severely eroded soils. The yield increase is caused by multifunctionality of phosphorus-solubilizing inoculant which possesses the properties of plant growth promoter, biofertilizer and biopesticide as well. Quantitative parameters of the influence of phosphorus-solubilizing inoculant on the yield and phytopathological state of crops are presented.В полевом эксперименте на дерново-подзолистых почвах на моренных суглинках установлено, что применение фосфатмобилизующего инокулянта повышало урожайность яровой и озимой пшеницы на разных элементах склона: водоразделе, средне- и сильноэродированных почвах. Повышение урожайности обусловлено полифункциональностью микробного инокулянта, сочетающего свойства регулятора роста, биоудобрения и биопестицида. Установлены количественные показатели влияния фосфатмобилизующего инокулянта на урожайность и фитопатологическое состояние посевов

Фармакокинетика дипептидного миметика BDNF ГСБ-106 у крыс

Pharmacokinetics of the GSB-106 in variety of administration ways in rats was studied. After single oral administration the test substance was determined for 4 h in the blood plasma. Half-life was 0.65 h. The GSB-106 tissue availability in high-vascularized organs (liver, kidney, spleen) was over then skeletal muscle. In brain (target-organ) that parameter was 0.05. In the 24-hour urine the parent compound was not detected and in the feces were determined of 0.0001 % GSB-106 after oral administration in dose 150 mg/kg. The absolute bioavailability of GSB-106 was 5.6 %.На крысах изучена фармакокинетика соединения ГСБ-106 после различных способов введения. После однократного перорального введения исследуемое вещество в организме крыс определяется на протяжении 4 ч. Период полуэлиминации составил 0,65 ч. Показано, что тканевая доступность ГСБ-106 в хорошо васкуляризированных органах (печень, почки, селезёнка) выше, чем в скелетной мускулатуре крыс. В органе-мишени - мозге данный показатель составил 0,05. После однократного перорального введения ГСБ-106 крысам в дозе 150,0 мг/кг в суточной моче исходное соединение не обнаружено, а в кале обнаружено 0,0001 % ГСБ-106 от введённой дозы. Абсолютная биодоступность соединения ГСБ-106 у крыс составила 5,6 %

Women’s Comics in Russia: Initiated by Manga

In the USSR, like in many other countries, comics were mostly seen as light reading material and published in children’s magazines. When a comics market formed in Russia during the 1990s, it consisted mainly of translated American and European children’s comics, but first comics-only magazines aimed at teenagers and adults also appeared at that time (KOM, Veles, Muha, etc.). These magazines presented works made by men and for men, usually containing sexualized images of women. There were no famous women among Russian comic artists during the 1990s, as female authors usually assisted their husbands or were known as part of comics artists duos. An example of the latter is Natalia Snegireva, who created “Keshka”, a children’s comics series about a cat, together with her husband Andrey. Another person is Svetlana Sorokina, who helped her husband Evgeny as a colorist and then designed book covers for the Russian edition of “ElfQuest” by Wendy and Richard Piny. The turning point for female comics artists in Russia came in the early 2000s with the growing popularity of Japanese manga and the spread of the Internet. Due to these factors, young women published comics in new magazines aimed at both children and teenagers (Klassnyi zhurnal, Yula, etc.) and at anime fans (Poppuri anime, Anime Guide, etc.). For example, Lina and Kotyonok (“The Kitten”) by Enji were a romance and fantasy comics series with a girl as protagonist; Rytsari radugi (“The Knights of the Rainbow”) from Yula magazine examined “girl power” through the friendship between girls and magic adventures of Russian middle school students. Female artists who adopted the style of Japanese manga were not the only ones to open the door for new themes in comics and imagine girls as heroines, but their work definitely encouraged young girls to draw comics by themselves and participate in Russian comics festivals. This article examines the role of manga, shōjo manga (comics for girls) in particular, for the birth of women’s comics in Russia and feminist themes. Its influence on the growth of women in comics both as readers and artists, the appearance of manga-inspired comics which address issues such as women’s body and trauma Kniga tela (“The Book of Body”) or Razdelenie (“Partition”) by Yuliya Nikitina; lesbian romance Klub by Anna Rud’; life of a young woman during the siege of Leningrad Survilo by Olga Lavrentieva. Besides representational contents, the birth of feminist fanzines such as those by Nika Vodvud and group “FemInfoteka” are also noteworthy

