Sensitivity of Lake Sturgeon population dynamics and genetics to demographic parameters [Powerpoint Slide]

Lake sturgeon Acipenser fulvescens restoration is a priority throughout the Great Lakes basin, where sturgeon have been reduced to less than 1% of historic levels due to habitat degradation, overharvest, and fragmentation of spawning populations. The population parameters most important to long-term lake sturgeon persistence are unknown

Well communities

Well Communities provides a framework for communities and local organisations (public, private and third sector) to work together to improve health and wellbeing, build resilience and reduce inequalities. Key concepts in engaging communities for social change and health improvement are integral to the Well Communities approach. These include whole systems, holistic and assets-based working, community engagement and community led action, community development and capacity building, co-production, positive psychology and empowerment. Through work over nine years with 33 of the most disadvantaged neighbourhoods in London, these concepts have been translated into a practical framework for actio

Micro-fabrication of Carbon Structures by Pattern Miniaturization in Resorcinol-Formaldehyde Gel

A simple and novel method to fabricate and miniaturize surface and sub-surface micro-structures and micro-patterns in glassy carbon is proposed and demonstrated. An aqueous resorcinol-formaldehyde (RF) sol is employed for micro-molding of the master-pattern to be replicated, followed by controlled drying and pyrolysis of the gel to reproduce an isotropically shrunk replica in carbon. The miniaturized version of the master-pattern thus replicated in carbon is about one order of magnitude smaller than original master by repeating three times the above cycle of molding and drying. The micro-fabrication method proposed will greatly enhance the toolbox for a facile fabrication of a variety of Carbon-MEMS and C-microfluidic devices.Comment: 16 pages, 5 figure

Finding character strengths through loss: an extension of Peterson and Seligman (2003)

People can experience positive changes even in the midst of adversity and loss. We investigated character strengths following three recent shooting tragedies. Using an Internet database of respondents to the Values in Action Inventory of Strengths (VIA-IS), we compared responses from three groups of participants (N = 31,429) within close proximity of each event: those who completed it eight months prior to the event, and one month and two months after. Results suggested that for one of the events, participants who completed the VIA-IS after the event showed slightly different levels of self-reported character strengths compared to participants who completed the VIA-IS before the event, with some mean levels higher and others lower. The observed differences in character strengths were inconsistent across follow-up periods, and effect sizes were small (d values from –0.13 to 0.15). These findings raise questions about whether and how tragedies might catalyze differences in character strengths

Sigma-phase in Fe-Cr and Fe-V alloy systems and its physical properties

A review is presented on physical properties of the sigma-phase in Fe-Cr and Fe-V alloy systems as revealed both with experimental -- mostly with the Mossbauer spectroscopy -- and theoretical methods. In particular, the following questions relevant to the issue have been addressed: identification of sigma and determination of its structural properties, kinetics of alpha-to-sigma and sigma-to-alpha phase transformations, Debye temperature and Fe-partial phonon density of states, Curie temperature and magnetization, hyperfine fields, isomer shifts and electric field gradients.Comment: 26 pages, 23 figures and 83 reference

