Alfven modes driven non-linearly by metric perturbations in anisotropic magnetized cosmologies

We consider anisotropic magnetized cosmologies filled with conductive plasma fluid and study the implications of metric perturbations that propagate parallel to the ambient magnetic field. It is known that in the first order (linear) approximation with respect to the amplitude of the perturbations no electric field and density perturbations arise. However, when we consider the non-linear coupling of the metric perturbations with their temporal derivatives, certain classes of solutions can induce steeply increasing in time electric field perturbations. This is verified both numerically and analytically. The source of these perturbations can be either high-frequency quantum vacuum fluctuations, driven by the cosmological pump field, in the early stages of the evolution of the Universe or astrophysical processes or a non-linear isotropization process of an initially anisotropic cosmological spacetime.Comment: 7 pages, RevTex, 3 figures ps, accepted for publication to IJMP

Designing an Experimental and a Reference Robot to Test and Evaluate the Impact of Cultural Competence in Socially Assistive Robotics

The article focusses on the work performed in preparation for an experimental trial aimed at evaluating the impact of a culturally competent robot for care home assistance. Indeed, it has been estabilished that the user's cultural identity plays an important role during the interaction with a robotic system and cultural competence may be one of the key elements for increasing capabilities of socially assistive robots. Specifically, the paper describes part of the work carried out for the definition and implementation of two different robotic systems for the care of older adults: a culturally competent robot, that shows its awareness of the user's cultural identity, and a reference robot, non culturally competent, but with the same functionalities of the former. The design of both robots is here described in detail, together with the key elements that make a socially assistive robot culturally competent, which should be absent in the non-culturally competent counterpart. Examples of the experimental phase of the CARESSES project, with a fictional user are reported, giving a hint of the validness of the proposed approach

Plasma waves driven by gravitational waves in an expanding universe

In a Friedmann-Robertson-Walker (FRW) cosmological model with zero spatial curvature, we consider the interaction of the gravitational waves with the plasma in the presence of a weak magnetic field. Using the relativistic hydromagnetic equations it is verified that large amplitude magnetosonic waves are excited, assuming that both, the gravitational field and the weak magnetic field do not break the homogeneity and isotropy of the considered FRW spacetime.Comment: 14 page

Gravito-magnetic instabilities in anisotropically expanding fluids

Gravitational instabilities in a magnetized Friedman - Robertson - Walker (FRW) Universe, in which the magnetic field was assumed to be too weak to destroy the isotropy of the model, are known and have been studied in the past. Accordingly, it became evident that the external magnetic field disfavors the perturbations' growth, suppressing the corresponding rate by an amount proportional to its strength. However, the spatial isotropy of the FRW Universe is not compatible with the presence of large-scale magnetic fields. Therefore, in this article we use the general-relativistic (GR) version of the (linearized) perturbed magnetohydrodynamic equations with and without resistivity, to discuss a generalized Jeans criterion and the potential formation of density condensations within a class of homogeneous and anisotropically expanding, self-gravitating, magnetized fluids in curved space-time. We find that, for a wide variety of anisotropic cosmological models, gravito-magnetic instabilities can lead to sub-horizonal, magnetized condensations. In the non-resistive case, the power spectrum of the unstable cosmological perturbations suggests that most of the power is concentrated on large scales (small k), very close to the horizon. On the other hand, in a resistive medium, the critical wave-numbers so obtained, exhibit a delicate dependence on resistivity, resulting in the reduction of the corresponding Jeans lengths to smaller scales (well bellow the horizon) than the non-resistive ones, while increasing the range of cosmological models which admit such an instability.Comment: 10 pages RevTex, 4 figures, accepted for publication in the International Journal of Modern Physics

A systematic review of the literature regarding socially assistive robots in pre-tertiary education

With rapid advances in Artificial Intelligence (AI) over the last decade, schools have increasingly employed innovative tools, intelligent applications and methods that are changing the education system with the aim of improving both user experience and learning gain in the classrooms. Even though the use of AI to education is not new, it has not unleashed its full potential yet. Much of the available research looks at educational robotics and at non-intelligent robots in education. Only recently, research has sought to assess the potential of Socially Assistive Robots (SARs), including humanoids, within the domain of classroom learning, particularly in relation to learning languages. Yet, the use of this form of AI in the field of mathematics and science constitutes a notable gap in this field. This study aims to critically review the research on the use of SARs in the pre-tertiary classroom teaching of mathematics and science. Further aim is to identify the benefits disadvantages of such technology. Databases' search conducted between January and April 2018 yielded twenty-one studies meeting the set inclusion criteria for our systematic review. Findings were grouped into four major categories synthesising current evidence of the contribution of SARs in pre- tertiary education: learning gain, user experience, attitude, and usability of SARs within classroom settings. Overall, the use of SARs in pre-tertiary education is promising, but studies focussing on mathematics and science are significantly under-represented. Further evidence is also required around SARs' specific contributions to learning more broadly, as well as enabling/impeding factors, such as SAR's personalisation and appearance, or the role of families and ethical considerations. Finally, SARs potential to enhance accessibility and inclusivity of multi-cultural pre-tertiary classroom is almost unexplored