Scientific research of the Institute of Nuclear Medicine and Diagnostic Radiology of the National Academy of Medical Sciences of Ukraine in 2020: hepatology, oncology and intellectual data processing

The main results of the scientific activity of the Institute in 2020 are presented: the study of the structural features of diagnostic images based on their heterogeneity for the purpose of differential diagnosis of malignant neoplasms; development of radiation diagnostic criteria for differential diagnosis of congenital and acquired liver diseases in children; development of urgent detailed ultrasound examinations for traumatic injuries of the human body, complex radiation examination of the wound channel in case of a gunshot injury; development of methodological foundations for the use of multiparametric high-field MRI of the brain to assess the state of the leading tracts and the functional capacity of the cerebral cortex. Methods for textural analysis of computed tomographic images, echograms of normal and tumor tissues based on the use of coefficients of one-dimensional heterogeneity, anisotropy coefficient, and verticality coefficient have been developed. For the first time in Ukraine, a mathematical system that provides in 93-98% of cases of recognition of fibrous (precision) liver changes based on ultrasound images (utility model patent No. 139916) has been developed; significant differences between the values of mathematical criteria for normal and damaged liver based on computer processing of echographic images allow solving the problem of recognizing diffuse liver diseases.</jats:p

Diagnostic imaging in obstetrics (Lecture)

Summarizing the variety of diagnostic imaging methods in obstetrics, there are next main offensive positions. Urgent indications for CT during pregnancy. Appendicitis – during pregnancy of the first and second trimesters. Ultrasound and/or MRI should be performed before CT. Pulmonary artery thromboembolism – in this case low-dose CT angiography of the lungs (with X-ray protection of the fetus). If suspected – CT should be the primary method of examination. In renal colic, ultrasound is the method of choice. In case of injury, ultrasound may be sufficient for the initial assessment in pregnant women, but CT should be performed if more severe or polytrauma is suspected. All patients who undergo CT of the abdomen or pelvis during pregnancy must sign a written personal consent form. In a study that presents a minimal risk (including CT pelviometry, CT of other areas of the body and MRI), it is advisable to explain to the pregnant woman about the minimal risk. Intravenous gadolinium is contraindicated in pregnancy and should be used only when absolutely necessary. Pelviometry can be performed either by low-dose CT or by MRI. Key words: pregnant women, fetuses, ultrasound (ultrasound diagnostics), MRI (magnetic resonance imaging), CT (X-ray computed tomography).</jats:p

Perinatal predictors and ultrasound diagnostics of newborn respiratory disorders

Respiratory distress is one of the most common causes of neonatal morbidity and mortality. The aim of this study was to determine perinatal factors and ultrasonographic features of newborn respiratory disorders. We examined 49 children aged 0-28 days who had manifestations of type 1 RDS (group 1 – 24 children) and pneumonia caused by intrauterine infection or massive meconium aspiration syndrome (group 2 – 25 children). The control group consisted of 20 newborn. The control group consisted of 20 newborns. Data analysis showed that the presence of extra genital pathology that had mother, significantly influenced on the development of respiratory disorders (group 1 – 75 % ,and group 2 – 60 % compared to the control group – 20 %), as well as a high frequency of chronic fetal hypoxia and placental dysfunction complicated by fetal distress (in group 1 – 75 % of cases, in group 2 – 40 %) It was found that ultrasound examination of the lungs is an informative, safe method for diagnosing pneumonia, pneumothorax, the presence of fluid in the pleural cavity of newborn respiratory disorders, and provides an opportunity to monitor pathological changes during treatment.</jats:p

