Prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran

Asthma is the most common chronic disease among children, and its incidences are often imminent among elementary schoolchildren. This study aimed to examine the prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran. The prevalence rate was compared according to age group (aged 6–7 years vs. aged 13–14 years) and gender (male vs. female). In this cross-sectional study, 1706 Iranian schoolchildren aged 6–7 and 13–14 years in Golestan Province were enrolled. Participants completed questionnaires between February and July 2014. Asthma symptoms were assessed using the questionnaire of the International Study of Asthma and Allergies in Childhood protocol in Persian. The logistic regression model was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of the asthma symptoms for each of the gender and age groups. The prevalence rates of “current asthma” symptoms and “asthma ever” in all the children were estimated as 9.5% and 7.5%, respectively. The prevalence of asthma (“asthma ever” and “wheezing in the past 12 months”) in junior high schoolchildren (aged 13–14 years) is higher than that in elementary schoolchildren (aged 6–7 years) (P < 0.05). The prevalence of the severity of wheezing in girls is lower than that in boys (OR = 1.7, 95%CI = 1.06–2.96, P = 0.02). Asthma is still a major public health problem. This study shows that the prevalence of the asthma symptoms in boys is lower than that in girls in both age groups, and the severity of asthma in girls is higher than that in boys aged 13–14 years. © 2016 Higher Education Press and Springer-Verlag Berlin Heidelber

Biases in the Quasar Mass-Luminosity Plane

We find that the recently reported departure from the Eddington luminosity limit for the highest quasar black hole masses at a given redshift is an artifact due to biases in black hole mass measurements. This sub-Eddington boundary (with non-unity slope) in the quasar mass-luminosity plane was initially reported by Steinhardt & Elvis (2010a) using the FWHM-based black hole mass catalogue of Shen et al. (2008). However, the significance of the boundary is reduced when the FWHM-based mass-scaling relationship is recalibrated following Wang et al. (2009) and using the most updated reverberation mapping estimates of black hole masses. Furthermore, this boundary is not seen using mass estimates based on the line dispersion of the same quasars' MgII emission lines. Thus, the initial report of a sub-Eddington boundary with non-unity slope was due to biases in estimating masses using the FWHM of a fit of one or two Gaussians to quasar MgII emission lines. We provide evidence that using the line dispersion of the MgII line produces less biased black hole mass estimates.Comment: 11 pages, 10 figures, Accepted for publication in MNRA

Elastic Correlations in Nucleosomal DNA Structure

The structure of DNA in the nucleosome core particle is studied using an elastic model that incorporates anisotropy in the bending energetics and twist-bend coupling. Using the experimentally determined structure of nucleosomal DNA [T.J. Richmond and C.A. Davey, Nature {\bf 423}, 145 (2003)], it is shown that elastic correlations exist between twist, roll, tilt, and stretching of DNA, as well as the distance between phosphate groups. The twist-bend coupling term is shown to be able to capture these correlations to a large extent, and a fit to the experimental data yields a new estimate of G=25 nm for the value of the twist-bend coupling constant

Stochastic model for nucleosome sliding in the presence of DNA ligands

Heat-induced mobility of nucleosomes along DNA is an experimentally well-studied phenomenon. A recent experiment shows that the repositioning is modified in the presence of minor-groove binding DNA ligands. We present here a stochastic three-state model for the diffusion of a nucleosome along DNA in the presence of such ligands. It allows us to describe the dynamics and the steady state of such a motion analytically. The analytical results are in excellent agreement with numerical simulations of this stochastic process.With this model, we study the response of a nucleosome to an external force and how it is affected by the presence of ligands.Comment: 10 pages, 8 figures, submitted to Eur. Phys. J.

