Interventions to reduce dependency in personal activities of daily living in community-dwelling adults who use homecare services: protocol for a systematic review

Background There is a growing demand for services whereby individuals receive assistance from care workers for personal care within the home. This has led to the development of re-ablement or restorative homecare services that provide time-limited input aimed at reducing dependency in personal activities of daily living, and preventing or delaying the need for further homecare support. However, little is currently known about how such interventions are configured, or how they may affect individuals’ ability to carry out personal care independently. Methods/Design We will seek to identify studies that compare an intervention designed to reduce dependency in personal activities of daily living with routine input or usual care as the control. We will include randomised controlled trials, nonrandomised controlled trials, and controlled before and after studies. We will also include interrupted time series studies. We shall search electronic databases in addition to searching for ongoing and unpublished studies, and where appropriate will contact key authors. Two reviewers will independently screen articles for inclusion; will assess risk of bias using quality assessment tools; and will carry out data extraction using pre-prepared forms. Any disagreements, at any stage, will be resolved by discussion and the involvement of a third reviewer if needed. We will produce a narrative summary of the results. A meta-analysis will be conducted if sufficient data are available of appropriate quality and comparability. Discussion The findings from this review will inform future practice within homecare re-ablement services; will inform policy decisions about the structure, organisation and content of such services; and will identify areas where further research is warranted

Adoption, attachment and relationship concerns: a study of adult adoptees

Given ongoing controversy regarding the psychosocial adjustment of adoptees, this study examined the impact of adoptive status and family experiences on adult attachment security, and the role of attachment in predicting relationship outcomes. Adults who were adopted as infants (N = 144), and a comparison sample of non-adoptees (N = 131), completed measures of attachment security at recruitment and again six months later; other measures assessed parental bonding and adoptees’ reunion experiences (Time 1), and relationship variables (e.g., loneliness, relationship quality; Time 2). Insecurity was higher for adoptees and for those reporting negative childhood relationships with parents. For adoptees only, recent relationship difficulties also predicted insecurity. Attachment dimensions were more important than adoptive status in predicting relationship variables, and mediated the effects of adoptive status. The results support the utility of attachment theory in understanding adoptees’ relationship concerns

Annual Narratives & Statistical Reports from state offices and county agents

The agent's annual report proving complete summary of all the work performed during the year. This would include but not limited to systematic records of notes of tasks completed, brief observations of general conditions observed, as well as detailed information regarding certain localities

Annual Narratives & Statistical Reports from state offices and county agents

The agent's annual report proving complete summary of all the work performed during the year. This would include but not limited to systematic records of notes of tasks completed, brief observations of general conditions observed, as well as detailed information regarding certain localities

Annual Narratives & Statistical Reports from state offices and county agents

The agent's annual report proving complete summary of all the work performed during the year. This would include but not limited to systematic records of notes of tasks completed, brief observations of general conditions observed, as well as detailed information regarding certain localities

Transcriptional Inhibition of the F ₁ F ₀ -Type ATP Synthase Has Bactericidal Consequences on the Viability of Mycobacteria

Bedaquiline, an inhibitor of the mycobacterial ATP synthase, has revolutionized the treatment of Mycobacterium tuberculosis infection. Although a potent inhibitor, it is characterized by poorly understood delayed time-dependent bactericidal activity. Here, we demonstrate that in contrast to bedaquiline, the transcriptional inhibition of the ATP synthase in M. tuberculosis and Mycobacterium smegmatis has rapid bactericidal activity. These results validate the mycobacterial ATP synthase as a drug target with the potential for rapid bactericidal activity. </jats:p