Ультразвукові прояви аутосомно-рецесивної полікістозної хвороби нирок у дітей

Objective — to evaluate the results of a comprehensive study echographic kidney and liver in children with autosomal recessive polycystic kidney disease.Patients and methods. A total of 9 children with this pathology in age from 3 to 16 years. The median age was 6,2 ± 2,3 years. The boy was 7, girls — 2. Sonographic study was conducted according to standard protocols for devices Acuson X300 (Siemens, Germany), MyLab Class C (ESAOTE, Italy). Convex used multifrequency 2–5 MHz. For the purpose of detailed study of the renal parenchyma and liver used high_frequency sensors scan 10 MHz.Results. When sonographic study of all cases revealed a combined kidney and liver. If changes in liver ehogepatografii fit into the picture of fibrotic changes of varying severity. All patients had bilateral renal, kidney size indicators were greater age from 50 to 75%. The contours of the kidney were equal, precise. Differentiation parenchymal layer and pyelocaliceal system practically determined.Conclusions. In all cases with complex sonographic study found structural changes in the kidney and liver, as well as changes in the indices of regional renal and hepatic blood flow.Key words: autosomic recessive policystic kidney disease, liver fibrosis, children, echography.Цель — оценить результаты комплексного эхографического исследования почек и печени у детей с аутосомно-рециссивной поликистозной болезнью почек.Пациенты и методы. Обследовано 9 детей с данной патологией в возрасте от 3 до 16 лет. Средний возраст составил 6,2±2,3 года. Мальчиков было 7, девочек — 2. Сонографическое исследование проведено согласно стандартным протоколам на аппаратах Acuson X300 (Siemens, Германия), MyLab Class C (ESAOTЕ, Италия). Использованы мультичастотные конвексные 2–5 МГц. С целью детального изучения паренхимы почек и печени использовано высокочастотное сканирование датчиками 10 МГц.Результаты. При эхографическом исследовании во всех случаях выявлено сочетанное поражение почек и печени. При эхогепатографии изменения в печени укладывались в картину фиброзных изменений разной степени выраженности. У всех пациентов поражение почек было двухсторонним, размеры почек были больше возрастных показателей от 50 до 75%. Контуры почек были ровными, четкими. Дифференциация паренхиматозного слоя и чашечно-лоханочной системы практически не определялась.Выводы. Во всех наблюдениях при комплексном эхографическом исследовании обнаружены структурные изменения в почках и печени, а также изменения показателей регионарного почечного и печеночного кровотока.Ключевые слова: аутосомно-рецессивная поликистозная болезнь почек, врожденный фиброз печени, дети, эхографическое исследование.Мета — оцінити результати комплексного ехографічного дослідження нирок і печінки в дітей з аутосомно-рецесивною полікістозною хворобою нирок.Пацієнти та методи. Обстежено 9 дітей з даною патологією у віці від 3 до 16 років. Середній вік становив 6,2±2,3 року. Хлопчиків було 7, дівчаток — 2. Сонографічне дослідження проведено відповідно до стандартних протоколів на аппаратах Acuson X300 (Siemens, Німеччина), MyLab Class C (ESAOTЕ, Італія). Використано мультичастотні конвексні 2–5 МГц. З метою детального вивчення паренхіми нирок і печінки високочастотне сканування датчиками 10 МГц.Результати. При ехографічному дослідженні у всіх випадках виявлено поєднане ураження нирок і печінки. При ехогепатографії зміни в печінці вкладалися в картину фіброзних змін різного ступеня вираженості. У всіх пацієнтів ураження нирок було двостороннім. Розміри нирок більші за вікові показники від 50 до 75%. Контури нирок були рівними, чіткими. Диференціація паренхіматозного шару і чашково-мискової системи практично не визначалася.Висновки. У всіх спостереженнях при комплексному ехографічному дослідженні виявлялися структурні зміни в нирках і печінці, а також зміни показників регіонарного ниркового та печінкового кровотоку.Ключові слова: аутосомно-рецесивна полікістозна хвороба нирок, вроджений фіброз печінки, діти, ехографічне дослідження