Comparability of Microarray Data between Amplified and Non Amplified RNA in Colorectal Carcinoma

Microarray analysis reaches increasing popularity during the investigation of prognostic gene clusters in oncology. The standardisation of technical procedures will be essential to compare various datasets produced by different research groups. In several projects the amount of available tissue is limited. In such cases the preamplification of RNA might be necessary prior to microarray hybridisation. To evaluate the comparability of microarray results generated either by amplified or non amplified RNA we isolated RNA from colorectal cancer samples (stage UICC IV) following tumour tissue enrichment by macroscopic manual dissection (CMD). One part of the RNA was directly labelled and hybridised to GeneChips (HG-U133A, Affymetrix), the other part of the RNA was amplified according to the ?Eberwine? protocol and was then hybridised to the microarrays. During unsupervised hierarchical clustering the samples were divided in groups regarding the RNA pre-treatment and 5.726 differentially expressed genes were identified. Using independent microarray data of 31 amplified vs. 24 non amplified RNA samples from colon carcinomas (stage UICC III) in a set of 50 predictive genes we validated the amplification bias. In conclusion microarray data resulting from different pre-processing regarding RNA pre-amplification can not be compared within one analysis

Brane Cosmology from Heterotic String Theory

We consider brane cosmologies within the context of five-dimensional actions with O(a') higher curvature corrections. The actions are compatible with bulk string amplitude calculations from heterotic string theory. We find wrapped solutions that satisfy the field equations in an approximate but acceptable manner given their complexity, where the internal four-dimensional scale factor is naturally inflating, having an exponential De-Sitter form. The temporal dependence of the metric components is non-trivial so that this metric cannot be factored as in a conformally flat case. The effective Planck mass is finite and the brane solutions localize four-dimensional gravity, while the four-dimensional gravitational constant varies with time. The Hubble constant can be freely specified through the initial value of the scalar field, to conform with recent data.Comment: 15 pages, 3 figures, LaTeX, Accepted for Publication in IJT

How do firms open up the front-end of service innovation? A case study of IT-based service firms in Thailand

This paper focuses on openness in the front-end phase of service innovation and its impact on innovation success. The early stages of innovation are fuzzy and unstructured, thus often being called “fuzzy front-end” (FFE) by scholars. The FFE begins when an opportunity is considered worthy of further ideation, exploration, and assessment and ends when a firm decides to invest in – or terminate – an idea. Although openness has been identified as pivotal to innovation performance, little effort has been put into exploring its role in the early phase of innovation. By drawing on the data of a multiple case study in Thai online service firms, we are able to identify four key dimensions of FFE openness competence: prior related knowledge, top management support, the presence of workable prototype, and slack resource. Furthermore, we found three openness activities often take place in the FFE phase of successful online service innovation, i.e., external search, inter-firm partnerships and customer experimentation. From a managerial perspective, our study provides useful insights to innovation managers aiming at enhancing front-end performance through openness

The topology of U-duality (sub-)groups

We discuss the topology of the symmetry groups appearing in compactified (super-)gravity, and discuss two applications. First, we demonstrate that for 3 dimensional sigma models on a symmetric space G/H with G non-compact and H the maximal compact subgroup of G, the possibility of oxidation to a higher dimensional theory can immediately be deduced from the topology of H. Second, by comparing the actual symmetry groups appearing in maximal supergravities with the subgroups of SL(32,R) and Spin(32), we argue that these groups cannot serve as a local symmetry group for M-theory in a formulation of de Wit-Nicolai type.Comment: 18 pages, LaTeX, 1 figure, 2 table

A GTPase-induced switch in phospholipid affinity of collybistin contributes to synaptic gephyrin clustering

Synaptic transmission between neurons relies on the exact spatial organization of postsynaptic transmitter receptors, which are recruited and positioned by dedicated scaffolding and regulatory proteins. At GABAergic synapses, the regulatory protein collybistin (Cb, also known as ARHGEF9) interacts with small GTPases, cell adhesion proteins and phosphoinositides to recruit the scaffolding protein gephyrin and GABAA receptors to nascent synapses. We dissected the interaction of Cb with the small Rho-like GTPase TC10 (also known as RhoQ) and phospholipids. Our data define a protein– lipid interaction network that controls the clustering of gephyrin at synapses. Within this network, TC10 and monophosphorylated phosphoinositides, particulary phosphatidylinositol 3-phosphate (PI3P), provide a coincidence detection platform that allows the accumulation and activation of Cb in endomembranes. Upon activation, TC10 induces a phospholipid affinity switch in Cb, which allows Cb to specifically interact with phosphoinositide species present at the plasma membrane. We propose that this GTPase- based regulatory switch mechanism represents an important step in the process of tethering of Cb-dependent scaffolds and receptors at nascent postsynapses