78 research outputs found
Method to determine the optimal parameters of the Arecibo 46.8-MHz antenna system
The spherical reflector at the Arecibo Observatory (AO) offers great advantages for the design of simple and inexpensive high performance steerable antennas at VHF. Light and small feeds have the added benefit that they can be quickly installed in the Arecibo platform. It is important to evaluate the performance of any given feed including the effects of the spherical reflector. The optimization is emphasized of two parameters, namely, the distance below the focal point of the reflector and the beam width of a point feed. For the design of the feed at 46.8 MHz at the AO there were other requirements independent of MST (mesosphere stratosphere troposphere) work. The design of the primary array is discussed along with its performance with the AO spherical reflector
Quantitative estimates of relationships between geomagnetic activity and equatorial spread-F as determined by TID occurrence levels
Using a world-wide set of stations for 15 years, quantitative estimates of changes to equatorial spread-F (ESF) occurrence rates obtained from ionogram scalings, have been determined for a range of geomagnetic activity (GA) levels, as well as for four different levels of solar activity. Average occurrence rates were used as a reference. The percentage changes vary significantly depending on these subdivisions. For example for very high GA the inverse association is recorded by a change of -33% for R-z greater than or equal to 150, and -10% for R-z < 50. Using data for 9 years for the equatorial station, Huancayo, these measurements of ESF which indicate the presence of TIDs, have also been investigated by somewhat similar analyses. Additional parameters were used which involved the local times of GA, with the ESF being examined separately for occurrence pre-midnight (PM) and after-midnight (AM). Again the negative changes were most pronounced for high GA in R-z-max years (-21%). This result is for PM ESF for GA at a local time of 1700. There were increased ESF levels (+31%) for AM ESF in R-z-min years for high GA around 2300 LT. This additional knowledge of the influence of GA on ESF occurrence involving not only percentage changes, but these values for a range of parameter levels, may be useful if ever short-term forecasts are needed. There is some discussion on comparisons which can be made between ESF results obtained by coherent scatter from incoherent-scatter equipment and those obtained by ionosondes
Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology
Glycosylation is the most abundant and diverse posttranslational modification of proteins. While several types of glycosylation can be predicted by the protein sequence context, and substantial knowledge of these glycoproteomes is available, our knowledge of the GalNAc-type O-glycosylation is highly limited. This type of glycosylation is unique in being regulated by 20 polypeptide GalNAc-transferases attaching the initiating GalNAc monosaccharides to Ser and Thr (and likely some Tyr) residues. We have developed a genetic engineering approach using human cell lines to simplify O-glycosylation (SimpleCells) that enables proteome-wide discovery of O-glycan sites using 'bottom-up' ETD-based mass spectrometric analysis. We implemented this on 12 human cell lines from different organs, and present a first map of the human O-glycoproteome with almost 3000 glycosites in over 600 O-glycoproteins as well as an improved NetOGlyc4.0 model for prediction of O-glycosylation. The finding of unique subsets of O-glycoproteins in each cell line provides evidence that the O-glycoproteome is differentially regulated and dynamic. The greatly expanded view of the O-glycoproteome should facilitate the exploration of how site-specific O-glycosylation regulates protein function
CMRegNet–An interspecies reference database for corynebacterial and mycobacterial regulatory networks
Population genomics of mycobacterium ieprae reveals a new genotype in Madagascar and the Comoros
Human settlement of Madagascar traces back to the beginning of the first millennium with the arrival of Austronesians from Southeast Asia, followed by migrations from Africa and the Middle East. Remains of these different cultural, genetic, and linguistic legacies are still present in Madagascar and other islands of the Indian Ocean. The close relationship between human migration and the introduction and spread of infectious diseases, a well-documented phenomenon, is particularly evident for the causative agent of leprosy, Mycobacterium leprae. In this study, we used whole-genome sequencing (WGS) and molecular dating to characterize the genetic background and retrace the origin of the M. leprae strains circulating in Madagascar (n = 30) and the Comoros (n = 3), two islands where leprosy is still considered a public health problem and monitored as part of a drug resistance surveillance program. Most M. leprae strains (97%) from Madagascar and Comoros belonged to a new genotype as part of branch 1, closely related to single nucleotide polymorphism (SNP) type 1D, named 1D-Malagasy. Other strains belonged to the genotype 1A (3%). We sequenced 39 strains from nine other countries, which, together with previously published genomes, amounted to 242 genomes that were used for molecular dating. Specific SNP markers for the new 1D-Malagasy genotype were used to screen samples from 11 countries and revealed this genotype to be restricted to Madagascar, with the sole exception being a strain from Malawi. The overall analysis thus ruled out a possible introduction of leprosy by the Austronesian settlers and suggests a later origin from East Africa, the Middle East, or South Asia.Immunogenetics and cellular immunology of bacterial infectious disease
The effects of level of automation on the out-of-the-loop unfamiliarity in a complex dynamic fault-management task during simulated spaceflight operations
Hatemoji: A test suite and adversarially-generated dataset for benchmarking and detecting emoji-based hate
Detecting online hate is a complex task, and
low-performing models have harmful consequences when used for sensitive applications
such as content moderation. Emoji-based hate
is a key emerging challenge for automated
detection. We present HATEMOJICHECK, a
test suite of 3,930 short-form statements that
allows us to evaluate performance on hateful language expressed with emoji. Using
the test suite, we expose weaknesses in existing hate detection models. To address these
weaknesses, we create the HATEMOJITRAIN
dataset using a human-and-model-in-the-loop
approach. Models trained on these 5,912 adversarial examples perform substantially better
at detecting emoji-based hate, while retaining
strong performance on text-only hate. Both
HATEMOJICHECK and HATEMOJITRAIN are
made publicly available
A theoretical study on accurate measurements of thoron with airflow-through scintillation cell method
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