Political Settlement in Somaliland: a gendered perspective

Research suggests that inclusive political settlements tend to be more stable. For Somaliland in the northern Horn of Africa, stability is underpinned by a patriarchal clan-based system that is non-gender-inclusive. The question therefore arises as to how the transition to greater inclusivity might be achieved without destabilising Somaliland’s political settlement in the process. The most recent 2012 Gender Inequality Index for Somalia rates the whole of the old Somali Republic at 0.776 (1 indicating maximum gender inequality), the fourth-lowest position in the index (UNDP Gender Unit, 2012). In practice, this means that the Somali territories are characterised by high levels of maternal mortality, gender-based violence, illiteracy, child marriage, rape, female genital mutilation and inadequate health services for women and girls. While this data does not relate to Somaliland alone, it provides a likely indication of the severity of the imbalance between women and men in the country. The data that is available for Somaliland shows similar gender disparities. Girls are less likely to be enrolled in primary school, for example, with 95,578 recorded in Somaliland in 2012/13 against an enrolment of 119,453 for boys. That disparity increases significantly at secondary level, with 12,306 female enrolments in the same year against 26,932 for males (MoLSA, 2014). Despite the pains of transition, there is good reason to consider a more inclusive political settlement as a means of reinvigorating the Somaliland polity. Our research and other evidence in the secondary literature show that people in Somaliland are becoming increasingly disillusioned with the ‘politicisation’ of clan and the rise of ‘clannism’. These developments in the political settlement are themselves potentially destabilising, but this time of change offers room for gender-focused activism that uses greater inclusivity for women and men (as well as minority groups) to help promote peaceful transition in Somaliland. In this report, we argue not only that the Somaliland political settlement is currently relatively stable but non-inclusive in gender terms, but that there are compelling reasons on both normative and instrumental grounds to urgently improve this situation. We present the results of a 21-month research project, including new primary data about attitudes towards improving women’s political participation and reducing gender-based violence. We conclude the report with a number of suggested initiatives, the contours of which are worth emphasising from the start. Firstly, it is important that international involvement is not seen to dominate gender initiatives to the degree that these interventions add to the growing perception that ‘women’s issues’ are a concern of liberal foreigners and are therefore ‘un-Somali’. Secondly, it is important that donor programmes seeking to address the gender-inclusivity of Somaliland’s political settlement take a long-term view, and are grounded in principles supported within Islamic ethical structures. The Somaliland government and political parties also have a significant role to play in opening spaces for both men and women to participate actively in political activities at all levels. Thirdly, therefore, we recommend a return to closed lists in elections, and a focus on finding ways to deliver on the constitutional guarantee of equal rights for all citizens. While it has supported Somaliland’s peace effectively in many ways, clan-based justice is manifestly unjust in many cases of sexual violence. Fourthly, we therefore suggest that it is important that mechanisms be found to draw customary elders into a legal system that provides more effectively for the victims in such cases. Somaliland’s success in establishing a viable political settlement in the face of considerable odds is impressive, but the transition from customary structures to those of representative nation-state politics exposes gender imbalances that could threaten to undermine that success. The research outlined in this report supports efforts to engender an inclusive and robust political settlement for the future

Impact Of The COVID-19 Pandemic On Online Obsessive-Compulsive Disorder Support Community Members: Survey Study

Background: People with obsessive-compulsive disorder (OCD) have faced unique challenges during the COVID-19 pandemic. Research from the first two months of the pandemic suggests that a small proportion of people with OCD experienced worsening in their OCD symptoms since the pandemic began, whereas the rest experienced either no change or an improvement in their symptoms. However, as society-level factors relating to the pandemic have evolved, the effects of the pandemic on people with OCD have likely changed as well, in complex and population-specific ways. Therefore, this study contributes to a growing body of knowledge on the impact of the COVID-19 pandemic on people and demonstrates how differences across studies might emerge when studying specific populations at specific timepoints. Objective: This study aimed to assess how members of online OCD support communities felt the COVID-19 pandemic had affected their OCD symptoms, around 3 months after the pandemic began. Methods: We recruited participants from online OCD support communities for our brief survey. Participants indicated how much they felt their OCD symptoms had changed since the pandemic began and how much they felt that having OCD was making it harder to deal with the pandemic. Results: We collected survey data from June through August 2020 and received a total of 196 responses, some of which were partial responses. Among the nonmissing data, 65.9% (108/164) of the participants were from the United States and 90.5% (152/168) had been subjected to a stay-at-home order. In all, 92.9% (182/196) of the participants said they experienced worsening of their OCD symptoms since the pandemic began, although the extent to which their symptoms worsened differed across dimensions of OCD; notably, symmetry and completeness symptoms were less likely to have worsened than others. Moreover, 95.5% (171/179) of the participants felt that having OCD made it difficult to deal with the pandemic. Conclusions: Our study of online OCD support community members found a much higher rate of OCD symptom worsening than did other studies on people with OCD conducted during the current COVID-19 pandemic. Factors such as quarantine length, location, overlapping society-level challenges, and differing measurement and sampling choices may help to explain this difference across studies

Phase II trial of dexverapamil and epirubicin in patients with non-responsive metastatic breast cancer.