Supermassive Black Hole Mass Estimates Using Sloan Digital Sky Survey Quasar Spectra at 0.7 < z < 2

We present MgII-based black hole mass estimates for 27,602 quasars with rest-frame UV spectra available in the Sloan Digital Sky Survey Data Release Three. This estimation is possible due to the existence of an empirical correlation between the radius of the broad line region and the continuum luminosity at 3000 Angstroms. We regenerate this correlation by applying our measurement method to UV spectra of low-redshift quasars in the HST/IUE databases which have corresponding reverberation mapping estimates of the Hbeta broad line region's radius. Our mass estimation method uses the line dispersion rather than the full width at half maximum of the low-ionization MgII emission line. We measure MgII line dispersions for quasars whose spectra have been reconstructed using the most significant eigenspectra produced through Principal Component Analysis. We have tested the reliability of using reconstructed spectra in black hole mass estimation using a Monte Carlo simulation and by comparing the results from original and reconstructed Data Release Three spectra. We show that using reconstructed spectra not only makes bias-free mass estimation possible for quasars with low spectroscopic signal-to-noise ratio, but also reduces the intrinsic scatter of the distribution of the black hole masses to lower than 0.15 dex.Comment: 38 Pages, 12 figures, 3 Tables, 1 hyperlink to catalogue data. Accepted for publication in ApJ

Effect of Bending Anisotropy on the 3D Conformation of Short DNA Loops

The equilibrium three dimensional shape of relatively short loops of DNA is studied using an elastic model that takes into account anisotropy in bending rigidities. Using a reasonable estimate for the anisotropy, it is found that cyclized DNA with lengths that are not integer multiples of the pitch take on nontrivial shapes that involve bending out of planes and formation of kinks. The effect of sequence inhomogeneity on the shape of DNA is addressed, and shown to enhance the geometrical features. These findings could shed some light on the role of DNA conformation in protein--DNA interactions

Rapidly Spinning Black Holes in Quasars: An Open Question

Wang et al. (2006) estimated an average radiative efficiency of 30% -- 35% for quasars at moderate redshift. We find that their method is not independent of quasar lifetimes and thus that quasars do not necessarily have such high efficiencies. Nonetheless, it is possible to derive interrelated constraints on quasar lifetimes, Eddington ratios, and radiative efficiencies of supermassive black holes. We derive such constraints using a statistically complete sample of quasars with black hole mass estimates from broad Mg II, made both with and without the radiation pressure correction of Marconi et al. (2008). We conclude that for quasars with L/LEdd > 0.02, lifetimes can range from 140 to 750 Myr for Schwarzschild black holes. Coupled with observed black hole masses, quasar lifetimes of < 140 Myr would imply that radiatively inefficient accretion or BH mergers must be important in the accretion history of quasars. Given reasonable assumptions about the quasar population, if the average quasar lifetime is < 1 Gyr, and if radiatively inefficient accretion is unimportant, then not many BHs with Eddington ratio < 0.2 can be rapidly spinning.Comment: 14 pages, 3 figures, accepted by ApJ on Sep 200

The study of heavy metals Copper, Zinc, Iron and Manganese bioaccumulation in the eggs of rainbow trout (Oncorhynchus mykiss) during incubation period

The aims of the present study were to examine bioaccumulation of heavy metals copper, zinc, iron and manganese in rainbow trout eggs at different stages of incubation period and to compare the results with those of the EPA standards. The research was carried out at Firoozkooh Namroud Rainbow Trout Hatchery Center. For this purpose, two incubators with the same condition as experimental units were selected, one of them was the experimental incubator with approximately 60000 eggs and the other one had no eggs as the control. Sampling of eggs and water during incubation period was conducted weekly. The results showed significant differences (P<0.05) in the control incubator. This indicates that eggs have absorbed these elements from incubation water and then showed increasing trend for Zn and Fe elements concentration in dry weight egg extract during incubation stages but increasing trend in Mn and Cu elements went on until the third stage. The results indicate that threshold concentrations for Mn and Cu in egg cause egg resistance against more absorption of these elements. Also, the results showed that at all sampling stages, concentration of the studied elements was lower than EPA standards for animal textures