Defocusing gravitational microlensing

We introduce the notion of defocusing gravitational lens considering a MACHO located behind a light source with respect to an observer. The consequence of defocusing effect is a temporal variability of star luminosity which produces a gap instead of a peak as tell--tale signature in the light curve. General theory of (de)focusing rays (geodesics) in a gravitational field is presented. Furthermore, we give estimations of the mass of the lens and the optical depth connected to such a phenomenon.Comment: 19 pages, latex, submitted to Physica Script

Continuous image distortion by astrophysical thick lenses

Image distortion due to weak gravitational lensing is examined using a non-perturbative method of integrating the geodesic deviation and optical scalar equations along the null geodesics connecting the observer to a distant source. The method we develop continuously changes the shape of the pencil of rays from the source to the observer with no reference to lens planes in astrophysically relevant scenarios. We compare the projected area and the ratio of semi-major to semi-minor axes of the observed elliptical image shape for circular sources from the continuous, thick-lens method with the commonly assumed thin-lens approximation. We find that for truncated singular isothermal sphere and NFW models of realistic galaxy clusters, the commonly used thin-lens approximation is accurate to better than 1 part in 10^4 in predicting the image area and axes ratios. For asymmetric thick lenses consisting of two massive clusters separated along the line of sight in redshift up to \Delta z = 0.2, we find that modeling the image distortion as two clusters in a single lens plane does not produce relative errors in image area or axes ratio more than 0.5%Comment: accepted to GR

The gravitational interaction of light: from weak to strong fields

An explanation is proposed for the fact that pp-waves superpose linearly when they propagate parallely, while they interact nonlinearly, scatter and form singularities or Cauchy horizons if they are antiparallel. Parallel pp-waves do interact, but a generalized gravitoelectric force is exactly cancelled by a gravitomagnetic force. In an analogy, the interaction of light beams in linearized general relativity is also revisited and clarified, a new result is obtained for photon to photon attraction, and a conjecture is proved. Given equal energy density in the beams, the light-to-light attraction is twice the matter-to-light attraction and four times the matter-to-matter attraction.Comment: 17 pages, LaTeX, no figures. To appear in General Relativity and Gravitatio

Might some gamma ray bursts be an observable signature of natural wormholes?

The extragalactic microlensing scenario for natural wormholes is examined. It is shown that the main features of wormhole lensing events upon the light of distant Active Galactic Nuclei (AGNs) are similar to some types of already observed Gamma Ray Bursts (GRBs). Using recent satellite data on GRBs, an upper limit to the negative mass density -- ${\cal O} (10^{-36})$ g cm$^{-3}$ -- under the form of wormhole-like objects is presented.Comment: extended version, additions on GRB physics, background sources and cosmological consequences. Two ps figures. Accpeted for publication in Phys. Rev.

Gravitational bending of light by planetary multipoles and its measurement with microarcsecond astronomical interferometers

General relativistic deflection of light by mass, dipole, and quadrupole moments of gravitational field of a moving massive planet in the Solar system is derived. All terms of order 1 microarcsecond are taken into account, parametrized, and classified in accordance with their physical origin. We calculate the instantaneous patterns of the light-ray deflections caused by the monopole, the dipole and the quadrupole moments, and derive equations describing apparent motion of the deflected position of the star in the sky plane as the impact parameter of the light ray with respect to the planet changes due to its orbital motion. The present paper gives the physical interpretation of the observed light-ray deflections and discusses the observational capabilities of the near-future optical (SIM) and radio (SKA) interferometers for detecting the Doppler modulation of the radial deflection, and the dipolar and quadrupolar light-ray bendings by the Jupiter and the Saturn.Comment: 33 pages, 10 figures, accepted to Phys. Rev.

Cosmological waveguides for gravitational waves

We study the linearized equations describing the propagation of gravitational waves through dust. In the leading order of the WKB approximation, dust behaves as a non-dispersive, non-dissipative medium. Taking advantage of these features, we explore the possibility that a gravitational wave from a distant source gets trapped by the gravitational field of a long filament of galaxies of the kind seen in the large scale structure of the Universe. Such a waveguiding effect may lead to a huge magnification of the radiation from distant sources, thus lowering the sensitivity required for a successful detection of gravitational waves by detectors like VIRGO, LIGO and LISA.Comment: 19 pages, compressed Latex fil

Classical tests for Weyl gravity: deflection of light and time delay

Weyl gravity has been advanced in the recent past as an alternative to General Relativity (GR). The theory has had some success in fitting galactic rotation curves without the need for copious amounts of dark matter. To check the viability of Weyl gravity, we propose two additional classical tests of the theory: the deflection of light and time delay in the exterior of a static spherically symmetric source. The result for the deflection of light is remarkably simple: besides the usual positive (attractive) Einstein deflection of $4GM/r_{0}$ we obtain an extra deflection term of $-\gamma r_{0}$ where $\gamma$ is a constant and $r_0$ is the radius of closest approach. With a negative $\gamma$, the extra term can increase the deflection on large distance scales (galactic or greater) and therefore imitate the effect of dark matter. Notably, the negative sign required for $\gamma$ is opposite to the sign of $\gamma$ used to fit galactic rotation curves. The experimental constraints show explicitly that the magnitude of $\gamma$ is of the order of the inverse Hubble length something already noted by Mannheim and Kazanas as an interesting numerical coincidence in the fitting of galactic rotation curves.Comment: 17 pages, one figure, version to be published in Phys. Rev.