Agents capable of reversing P-glycoprotein-associated multidrug resistance have usually failed to enhance chemotherapy activity in patients with solid tumours. Based on its toxicity profile and experimental potency, dexverapamil, the R-enantiomer of verapamil, is considered to be promising for clinical use as a chemosensitizer. The purpose of this early phase II trial was to evaluate the effects of dexverapamil on epirubicin toxicity, activity and pharmacokinetics in patients with metastatic breast cancer. A two-stage design was applied. Patients first received epirubicin alone at 120 mg m(-2) i.v. over 15 min, repeated every 21 days. Patients with refractory disease continued to receive epirubicin at the same dose and schedule but supplemented with oral dexverapamil 300 mg every 6 h x 13 doses. The Gehan design was applied to the dexverapamil/epirubicin cohort of patients. Thirty-nine patients were entered on study, 25 proceeded to receive epirubicin plus dexverapamil. Dexverapamil did not increase epirubicin toxicity. The dose intensity of epirubicin was similar when used alone or with dexverapamil. In nine intrapatient comparisons, the area under the plasma concentration-time curve (AUC) of epirubicin was significantly reduced by dexverapamil (mean 2968 vs 1901 microg ml[-1] h[-1], P= 0.02). The mean trough plasma levels of dexverapamil and its major metabolite nor-dexverapamil were 1.2 and 1.5 microM respectively. The addition of dexverapamil to epirubicin induced partial responses in 4 of 23 patients evaluable for tumour response (17%, CI 5-39%, s.e.P 0.079). The remissions lasted 3, 8, 11 and 11+ months. These data suggest that the concept of enhancing chemotherapy activity by adding chemosensitizers may function not only in haematological malignancies but also in selected solid tumours. An increase in the AUC and toxicity of cytotoxic agents does not seem to be a prerequisite for chemosensitizers to enhance anti-tumour activity

Selective ROCK2 inhibition in focal cerebral ischemia

Objective: Rho-associated kinase (ROCK) is a key regulator of numerous processes in multiple cell types relevant in stroke pathophysiology. ROCK inhibitors have improved outcome in experimental models of acute ischemic or hemorrhagic stroke. However, the relevant ROCK isoform (ROCK1 or ROCK2) in acute stroke is not known. Methods: We characterized the pharmacodynamic and pharmacokinetic profile, and tested the efficacy and safety of a novel selective ROCK2 inhibitor KD025 (formerly SLx-2119) in focal cerebral ischemia models in mice. Results: KD025 dose-dependently reduced infarct volume after transient middle cerebral artery occlusion. The therapeutic window was at least 3 h from stroke onset, and the efficacy was sustained for at least 4 weeks. KD025 was at least as efficacious in aged, diabetic or female mice, as in normal adult males. Concurrent treatment with atorvastatin was safe, but not additive or synergistic. KD025 was also safe in a permanent ischemia model, albeit with diminished efficacy. As one mechanism of protection, KD025 improved cortical perfusion in a distal middle cerebral artery occlusion model, implicating enhanced collateral flow. Unlike isoform-nonselective ROCK inhibitors, KD025 did not cause significant hypotension, a dose-limiting side effect in acute ischemic stroke. Interpretation Altogether, these data show that KD025 is efficacious and safe in acute focal cerebral ischemia in mice, implicating ROCK2 as the relevant isoform in acute ischemic stroke. Data suggest that selective ROCK2 inhibition has a favorable safety profile to facilitate clinical translation