Phytochemical analysis, antioxidant and anti-inflammatory activity of leaves and bark of Ceropegia rollae Hemadri

The purpose of the present study is to evaluate in vitro antioxidant activity and anti-inflammatory activity of methanolic extract of the leaves and the bark of the plant Ceropegia rollae Hemadri. The antioxidant activity of the both leaves and bark extract was studied using FRAP and DPPH method. The in vitro anti-inflammatory activity and phytochemical characterization were carried using known protocols. The various phytochemical components such as total phenolics and flavonoids were determined. The plant Ceropegia rollae also contains tannis and ascorbic acid. This is related to the antioxidant activity of the plant Ceropegia rollae extract. The leaves shows good antioxidant and anti-inflammatory activity as compared to the bark. These can be used as natural antioxidant and anti-inflammatory agents

Green synthesis of the plant assisted nanoparticles from Euphorbia neriifolia L. and its application in the degradation of dyes from industrial waste

In the world industries are growing very rapidly resulting in fast development. Various industries are coming up such as that of dyes, paints, pharmaceuticals etc. Dyes are used in various industries and release pollutants in the environment. It is necessary to remove such pollutants from the environment. Euphorbia neriifolia L. grow as the weed in the forests of the konkan region in waste land area. This weed is a typical latex bearing plant. This latex can be converted into the powder under sun drying process. This powder can be used for the preparation of Fe nanoparticles. The plant assisted synthesized nanoparticles have good particle size, morphology and band gap. These nanoparticles used for the degradation of the dye like Methylene Blue and Methylene Red from the industrial waste. It gives very good results. We can develop new catalyst for the degradation of the dyes from the industrial waste. It act as good catalyst by the simple non form of the catalyst. This catalyst is derived from the plant Euphorbia neriifolia L. latex

Role of protein tyrosine kinase inhibitors in cancer therapeutics

273-280Protein tyrosine kinases (PTKs) are critical in regulating cell growth and differentiation and are deeply involved in several cancers. PTK-inhibitors are mainly ATP-site directed and are finding use in the treatment of several cancers, and more than 30 such agents are now in phase I-III clinical trials. The present review focuses mainly on the development of PTK inhibitors in clinical trials, with special emphasis on imatinib mesylate, a rationally designed, potent oral anticancer agent and selective inhibitor for Abl tyrosine kinase, including Bcr-Abl, C-kit and platelet-derived growth factor-receptor tyrosine kinases, which has been implicated in several malignancies, including chronic myeloid leukemia and gastrointestinal stromal tumour. </span

Case Report - Cutaneous neonatal lupus erythematosus with unusual features

A three month-old boy was brought by his mother with complaints of multiple reddish lesions on his trunk and face since birth. The patient had erythematous annular plaques with scaling on his extremities, palms and soles with periorbital erythema and edema giving the characteristic "eye mask" or "owl′s eye" appearance. His mother did not have history of any illness. Hemogram, liver and renal function tests were within normal limits. A skin biopsy was suggestive of subacute cutaneous lupus erythematosus. Immunological work-up was positive for antinuclear antibodies (ANA) (1:40) with anti-Ro titers of 3.4 and 3.47 (>1.1 = clinically significant titre) in the mother and child respectively, although negative for anti-La antibodies. The child′s electrocardiogram and 2D echocardiography were normal. We are presenting a case of anti-Ro-positive cutaneous lupus erythematosus with an uncommon skin manifestation