Acute kidney disease and renal recovery : consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup

Consensus definitions have been reached for both acute kidney injury (AKI) and chronic kidney disease (CKD) and these definitions are now routinely used in research and clinical practice. The KDIGO guideline defines AKI as an abrupt decrease in kidney function occurring over 7 days or less, whereas CKD is defined by the persistence of kidney disease for a period of > 90 days. AKI and CKD are increasingly recognized as related entities and in some instances probably represent a continuum of the disease process. For patients in whom pathophysiologic processes are ongoing, the term acute kidney disease (AKD) has been proposed to define the course of disease after AKI; however, definitions of AKD and strategies for the management of patients with AKD are not currently available. In this consensus statement, the Acute Disease Quality Initiative (ADQI) proposes definitions, staging criteria for AKD, and strategies for the management of affected patients. We also make recommendations for areas of future research, which aim to improve understanding of the underlying processes and improve outcomes for patients with AKD

Association of Methylentetraydrofolate Reductase (MTHFR) 677 C > T gene polymorphism and homocysteine levels in psoriasis vulgaris patients from Malaysia: a case-control study

<p>Abstract</p> <p>Background</p> <p>The methylenetetrahydrofolate reductase (MTHFR) enzyme catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate and methyl donors. The methyl donors are required for the conversion of homocysteine to methionine. Mutation of MTHFR 677 C > T disrupts its thermostability therefore leads to defective enzyme activities and dysregulation of homocysteine levels.</p> <p>Methods</p> <p>This case-control study (n = 367) was conducted to investigate the correlation of the MTHFR gene polymorphism [NM_005957] and psoriasis vulgaris amongst the Malaysian population. Overnight fasting blood samples were collected from a subgroup of consented psoriasis vulgaris patients and matched controls (n = 84) for the quantification of homocysteine, vitamin B₁₂and folic acid levels.</p> <p>Results</p> <p>There was no significant increase of the MTHFR 677 C > T mutation in patients with psoriasis vulgaris compared with controls (<it>χ</it>²= 0.733, p = 0.392). No significant association between homocysteine levels and MTHFR gene polymorphism in cases and controls were observed (F = 0.91, df = 3, 80, p = 0.44). However, homocysteine levels in cases were negatively correlated with vitamin B₁₂(r = -0.173) and folic acid (r = -0.345) levels. Vitamin B₁₂and folic acid levels in cases were also negatively correlated (r = -0.164).</p> <p>Conclusions</p> <p>Our results indicate that there was no significant association between the MTHFR gene polymorphism and psoriasis vulgaris in the Malaysian population. There was no significant increase of the plasma homocysteine level in the psoriasis patients compared to the controls.</p

Inhibition of TIR Domain Signaling by TcpC: MyD88-Dependent and Independent Effects on Escherichia coli Virulence

Toll-like receptor signaling requires functional Toll/interleukin-1 (IL-1) receptor (TIR) domains to activate innate immunity. By producing TIR homologous proteins, microbes inhibit host response induction and improve their own survival. The TIR homologous protein TcpC was recently identified as a virulence factor in uropathogenic Escherichia coli (E. coli), suppressing innate immunity by binding to MyD88. This study examined how the host MyD88 genotype modifies the in vivo effects of TcpC and whether additional, TIR-domain containing proteins might be targeted by TcpC. In wild type mice (wt), TcpC enhanced bacterial virulence, increased acute mortality, bacterial persistence and tissue damage after infection with E. coli CFT073 (TcpC+), compared to a ΔTcpC deletion mutant. These effects were attenuated in Myd88−/− and Tlr4−/− mice. Transcriptomic analysis confirmed that TcpC inhibits MYD88 dependent gene expression in CFT073 infected human uroepithelial cells but in addition the inhibitory effect included targets in the TRIF and IL-6/IL-1 signaling pathways, where MYD88 dependent and independent signaling may converge. The effects of TcpC on bacterial persistence were attenuated in Trif −/− or Il-1β −/− mice and innate immune responses to ΔTcpC were increased, confirming that Trif and Il-1β dependent targets might be involved in vivo, in addition to Myd88. Furthermore, soluble TcpC inhibited Myd88 and Trif dependent TLR signaling in murine macrophages. Our results suggest that TcpC may promote UTI-associated pathology broadly, through inhibition of TIR domain signaling and downstream pathways. Dysregulation of the host response by microbial TcpC thus appears to impair the protective effects of innate immunity, while promoting inflammation and tissue damage